Trends in acute myocardial infarction between 2018-2021
Keywords:
heart disease, ischemia, myocardial infarctionAbstract
Background: Acute myocardial infarction (AMI) is a high incidence heart disease with impact on hospital morbidity and mortality, common cause of admissions and care in emergency units.
Objective: To describe the annual behavior of AMI.
Methods: Analytical observational study in 1253 patients admitted for AMI in the period 01/01/2018 to 31/12/2021, at the Saturnino Lora Hospital in Santiago de Cuba. The following variables were used: age, sex, hospital stay, discharge status, use of homeopathic formulations, and location of the ischemic lesion. For the statistical analysis, the normality of the data distribution was evaluated, Fischer and Welch t-tests, chi-square, Log-rank test and Kaplan-Meier curves were used.
Results: 67.99% of patients were male. The overall case fatality was 10.21%. Significant differences in age (62.63 ± 0.73 vs. 71.43 ± 2.04; p= 0.0000) and hospital stay (7.92 ± 0.33 vs. 3.19 ± 0.66; p= 0.0000) were observed between live vs. deceased discharged patients. Of the deaths, 57.03% occurred within 48 hours, 32.81% within 24 hours and 19.53% within 12 hours of hospital admission. Using homeopathic formulations was associated with a clinically significant protective effect.
Conclusions: Incidence increased in 2020, with a tendency to recover at the end of the period evaluated; inverse trend in relation to mortality; a clinically significant protective effect was identified in the use of homeopathic formulations.
Downloads
References
República de Cuba. Ministerio de Salud Pública, Dirección de Registros Médicos y Estadísticas de Salud [Internet]. Anuario Estadístico de Salud 2021. La Habana: MINSAP. 2022. [acceso: 17/04/2024]. Disponible en: https://instituciones.sld.cu/ucmvc/files/2023/10/Anuario-Estad%C3%ADstico-de-Salud-2022-Ed-2023.pdf
Vitón-Castillo A, Piñera-Castro H, Guillén-León L, Montes-de-Oca-Carmenaty M, Suárez-López D, Auza-Santiváñez J. Tendencias en la producción científica cubana sobre infarto agudo de miocardio en Scopus [Internet]. Universidad Médica Pinareña. 2022 [acceso: 25/05/2024]; 18(2):e891. Disponible en: https://revgaleno.sld.cu/index.php/ump/article/view/891
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M. Acute Myocardial Infarction in Young Individuals [Internet]. Mayo Clinic proceedings. 2020; 95(1):136-56. DOI: 10.1016/j.mayocp.2019.05.001
Humphries KH, Norris CM, Pilote L. Sex Differences in Acute Myocardial Infarction: Good News and Bad News [Internet]. The Canadian journal of cardiology. 2022; 38(11):1661-3. DOI: 10.1016/j.cjca.2022.08.227
Centers for Disease Control and Prevention. Heart Disease Facts [Internet]. Centers for Disease Control and Prevention. 2023. [acceso: 15/04/2024]. Disponible en: https://www.cdc.gov/heartdisease/facts.htm
Michaud K, Basso C, d'Amati G, Giordano C, Kholová I, Preston SD, et al. Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification [Internet]. Virchows Archiv: an international journal of pathology. 2020; 476(2):179-94. DOI: 10.1007/s00428-019-02662-1
Damluji AA, Gangasani NR, Grines CL. Mechanical Complication of Acute Myocardial Infarction Secondary to COVID-19 Disease [Internet]. Heart failure clinics. 2023; 19(2):241-9. DOI: 10.1016/j.hfc.2022.08.011
Cerón A, Goldstein G. Mortality due to acute myocardial infarction in Guatemala 2018: patterns and inequities [Internet]. Analysis of National Reality Magazine, University of San Carlos of Guatemala. 2018 [acceso: 18/04/2024 ]; 10(201):76-97. Disponible en: http://ipn.usac.edu.gt/wp-content/uploads/2021/03/IPN-RD-201.pdf
Samsky MD, Morrow DA, Proudfoot AG, Hochman JS, Thiele H, Rao SV. Cardiogenic Shock After Acute Myocardial Infarction: A Review [Internet]. JAMA. 2021; 326(18):1840-50. DOI: 10.1001/jama.2021.18323
DeFilippis AP, Lidani KCF, Nam Y, Trainor PJ, Johnson WC, Heckbert SR, et al. Risk factor associations with individual myocardial infarction subtypes and acute non-ischemic myocardial injury in the Multi-Ethnic Study of Atherosclerosis (MESA): Design and rationale [Internet]. Am Heart J. 2023; 260:151-73. DOI: 10.1016/j.ahj.2023.02.012 ?
