Aproximación inicial al factor de crecimiento epidérmico en la infección por SARS-CoV-2
Palabras clave:
COVID-19, factor de crecimiento epidérmico, inflamación, marcadores séricos.Resumen
Introducción: El receptor de factor de crecimiento epidérmico (EGF) juega un rol crítico en la inflamación pulmonar. Son escasos los datos referentes a los niveles séricos de su ligando principal.Objetivos: Describir el comportamiento de los niveles séricos del EGF y evaluar su posible repercusión en el contexto de pacientes hospitalizados por COVID-19.
Métodos: Estudio exploratorio controlado, con muestreo por cuotas, en pacientes con COVID-19, ingresados en el Hospital "Saturnino Lora" y 23 sujetos aparentemente sanos, donantes activos del Banco de Sangre Renato "Guitar Rosell". Para las determinaciones de EGF se empleó el kit comercial UMELISA EGF del Centro de Inmunoensayo de Cuba. Se utilizaron medidas de resumen: frecuencia absoluta, porcentaje y media aritmética. La significación estadística de las diferencias observables entre grupos se exploró con la prueba de jicuadrado de Pearson, o la prueba t de Welch con α= 0,05.
Resultados: De 46 sujetos inscritos en el estudio, 50 % fueron positivos para el SARS-CoV-2 mediante RT-PCR. Entre los casos de COVID-19 y los controles, se observaron diferencias generales respecto al EGF (g= 1,4465; p= 0,0000*), con similar comportamiento en el sexo y la edad. En cuanto a la gravedad de la enfermedad, se observaron diferencias ligeras (g= 0,2152), tendencia que se acentuó en el sexo masculino (g= 1,1677) y las femenino (g= 0,7533), este último comparativamente menor.
Conclusiones: Determinar EGF sérico en pacientes infectados por SARS-CoV-2, pudiera tener un valor predictivo de la gravedad en pacientes con la COVID-19.
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11. Saavedra D, Añé-Kourí AL, Gregorich EML, Mena J, Lorenzo-Luaces P, London HD, et al. Immune, inflammatory and prothrombotic parameters in COVID-19 patients treated with an anti EGFR antibody. [Internet]. Immunol Lett. 2022; 251-252:1-8. DOI: 10.1016/j.imlet.2022.09.005
12. Castells Martínez EM, del Valle R, González EC, Melchor A, Pérez PL, González I, et al. An enzyme immunoassay for determining epidermal growth factor (EGF) in human serum samples using an ultramicroanalytical system. [Internet]. J Immunoassay Immunochem. 2017; 38(2):190-201. DOI: 10.1080/15321819.2016.1236729
13. Crombet Ramos T, Santos Morales O, Dy GK, León Monzón K, Lage Dávila A. The Position of EGF Deprivation in the Management of Advanced Non-Small Cell Lung Cancer. Frontiers in Oncology. 2021; 11:639745. DOI: 10.3389/fonc.2021.639745
14. Ministry of Public Health. National Action Protocol for Covid-19. Version 1.7. Havana: Minsap; 2021.
15. Ministry of Public Health. Regulation D 03-21 Good Clinical Laboratory Practices. Havana: Center for State Control of Medicines, Medical Equipment and Devices (CECMED); 2021. [access: 22/04/2021]. Available at: https://www.cecmed.cu/sites/default/files/adjuntos/Regla-mentacion/ResRegBPLC%20firmada.pdf
16. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013; 310(20):2191-4. DOI: 10.1001/jama.2013.281053
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20. Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, et al. Integrative imaging reveals SARS-CoV-2-induced reshaping of subcellular morphologies. [Internet]. Cell Host Microbe. 2020; 28(6):853-66. DOI: 10.1016/j.chom.2020.11.003
21. Zanza C, Romenskaya T, Manetti AC, Franceschi F, La Russa R, Bertozzi G, et al. Cytokine storm in COVID-19: Immunopathogenesis and therapy. [Internet]. Medicine (Kaunas). 2022 [access: 12/04/2024]; 58(2):144. Available at: https://pubmed.ncbi.nlm.nih.gov/35208467
22. Monserrat J, Gómez-Lahoz A, Ortega M, Sanz J, Muñoz B, Arévalo-Serrano J, et al. Role of innate and adaptive cytokines in the survival of COVID-19 patients. [Internet]. Int J Mol Sci. 2022 [access: 12/04/2024]; 23(18):10344. Available at: https://pubmed.ncbi.nlm.nih.gov/36142255
23. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. [Internet]. Lancet. 2020 [access: 12/04/2024]; 395(10223):497-506. Available at: https://pubmed.ncbi.nlm.nih.gov/31986264
24. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. [Internet]. Lancet. 2020 [access: 12/04/2024]; 395(10229):1033-4. Available at: https://pubmed.ncbi.nlm.nih.gov/32192578
25. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. [Internet]. Nature. 2020 [access: 12/04/2024]; 579(7798):270-3. Available at: https://pubmed.ncbi.nlm.nih.gov/32015507
26. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. [Internet]. Cell. 2020 [access: 12/04/2024]; 181(2):271-280.e8. Available at: https://pubmed.ncbi.nlm.nih.gov/32142651
27. Karki R, Kanneganti TD. Innate immunity, cytokine storm, and inflammatory cell death in COVID-19. [Internet]. J Transl Med. 2022; 20(1): 542. DOI: 10.1186/s12967-022-03767-z
28. Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. [Internet]. Nat Commun. 2020; 11(1):1620. DOI: 10.1038/s41467-020-15562-9
29. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al. Cell entry mechanisms of SARS-CoV-2. [Internet]. Proc Natl Acad Sci US A. 2020 [access: 12/04/2024]; 117(21):11727-34. Available at: https://pubmed.ncbi.nlm.nih.gov/32376634
30. Hu B, Guo H, Zhou P, Shi ZL. Characteristics of SARS-CoV-2 and COVID-19. [Internet]. Nat Rev Microbiol. 2021; 19(3):141-54. DOI: 10.1038/s41579-020-00459-7
31. Qian YR, Guo YI, Wan HY, Fan L, Feng Y, Ni L, et al. Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. [Internet]. Oncol Rep. 2013 [access: 12/04/2024]; 29(6):2408-14. Available at: https://pubmed.ncbi.nlm.nih.gov/23545945
32. Zhong J, Li L, Wang Z, Bai H, Gai F, Duan J, et al. Potential resistance mechanisms revealed by targeted sequencing from lung adenocarcinoma patients with primary resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). [Internet]. J Thorac Oncol. 2017 [access: 12/04/2024]; 12(12):1766-78. Available at: https://pubmed.ncbi.nlm.nih.gov/28818608
33. Deben C, Le Compte M, Siozopoulou V, Lambrechts H, Hermans C, Lau HW, et al. Expression of SARS-CoV-2-related surface proteins in non-small-cell lung cancer patients and the influence of standard of care therapy. [Internet]. Cancers (Basel). 2022 [access: 12/04/2024]; 14(17):4074. Available at: https://pubmed.ncbi.nlm.nih.gov/36077610
34. Engler M, Albers D, Von Maltitz P, Groß R, Münch J, Cirstea IC. ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection. [Internet]. Life Sci Alliance. 2023 [access: 12/04/2024]; 6(9):e202201880. Available at: https://pubmed.ncbi.nlm.nih.gov/37402592
35. Yoo J, Perez CER, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E. TNF- α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts. [Internet]. Am J Physiol Gastrointest Liver Physiol. 2012 [access: 12/04/2024]; 302(8):G805-14. Available at: https://pubmed.ncbi.nlm.nih.gov/22301110
36. Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E. TNF- α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. [Internet]. BMC Gastroenterol. 2013 [access: 12/04/2024]; 13(1):90. DOI: 10.1186/1471-230X-13-90
37. Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, et al. EGFR signaling promotes TGF β -dependent renal fibrosis. [Internet]. J Am Soc Nephrol. 2012 [access: 12/04/2024]; 23(2):215-24. Available at: https://pubmed.ncbi.nlm.nih.gov/22095949
38. Zhuang S, Liu N. EGFR signaling in renal fibrosis. [Internet]. Kidney Int Suppl. 2014 [access: 12/04/2024]; 4(1):70-4. Available at: https://pubmed.ncbi.nlm.nih.gov/26312153
39. Single cell type - EGFR - The Human Protein Atlas. Proteinatlas.org. [access: 12/04/2024]. Available at: https://www.proteinatlas.org/ENSG00000146648-EGFR/single+cell+type
40. Single cell type - ACE2 - The Human Protein Atlas: single cell type. Proteinatlas.org. [access: 12/04/2024]. https://www.proteinatlas.org/ENSG00000130234-ACE2/single+cell+type
41. Kjær IM, Olsen DA, Alnor A, Brandslund I, Bechmann T, Madsen JS. EGFR and EGFR ligands in serum in healthy women; reference intervals and age dependency. [Internet]. Clin Chem Lab Med. 2019; 57(12):1948-55. DOI: 10.1515/ccLM-2019-0376
42. Meybosch S, De Monie A, Anné C, Bruyndonckx L, Jürgens A, De Winter BY, et al. Epidermal growth factor and its influencing variables in healthy children and adults. [Internet]. PLoS One. 2019 [access: 12/04/2024]; 14(1):e0211212. Available at: https://pubmed.ncbi.nlm.nih.gov/30677083
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02.10.2024
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1.
Pérez Hernández HJ. Aproximación inicial al factor de crecimiento epidérmico en la infección por SARS-CoV-2. Rev Cubana Med Milit [Internet]. 2 de octubre de 2024 [citado 2 de abril de 2025];53(4):e024060858. Disponible en: https://revmedmilitar.sld.cu/index.php/mil/article/view/60858
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