Primary thyroid lymphoma
Keywords:
lymphoma, thyroid gland, thyroiditis, thyroidectomy, ultrasonography.Abstract
Introduction: Primary thyroid lymphoma is a rare disease. Early diagnosis implies a precise clinical evaluation, imaging, cytological and immunological studies. Treatment modalities include chemotherapy, surgery, and radiation therapy.
Objective: To report the clinical case of a patient with primary thyroid lymphoma as a form of neoplastic presentation in the course of a multinodular goiter that required surgical treatment.
Clinical case: A 56-year-old patient presented with a giant neck tumor, accompanied by dyspnea, dysphagia, dysphonia, signs of vascular compression, and lymphadenopathy. Fine-needle aspiration cytology reported multinodular goiter. Due to the suspicion of malignancy, surgical treatment was decided, which consisted of a total thyroidectomy with lymphadenectomy. The histological result confirmed a primary thyroid lymphoma. She evolved favorably and continued follow-up by oncology.
Conclusions: In this case a patient with a rare disease is presented, however, deep knowledge of the essential aspects of early diagnosis and timely treatment, increase the survival rate.
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References
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2. Peixoto R, Correia J, Soares V, Koch P, Taveira A: Primary thyroid lymphoma: a case report and review of the literature. Ann Med Surg. 2017; 13:29-33. DOI:10.1016/j.amsu.2016.12.023
3. Herranz S, Castro M, Vicente D, Sastre M, Aguirre S. Linfomas primarios tiroideos. Experiencia en hospitales de Castilla-La Mancha. Rev Endocrinol Diabetes Nutr. 2018; 65(3):184-186. DOI:10.1016/j.endinu.2017.11.005
4. Causa R, Causa J, González Y. Bocio multinodular gigante. Revisión de la literatura a propósito de un caso. Rev Colomb Cir. 2020; 35:483-90. DOI:10.30944/20117582.469
5. Fang S, Gkiousias V, Hu L, Kapoor K. Tracheal invasion and cardiopulmonary compromise from primary thyroid lymphoma. Cureus. 2021; 13(11):19302. DOI:10.7759/cureus.19302
6. Vera E, Lazo C, Cedeño S, Bravo C. Actualización sobre el cáncer de tiroides. Rev Científica Mundo de la Investigación y el Conocimiento. 2018; 2(3): 16-42. DOI:10.26820/recimundo/2.(3).julio.2018.16-42
7. Ríos A, Febrero B, Parrilla P. Linfoma primario del tiroides. Endocrinol y Nutr. 2014; 61:497-499. DOI:10.1016/j.endonu.2014.04.007
8. Pavlidis E, Pavlidis T. A review of primary thyroid lymphoma: molecular factors, diagnosis and management. J Invest Surg. 2019; 32:137-142. DOI: 10.1080/08941939.2017.1383536
9. Cabecadas J, Martínez D, Andreasen S, Hjorth L, Molina R, Hall D, et al. Lymphomas of the head and neck region: an update. Virchows Arch. 2019; 474(6): 649–65. DOI:10.1007/s00428-019-02543-7
10. Saurith J, Pila R, Pila P, Rosales P. Bocio endotorácico asociado a tiroiditis de Hashimoto como causa de fiebre de origen desconocido, reporte de caso. Rev Colomb Endocrinol Diabet Metab. 2021; 5(3):49-52. DOI:10.53853/encr.5.3.436
11. Acar N, Acar T, Avci A, Haciyanli M. Approach to primary thyroid lymphoma: case series. Turk J Surg. 2019; 35(2):142-5. DOI:10.5578/turkjsurg.4132
12. Oueslati I, Chatti H, Yazidi M, Chaker F, Chihaoui M. A diffuse large B-cell thyroid lymphoma presented as a compressive goiter in a young woman with no evidence of Hashimoto thyroiditis. Clin Case Rep. 2021; 9(7):e04436. DOI:10.1002/ccr3.4436
13. Sharma A, Jasim S, Reading C, Ristow K, Villashoas J, Habermann T. Clinical presentation and diagnostic challenges of thyroid lymphoma: a cohort study. Thyroid. 2016; 26(8):1061-1067. DOI:10.1089/thy.2016.0095
14. Hu G, Zhu X. Ultrasonographic features of aggressive primary thyroid diffuse B-cell lymphoma: a report of two cases. Oncol Lett. 2016; 11:2487-90. DOI:10.3892/ol.2016.4255
15. Loccisano H, Montesinos MF, Montesinos M. Linfomas extranodales de cabeza y cuello. Rev Argent Cir. 2021; 113(1):24-31. DOI:10.25132/raac.v113.n1.1529.ei
16. Ahmed O, Salih Z. Dual malignancy in a thyroid; papillary thyroid carcinoma and small lymphocytic lymphoma; a report of a case with a cyto-histologic correlation. Diagn Cytopathol. 2017; 45(9):851-856. DOI:10.1002/dc.23748
17. Karvounis E, Kappas I, Angelousi A, Makris G, Kassi E. Mucosa-associated lymphoid tissue lymphoma of the thyroid gland: A systematic review the literature. Eur Thyroid J. 2020; 9:11–18. DOI:10.1159/000502204
18. Czopnik P, Aporowicz M, Niepokoj-Czopnik A, Wojtczak B, Domoslawski P, Bolanowski M. Primary thyroid lymphoma: a rare but challenging diagnosis. Rev Pol Arch Intern Med. 2017; 127(5). DOI:10.20452/pamw.4037
Published
2022-07-28
How to Cite
1.
Bejerano RJ. Primary thyroid lymphoma. Rev Cubana Med Milit [Internet]. 2022 Jul. 28 [cited 2025 May 14];51(4):e02201964. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/1964
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