Ojha N, Dhamoon AS. Myocardial Infarction [Internet]. Treasure Island (FL): StatPearls Publishing. 2024 [acceso: 18/04/2024]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30725761/
Salari N, Morddarvanjoghi F, Abdolmaleki A, Rasoulpoor S, Khaleghi AA, Hezarkhani LA, et al. The global prevalence of myocardial infarction: a systematic review and meta-analysis [Internet]. BMC Cardiovasc Disord. 2023; (1):206. DOI: 10.1186/s12872-023-03231-w
Pichardo-Ureña J, Pérez-Sánchez D, Alonso-Herrera A. Caracterización de la mortalidad por infarto agudo de miocardio con elevación del segmento ST en el Hospital Arnaldo Milián Castro (Cuba): Estudio de 6 años [Internet]. CorSalud. 2020 [acceso: 17/04/2024]; 12(3):e693. Disponible en: https://revcorsalud.sld.cu/index.php/cors/article/view/693
Rosabal-Garcia Y, Pérez-Infante Y, Rosales-Guibert E, Palacios-Naranjo Y. Caracterización clinicoepidemiológica, ecocardiográfica y terapéutica de pacientes con infarto agudo de miocardio [Internet]. MEDISAN. 2023 [acceso: 17/04/2024]; 27(2):e4381. 15. Disponible en: https://medisan.sld.cu/index.php/san/article/view/4381
World Medical Association. Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Participants [Internet]. JAMA. 2024;23(18): e21972. DOI: 10.1001/jama.2024.21972
Organización Panamericana de la Salud. IV Conferencia Panamericana sobre Armonización de la Reglamentación Farmacéutica. República Dominicana 2-4 marzo, 2005. Conclusiones y recomendaciones [Internet]. OPS; 2005. [acceso: 20/04/2024]. Disponible en: https://www.paho.org/es/documentos/iv-conferencia-panamericana-sobre-armonizacion-reglamentacion-farmaceutica-republica-0
Mechanic OJ, Gavin M, Grossman SA. Acute Myocardial Infarction [Internet]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 [acceso: 17/04/2024]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29083808/
Wu X, Reboll MR, Korf-Klingebiel M, Wollert KC. Angiogenesis after acute myocardial infarction [Internet]. Cardiovasc Res. 2021; 117(5):1257-73. DOI: 10.1093/cvr/cvaa287
Bhatt DL, Lopes RD, Harrington RA. Diagnosis and Treatment of Acute Coronary Syndromes: A Review [Internet]. JAMA. 2022; 327(7):662-75. DOI: 10.1001/jama.2022.0358
Birnbaum Y, Rankinen J, Jneid H, Atar D, Nikus K. The Role of ECG in the Diagnosis and Risk Stratification of Acute Coronary Syndromes: an Old but Indispensable Tool [Internet]. Curr Cardiol Rep. 2022; 24(2):109-18. DOI: 10.1007/s11886-021-01628-7
Webb JG, Sleeper LA, Buller CE, et al. Implicaciones del momento de aparición del shock cardiogénico después de un infarto agudo de miocardio: un informe del Registro de ensayos SHOCK [Internet]. J Am Coll Cardiol. 2000; 36(3):1084-90. DOI: 10.1016/S0735-1097(00)00876-7pp1084-1090
Mnatzaganian G, Braitberg G, Hiller JE, Kuhn L, Chapman R. Sex differences in in-hospital mortality following a first acute myocardial infarction: symptomatology, delayed presentation, and hospital setting [Internet]. BMC Cardiovasc Disord. 2016; 16(1):109. DOI: 10.1186/s12872-016-0276-5
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Documento de consenso de expertos. Tercera definición universal del infarto de miocardio [Internet]. Rev Esp Cardiol. 2013 [acceso: 20/04/2024]; 66(2):132.e1-e15. Disponible en: https://www.academia.edu/download/89640938/index.pdf
Nguyen HL, Bui QT, Tran HV, Hoang MV, Le TT, Ha DA, et al. Characteristics, in-hospital management, and complications of acute myocardial infarction in northern and Central Vietnam [Internet]. Int J Cardiol. 2022 [acceso: 20/04/2024]; 364:133-8. Disponible en: https://www.sciencedirect.com/science/article/pii/S0167527322009-433?via%3Dihub
