Caracterización clínica epidemiológica de pacientes operados de tumores raquimedulares
Abstract
Introducción: Los tumores raquimedulares son la mayor causa de morbilidad y mortalidad entre pacientes con afecciones oncológicas y representan aproximadamente del 10 al 15 % de todos los tumores del sistema nervioso central.
Objetivo: Identificar aspectos clínicos y epidemiológicos en pacientes operados de tumores raquimedulares.
Métodos: Se realizó un estudio observacional descriptivo, de serie de casos, en 31 pacientes de más de 19 años, operados de tumores intrarraquídeos, en el servicio de Neurocirugía del Hospital Provincial Docente "Saturnino Lora" de Santiago de Cuba, durante el período comprendido desde enero del 2008 a diciembre del 2013.
Resultados: En los casos estudiados (n= 31) la edad tuvo un recorrido entre 19 y 76 años, predominó el sexo femenino (54,8 %), las lesiones benignas (64,5 %), así como mayor localización dorsal y extradural en el eje espinal.
Conclusiones: Las principales características clínicas y epidemiológicas fueron: edad de presentación más frecuente en la sexta década de la vida, sintomatología con compromiso neurológico variable, dolor del raquis en todos los casos y predominio de lesiones benignas.
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References
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25. Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC. Decompression surgery for spinal metastases: a systematic review. Neurosurg Focus. 2016;41(2):1-35. Access: 03/03/2018. Available from: https://thejns.org/downloadpdf/journals/neurosurg-focus/41/2/article-pE2.pdf
26. He J, Xiao J, Peng X, Duan B, Li Y, Ai P. Dose escalation by image-guided intensity-modulated radiotherapy leads to an increase in pain relief for spinal metastases: a comparison study with a regimen of 30 Gy in 10 fractions. Oncotarget, 2017;8(68):112330-40. Access: 03/03/ 2018. Available from: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18979&path[]=60831
27. Sung WS, Sung MJ, Chan JH, Manion B, Song J, Dubey A. Intramedullary spinal cord metastases: a 20-year institutional experience with a comprehensive literature review. World Neurosurg. 2013;79:576-84.
28. Sun J, Wang Z, Li Z, Liu B. Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors. Clin Neurosci. 2009;16(5):666-71. Access: 03/03/2018. Available from: https://www.sciencedirect.com/science/article/pii/S0967586808004803?via%3Dihub
29. Guerrero-Suárez PD, Magdaleno-Estrella E, Guerrero-López P, Vargas-Figueroa AI, Martínez-Anda JJ. Intradural spinal tumors: 10 - years surgical experience in a single institution. Clin Neurol Neurosurg. 2018;169:98-102.
2. Karhade AV, Vasudeva VS, Dasenbrock HH, Lu Y, Gormley WB, Groff MW. Thirty-day readmission and reoperation after surgery for spinal tumors: a National Surgical Quality Improvement Program analysis. Neurosurg Focus. 2016;41(13):[aprox. 20 pant.]. Access: 03/03/2018. Available from: http://thejns.org/doi/full/10.3171/2016.5.FOCUS16168
3. Greenberg MS. Manual de Neurocirugía. 2da edición. Buenos Aires: Ediciones Journal; 2013.
4. Bansal S, Ailawadhi P, Suri A, Kale SS, Sarat Chandra P, Singh M. Ten years' experience in the management of spinal intramedullary tumors in a single institution. J Clin Neurosci. 2013;20(2):292-8. Access: 03/03/2018. Available from: https://www.jocn-journal.com/article/S0967-5868(12)00351-7/fulltext
5. Pendleton C, Rincon-Torroella J, Gokaslan ZL, Jallo GI, Quinones-Hinojosa A. Challenges in early operative approaches to intramedullary spinal cord tumors: Harvey Cushing's perspective. J Neurosurg Spine. 2015;23:412-8. Access: 3/03/2018. Available from: http://thejns.org/doi/full/10.3171/2014.12.SPINE13427
6. Ogden AT, Schwartz TH, McCormick PC. Spinal Cord Tumors in Adults. En: Winn HR, editor. Youmans Neurological Surgery. Philadelphia: Elsevier;2011. p. 3131-43.
7. Karsy M, Guan J, Sivakumar W, Neil JA, Schmidt MH, Mahan MA. The genetic basis of intradural spinal tumors and its impact on clinical treatment. Neurosurg Focus. 2015;39(13):[aprox. 31 pant.]. Access: 03/03/2018. Available from: http://thejns.org/doi/full/10.3171/2015.5.FOCUS15143
8. Ottenhausen M, Ntoulias G, Bodhinayake I, Rupert FH, Schreiber S, Förschler A. Intradural spinal tumors in adults-update on management and outcome. Neurosurg Rev, 2018;41(1):1-18. Access: 03/03/2018. Available from: https://doi.org/10.1007/s10143-018-0957-x
9. Hirano K, Imagama S, Sato K, Kato F, Kawa Y, Yoshihara H. Primary spinal cord tumors: review of 678 surgically treated patients in Japan. A multicenter study Eur Spine J. 2012;21(10):2019-26.
10. Hernández Solarte A, Losada Díaz A, Ortega Campos LG. Estudio de la incidencia de tumores raquimedulares tratados en el servicio de neurocirugía hospital San Juan de Dios y revisión del tema. Neuroeje. 1999;13(3): 102-8. Acceso: 03/03/2018. Disponible en: http://www.binasss.sa.cr/revistas/neuroeje/v13n3/art7.pdf
11. Da Roza P. Primary intraspinal tumours: their clinical presentation and diagnosis. An analysis of ninety-five cases. J Bone Joint Surg Am. 2009;46:8-15.
