Probiotics in the treatment of symptoms of irritable bowel syndrome
Keywords:
abdominal pain, irritable bowel syndrome, Lactobacillus, probiotics, symptomsAbstract
Introduction: Irritable bowel syndrome is a common digestive disorder in people under 50 years of age, characterized by abdominal pain, constipation and diarrhea.
Objective: To analyze the effect of probiotics on the clinical symptoms of irritable bowel syndrome in adult patients.
Methods: A scoping review was conducted using the database of the Virtual Library of the Universidad César Vallejo, including Scopus, PubMed, Proquest and EbscoHost, using probiotics, irritable bowel syndrome and type of study as search terms. Studies published between 2016 and June 2021 were selected; in any language, and included patients over 16 years of age with a diagnosis of IBS according to ROME III and ROME IV criteria, and included probiotic supplementation. Pregnant women and those with medication changes before or during the study were excluded. We found 4989 articles and selected 18 clinical trials.
Results: The most commonly used probiotics were Lactobacillus, Bifidobacterium and Bacillus coagulans, and 13 of 18 trials showed improvement in abdominal pain, diarrhea, constipation or bloating in irritable bowel syndrome. The duration of treatment ranged from 4 to 16 weeks, and the dose of probiotics, administered individually or in multi-strain combinations, was found to be in the order of 109 to 1010 CFU/day.
Conclusion: Probiotics improve the symptoms of irritable bowel syndrome in patients during their treatment.
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References
1. González M, De Ascencao M. Síndrome del Intestino Irritable. Aspectos Psicológicos [Internet]. Revista de la Facultad de Medicina. 2021 [acceso: 08/12/2021]; 28(2):139-45. Disponible en: http://ve.scielo.org/scielo.php?pid=S0798-04692005000200007&script=sci_arttext&tlng=en
2. Mariños H, Chafloque A. Asociación entre el Síndrome de Intestino Irritable y la ansiedad y depresión en pacientes atendidos en el Hospital Regional Docente de Trujillo [Internet]. Rev Med Trujillo. 2019; 14(4):181-88. DOI: 10.17268/rmt.2019.v14i04.05
3. Barberio B, Houghton LA, Yiannakou Y, Savarino EV, Black CJ, Ford AC. Symptom Stability in Rome IV vs Rome III Irritable Bowel Syndrome [Internet]. Am J Gastroenterol. 2021; 116(2):362-71. DOI: 10.14309/ajg.0000000000000946
4. Satish L, Pugalenthi L, Ahmad M, Reddy S, Barkhane Z, Elmadi J. Probiotics in Irritable Bowel Syndrome: A Review of Their Therapeutic Role [Internet]. Cureus. 2022; 14(4):1-10. DOI: 10.7759/cureus.24240
5. Marlicz W, Skonieczna-Zydecka K, Krynicka P, Loniewski I, Rydzewska G. Probiotics in irritable bowel syndrome - is the quest for the right strain over? Rapid review of existing guidelines and recommendations [Internet]. Prz Gastroenterol. 2021; 16(4):369-82. DOI: 10.5114/pg.2021.111766
6. Camilleri M. Irritable Bowel Syndrome: Straightening the road from the Rome criteria [Internet]. Neurogastroenterol Motil. 2020; 32(11):1-15. DOI: 10.1111/nmo.13957
7. Page MJ, Mckenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews [Internet]. BMJ. 2021; 372(71):1-8. DOI: 10.1136/bmj.n71
8. Mezzasalma V, Manfrini E, Ferri E, Sandionigi A, La Ferla B, Schiano I, et al. A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation [Internet]. Biomed Res Int. 2016; 2016(1):4740907. DOI: 10.1155/2016/4740907
9. Majeed M, Nagabhushanam K, Natarajan S, Sivakumar A, Ali F, Pande A, et al. Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: A double blind randomized placebo controlled pilot clinical study [Internet]. Nutr J. 2016; 15:21. DOI: 10.1186/s12937-016-0140-6
10. Šmid A, Strniša L, Bajc K, Vujic-Podlipec D, Bogovic Matijašic B, Rogelj I. Randomized clinical trial: The effect of fermented milk with the probiotic cultures Lactobacillus acidophilus La-5® and Bifidobacterium BB-12® and Beneo dietary fibres on health-related quality of life and the symptoms of irritable bowel syndrome in adult [Internet]. J Funct Foods. 2016; 24(Suppl. 3 Pt. 2):549-57. DOI: 10.1016/j.jff.2016.04.031
11. Hod K, Sperber AD, Ron Y, Boaz M, Dickman R, Berliner S, et al. A double-blind, placebo-controlled study to assess the effect of a probiotic mixture on symptoms and inflammatory markers in women with diarrhea-predominant IBS [Internet]. Neurogastroenterol Motil. 2017; 29(7):1-10. DOI: 10.1111/nmo.13037