Wereski R, Kimenai DM, Bularga A, Taggart C, Lowe DJ, Mills NL, et al. Risk factors for type 1 and type 2 myocardial infarction [Internet]. Eur Heart J. 2022 [acceso: 20/04/2024]; 43(2):127-35. Disponible en: https://academic.oup.com/eurheartj/article/43/2/127/6357312?login=false
Gómez J. Predictores de mortalidad intrahospitalaria en infarto agudo al miocardio con elevación del segmento ST [Internet]. Rev Med (Col Méd Cir Guatem). 2022 [acceso: 20/04/2024]; 161(1):16-23. Disponible en: https://www.revistamedicagt.org/index.php/RevMedGuatemala/artic-le/view/451/631
García Blas S, Cordero A, Diez Villanueva P, Martínez Avial M, Ayesta A, Ariza Sole A, et al. Acute coronary syndrome in the older patient [Internet]. J Clin Med. 2021; 10(18):4132. DOI: 10.3390/jcm10184132
Creagh Cazull A, Cazull Imbert I, Márquez Fernández A, Hernández Heredia R, Delfino Vega EL. Factores predictores de mortalidad hospitalaria en pacientes con infarto agudo del miocardio [Internet]. Rev Inf Cient. 2021 [acceso: 23/04/2024]; 100(2):e3339. Disponible en: https://revinfcientifica.sld.cu/index.php/ric/article/view/3339
Santos Medina M, Borrero Escobar EM, Cruz Fernández Y, Rodríguez Ramos M, Martínez García G, Mata Cuevas LA. Infarto agudo de miocardio en pacientes diabéticos según niveles de glucemia al ingreso, un estudio multicéntrico [Internet]. Electron Rev "Dr. Zoilo E. Marinello Vidaurreta". 2022 [acceso: 20/04/2024]; 47(4):e3148. Disponible en: https://revzoilomarinello.sld.cu/index.php/zmv/article/view/3148
Enamorado Anaya AR, Yero García RO, Ruiz Manzanares A, García Cañete IM, Goro G. Factores pronósticos de mortalidad intrahospitalaria en pacientes con infarto agudo del miocardio con elevación del segmento ST tipo I [Internet]. Rev Inf Cient. 2021 [acceso: 20/04/2024]; 100(1):e3248. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-99332021000100005
Palacio Pérez H, Rey García KB, Castillo Cuello JJ. Factores pronósticos de fallo de trombólisis en pacientes con diagnóstico de infarto agudo de miocardio [Internet]. Medicentro Electrónica. 2022 [acceso: 20/04/2024]; 26(4):853-65. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432022000400853
Golikov AP, Babaian IS. Pumpan pri lechenii ishemicheskoi bolezni serdtsa v sochetanii s arterial'noi gipertoniei. Pumpan in the treatment of ischemic heart disease associated with arterial hypertension [Internet]. Ter Arkh. 2001 [acceso: 20/04/2024]; 73(10):68-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11763522/
Krasnitskii VB, Aronov DM, Zhidko NI. Vliianie complex preparation "Pumpan" in perenosimost' fizicheskikh nagruzok i klinicheskoe techenie ishemicheskoi bolezni serdtsa [Effect of a compound preparation pumpan on exercise tolerance and clinical course of ischemic heart disease] [Internet]. Ter Arkh. 2003 [acceso: 20/04/2024]; 75(8):17-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/14520844/
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Héctor José Pérez Hernández, Rubén David Román Robert, Katherine Susana Hernández Cortés

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who have publications with this Journal accept the following terms:
- The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
- The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
- Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.