Diagnostic Accuracy of Insulin Resistance in Diabetes and Prediabetes
Keywords:
diabetes mellitus, prediabetic state, hyperglycemia, insulin resistance, public healthAbstract
Introduction: It has been suggested that the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) could serve as an additional test to support and complement existing tests for hyperglycemic states.
Objective: To determine the diagnostic capacity of HOMA-IR for Type 2 diabetes mellitus (T2DM) and prediabetes.
Methods: Diagnostic test study. Both were measured according to elevated fasting; postprandial, and glycosylated hemoglobin levels. The receiver operating characteristic curve (ROC) along with its corresponding area under the curve (AUC) was used to evaluate diagnostic efficacy. Sensitivity and specificity metric were calculated.
Results: The prevalence of prediabetes and T2DM were 18.82% and 10.52%, respectively. The median HOMA-IR was 1.33. HOMA-IR had an AUC of 0.843 for prediabetes in the total population, with a cutoff point of 1.51, a sensitivity of 88.37%, and a specificity of 73.05%. In the case of T2DM, the AUC was 0.907, with a cutoff point of 2.02, a sensitivity of 90.91%, and a specificity of 77.99%.
Conclusions: HOMA-IR demonstrates good diagnostic capability for the detection of prediabetes and T2DM.
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