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Aproximación inicial al factor de crecimiento epidérmico en la infección por SARS-CoV-2
Resumen
Objetivos: Describir el comportamiento de los niveles séricos del EGF y evaluar su posible repercusión en el contexto de pacientes hospitalizados por COVID-19.
Métodos: Estudio exploratorio controlado, con muestreo por cuotas, en pacientes con COVID-19, ingresados en el Hospital "Saturnino Lora" y 23 sujetos aparentemente sanos, donantes activos del Banco de Sangre Renato "Guitar Rosell". Para las determinaciones de EGF se empleó el kit comercial UMELISA EGF del Centro de Inmunoensayo de Cuba. Se utilizaron medidas de resumen: frecuencia absoluta, porcentaje y media aritmética. La significación estadística de las diferencias observables entre grupos se exploró con la prueba de jicuadrado de Pearson, o la prueba t de Welch con α= 0,05.
Resultados: De 46 sujetos inscritos en el estudio, 50 % fueron positivos para el SARS-CoV-2 mediante RT-PCR. Entre los casos de COVID-19 y los controles, se observaron diferencias generales respecto al EGF (g= 1,4465; p= 0,0000*), con similar comportamiento en el sexo y la edad. En cuanto a la gravedad de la enfermedad, se observaron diferencias ligeras (g= 0,2152), tendencia que se acentuó en el sexo masculino (g= 1,1677) y las femenino (g= 0,7533), este último comparativamente menor.
Conclusiones: Determinar EGF sérico en pacientes infectados por SARS-CoV-2, pudiera tener un valor predictivo de la gravedad en pacientes con la COVID-19.
Palabras clave
Referencias
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