12. Cremon C, Guglielmetti S, Gargari G, Taverniti V, Castellazzi AM, Valsecchi C, et al. Effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: A pilot randomized clinical trial [Internet]. United Eur Gastroenterol J. 2018; 6(4):604-13. DOI: 10.1177/2050640617736478
13. Ishaque SM, Khosruzzaman SM, Ahmed DS, Sah MP. A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome [Internet]. BMC Gastroenterol. 2018; 18(1):71. DOI: 10.1186/s12876-018-0788-9
14. Shin SP, Choi YM, Kim WH, Hong SP, Park JM, Kim J, et al. A double blind, placebo-controlled, randomized clinical trial that breast milk derived-Lactobacillus gasseri BNR17 mitigated diarrhea-dominant irritable bowel syndrome [Internet]. J Clin Biochem Nutr. 2018; 62(2):179-86. DOI: 10.3164/jcbn.17-73
15. Sun YY, Li M, Li YY, Li LX, Zhai WZ, Wang P, et al. The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial [Internet]. Sci Rep. 2018; 8(1):2964. DOI: 10.1038/s41598-018-21241-z
16. Lee SH, Cho DY, Lee SH, Han KS, Yang SW, Kim JH, et al. A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue [Internet]. Korean J Fam Med. 2019; 40(1):2-8. DOI: 10.4082/kjfm.17.0064
17. Madempudi RS, Ahire JJ, Neelamraju, J, Tripathi A, Nanal S. Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults [Internet]. Sci Rep. 2019; 9(1):12210. DOI: 10.1038/s41598-019-48554-x
18. Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial [Internet]. The Lancet Gastroenterology and Hepatology. 2020 [acceso: 05/03/2022]; 5(7):658- 66. Disponible en: https://bit.ly/47rfzYz
19. Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, De Angelis M, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients [Internet]. Eur J Clin Invest. 2020; 50(3):e13201. DOI: 10.1111/eci.13201
20. Kim J, Cho K, Kim JS, Jung HC, Kim B, Park MS, et al. Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial [Internet]. Food Sci Biotechnol. 2020; 29(6):837-44. DOI: 10.1007/s10068-019-00717-2
21. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial [Internet]. Nutrients. 2020; 12(2):363. DOI: 10.3390/nu12020363
22. Skrzydlo B, Prozorow B, Cichoz H, Majsiak E, Bierla JB, Kosikowski W, et al. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study [Internet]. Nutrients. 2020; 12(7):1999. DOI: 10.3390/nu12071999
23. Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome. A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant] [Internet]. Medicine. 2021; 100(3):e23641. DOI: 10.1097/MD.0000000000023641
24. Liu Y, Yu X, Yu L, Tian F, Zhao J, Zhang H, et al. Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Trial [Internet]. Engineering. 2021; 7(3):376- 85. DOI: 10.1016/j.eng.2020.06.026
25. Skrzydlo B, Prozorow B, Cichoz H, Majsiak E, Bierla JB, Kanarek E, et al. The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study [Internet]. Nutrients. 2021; 13(3):756. DOI: 10.3390/nu13030756
26. Chen M, Yuan L, Chao-Rong X, Xiao-Ying W, Si-Jia F, Xin-Yu X, et al. Probiotics for the management of irritable bowel syndrome: a systematic review and three-level meta-analysis [Internet]. Int J Surg. 2023; 109(11):3631-47. DOI: 10.1097/JS9.0000000000000658
27. Benjak Horvat I, Gobin I, Kresovic A, Hauser G. How can probiotic improve irritable bowel syndrome symptoms? [Internet]. World J Gastrointest Surg. 2021; 13(9):923-40. DOI: 10.4240/wjgs.v13.i9.923
28. Liang H, Luo Z, Miao Z, Shen X, Li M, Zhang Z, et al. Lactobacilli and bifidobacteria derived from infant intestines may activate macrophages and lead to different IL-10 secretion [Internet]. Biosci Biotechnol Biochem. 2020; 84(12):2558-68. DOI: 10.1080/09168451.2020.1811948
29. Cocetta V, Giacomini I, Tinazzi M, Berretta M, Quagliariello V, Maurea N, et al. Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins [Internet]. Minerva Pediatrics. 2023; 75(1):1-9. DOI: 10.23736/S2724-5276.23.07128-8
30. Konturek P, Konturek K, Brzozowski T, Wojcik D, Magierowski M, Targosz A, et al. Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic syngut on experimental colitis under stress conditions [Internet]. Journal of Physiology and Pharmacology. 2020; 71(3):329-42. DOI: 10.26402/jpp.2020.3.03
31. Jian-Rong S, Chen-Fan K, Xiang-Ke Q, Chao D, Yan-Ni L, Li-Qun J. Efficacy and safety of probiotics in irritable bowel syndrome. A systematic review and meta-analysis [Internet]. Saudi Journal of Gastroenterology. 2020; 26(2):66-77. DOI: 10.4103/sjg.SJG_384_19
32. Ceccherini C, Daniotti S, Bearzi C, Re I. Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis [Internet]. Nutrients. 2022; 14(13):2689. DOI: 10.3390/nu14132689
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