Primary duodenal lymphoma

Authors

Keywords:

non-Hodgkin lymphoma, marginal zone B-cell lymphoma, MALT lymphoma

Abstract

Introduction: Primary duodenal lymphoma is an extremely rare entity affecting older male patients and usually has a poor prognosis.

Objective: To describe the clinical presentation and clinicopathological characteristics of primary duodenal lymphoma of mucosa-associated lymphoid tissue.

Clinical case: 63-year-old male patient with nonspecific gastrointestinal symptoms, diagnosed with primary duodenal lymphoma, an extremely rare location. This case stands out for its rarity, the importance of differential diagnosis and the use of endoscopic and histopathological tools to identify this poorly documented entity.

Conclusions: Primary duodenal lymphoma is an extremely rare neoplasm. It is crucial to differentiate it from other intestinal lymphomas in relation to its morphological, histopathological and immunophenotypic characteristics.

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References

1. Iwamuro M, Tanaka T, Okada H. Review of lymphoma in the duodenum: An update of diagnosis and management [Internet]. World J Gastroenterol. 2023; 29(12):1852-1862. DOI: 10.3748/wjg.v29.i12.1852

2. Zheng G, Wang Y, Zhao Y, Zheng Z. Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis [Internet]. Can J Gastroenterol Hepatol. 2020; 9327868:1-4. DOI: 10.1155/2020/9327868

3. Bautista-Quach MA, Ake CD, Chen M, Wang J. Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features [Internet]. J Gastrointest Oncol. 2012; 3(3):209-25. DOI: 10.3978/j.issn.2078-6891.2012.024

4. Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [Internet]. Leukemia. 2023; (9):1944-51. DOI: 10.1038/s41375-023-01962-5

5. Di Rocco A, Petrucci L, Assanto GM, Martelli M, Pulsoni A. Extranodal Marginal Zone Lymphoma: Pathogenesis, Diagnosis and Treatment [Internet]. Cancers. 2022; 14(7):1742. DOI: 10.3390/cancers14071742

6. Raderer M, Kiesewetter B, Du MQ. Clinical relevance of molecular aspects in extranodal marginal zone lymphoma: a critical appraisal [Internet]. Ther Adv Med Oncol. 2023; 15:17588359231183565. DOI: 10.1177/17588359231183565

7. Shirwaikar Thomas A, Schwartz M, Quigley E. Gastrointestinal lymphoma: the new mimic [Internet]. BMJ Open Gastroenterol. 2019; 6(1):e000320. DOI: 10.1136/bmjgast-2019-000320

8. Na HK, Won SH, Ahn JY, Kim GH, Jung KW, Lee JH, et al. Clinical course of duodenal mucosa-associated lymphoid tissue lymphoma: Comparison with gastric mucosa-associated lymphoid tissue lymphoma [Internet]. J Gastroenterol Hepatol. 2021; 36(2):406-12. DOI: 10.1111/jgh.15157

9. Ishikawa E, Nakamura M, Satou A, Shimada K, Nakamura S. Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era [Internet]. Cancer. 2022; 14(2):446-9. DOI: 10.3390/cancers14020446

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Published

2025-10-10

How to Cite

1.
Alburqueque-Melgarejo J, Beltrán-Gárate B, Vela-Ruiz JM, Cotrina Montenegro EG de los M, Kapsoli Sanchez M del C. Primary duodenal lymphoma. Rev. cuba. med. mil [Internet]. 2025 Oct. 10 [cited 2026 Feb. 12];54(4):e025076346. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/76346

Issue

Vol. 54 No. 4 (2025): October - December

Section

Case Presentation

License

Copyright (c) 2025 Joseph Alburqueque-Melgarejo, Brady Beltrán-Gárate, José Manuel Vela-Ruiz, Esther Graciela de los Milagros Cotrina Montenegro, Maria del Carmen Kapsoli Sanchez

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