12. Matsumoto M, Tsuji T, Iwanami A, Watanabe K, Hosogane N, Ishii K. Total in bloc spondylectomy for spinal metastasis of differentiated thyroid cancers: a long-term follow-up. Spinal Disord Tech. 2013;26(4): 137-42. Access: 3/03/2018] Available from: https://insights.ovid.com/crossref?an=00024720-201306000-00013#
13. Kaloostian PE, Zadnik PL, Etame AB, Vrionis FD, Gokaslan ZL, Sciubba DM. Surgical management of primary and metastatic spinal tumors. Cancer Contr. 2014;21:133-9.
14. Mesfin A, Buchowski JM, Gokaslan ZL, Bird JE. Management of metastatic cervical spine tumors. J Am Acad Orthop Surg. 2015;23:38-46.
15. Schairer WW, Carrer A, Sing DC, Chou D, Mummaneni PV, Hu SS. Hospital readmission rates after surgical treatment of primary and metastatic tumors of the spine. Spine 2014;39(21):1801-8. Access: 03/03/2018. Available from: https://journals.lww.com/spinejournal/Fulltext/2014/10010/Hospital_Readmission_Rates_After_Surgical.17.aspx
16. Zwagerman NT, McDowell MM, Hamilton RL, Monaco III EA, MD, Flickinger JC, Gerszten PC. Histopathological examination of spine tumors after treatment with radiosurgery. Neurosurg Focus. 2016;41(2):1-4. Access: 03/03/2018. Available from: http://thejns.org/doi/full/10.3171/2016.5.FOCUS16119
17. Loya JJ, Jung H, Temmins C, Cho N, Singh H. Primary spinal germ cell tumors: a case analysis and review of treatment paradigms. Case Rep Med. 2013(2013):[aprox. 16 scr ]. Access: 03/03/2018. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838823/
18. Molina CA, Sciubba DM. Tumors of the Spine. En: Baaj AA, Mummaneni PV, Uribe JS, Vaccaro AR, Greenberg MS. Handbook of Spine Surgery. New York: Thieme Medical Publishers, Inc; 2012.
19. Alpízar-Aguirre A, Chávez C, Zarate B, Rosales LM, Baena L, Reyes A. Tumores intradurales extramedulares primarios tratados en el instituto nacional de rehabilitación. Cir Ciruj. 2009;77:107-10. Acceso: 03/03/2018. Disponible en: http://www.medigraphic.com/pdfs/circir/cc-2009/cc092e.pdf
20. Claus E, Abdel-Wahab M, Burger PC, Engelhard H. Defining future directions in spinal cord tumor research: J Neurosurg Spine. 2010;12(2):117-21. Access: 03/03/2018. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193276/pdf/nihms-278450.pdf
21. Tobin MK, Geraghty JR, Engelhard HH, Linninger AA, Mehta AI. Intramedullary spinal cord tumors: a review of current and future treatment strategies. Neurosurg Focus. 2015;39(10):[aprox. 25 scr.]. Access: 03/03/2018. Available from: http://thejns.org/doi/full/10.3171/2015.5.FOCUS15158
22. Mc Cormick P. Intradural extramedullary tumors. En: Quiñones-Hinojosa A. Operative Neurosurgical Techniques Indications, Methods, And Results. Philadelphia: Elsevier; 2012. p. 2126-2133.
23. Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014;16(Suppl 4):1-63.
24. Samuel N, Tetreault L, Santaguida C, Nater A, Moayeri N, Massicotte EM. Clinical and pathological outcomes after resection of intramedullary spinal cord tumors: a single-institution case series. Neurosurg Focus. 2016;41(2):1-8. Access: 03/03/2018. Available from: https://thejns.org/downloadpdf/journals/neurosurg-focus/41/2/article-pE8.pdf
25. Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC. Decompression surgery for spinal metastases: a systematic review. Neurosurg Focus. 2016;41(2):1-35. Access: 03/03/2018. Available from: https://thejns.org/downloadpdf/journals/neurosurg-focus/41/2/article-pE2.pdf
26. He J, Xiao J, Peng X, Duan B, Li Y, Ai P. Dose escalation by image-guided intensity-modulated radiotherapy leads to an increase in pain relief for spinal metastases: a comparison study with a regimen of 30 Gy in 10 fractions. Oncotarget, 2017;8(68):112330-40. Access: 03/03/ 2018. Available from: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18979&path[]=60831
27. Sung WS, Sung MJ, Chan JH, Manion B, Song J, Dubey A. Intramedullary spinal cord metastases: a 20-year institutional experience with a comprehensive literature review. World Neurosurg. 2013;79:576-84.
28. Sun J, Wang Z, Li Z, Liu B. Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors. Clin Neurosci. 2009;16(5):666-71. Access: 03/03/2018. Available from: https://www.sciencedirect.com/science/article/pii/S0967586808004803?via%3Dihub
29. Guerrero-Suárez PD, Magdaleno-Estrella E, Guerrero-López P, Vargas-Figueroa AI, Martínez-Anda JJ. Intradural spinal tumors: 10 - years surgical experience in a single institution. Clin Neurol Neurosurg. 2018;169:98-102.
Published
2019-01-07
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1.
Singuepire A, Figueredo Acosta H, Fonseca Sosa K. Caracterización clínica epidemiológica de pacientes operados de tumores raquimedulares. Rev Cubana Med Milit [Internet]. 2019 Jan. 7 [cited 2025 May 20];48(1):56-6. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/196
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