Percutaneous ethanol injection as first-line treatment for benign nontoxic multinodular goiter

Authors

Keywords:

ethanol, nodular goiter, treatment

Abstract

Introduction: Multinodular goiter is one of the most common diagnoses in endocrine surgery. The symptoms of this condition are primarily due to the enlargement of the nodules.

Objective: To evaluate percutaneous ethanol injection as first-line treatment in patients diagnosed with benign nontoxic multinodular goiter.

Methods: A longitudinal, prospective study was conducted in 75 patients with a diagnosis of benign nontoxic multinodular goiter and 85 nodules treated with percutaneous ethanol injection. Qualitative variables were described as absolute frequencies and percentages, and numerical variables as means and standard deviations. Student's t test for related samples was used to assess changes in initial and final nodule volumes.

Results: The mean total volume of ethanol injected was 13.42 ± 11.06 mL; with 3.53 ± 2.67 treatment sessions per nodule. The efficacy of the technique was 100% and clinical success was complete in 100% of patients at 12 months post-treatment follow-up. The side effects that occurred were burning (43.5%), transient dysphonia (2.4%) and moderate pain (4.7%). No complications occurred.

Conclusions: Percutaneous ethanol injection as first-line treatment in patients with benign nontoxic multinodular goiter is safe and effective, guarantees clinical success and avoids surgical treatment in these patients.

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Author Biographies

Lazaro Lorda Galiano, Universidad de Ciencias Medicas de las Fuerzas Armadas Revolucionarias

Universidad de Ciencias Medicas de las Fuerzas Armadas Revolucionarias

Jacinto O. Navas Igarza, Universidad de Ciencias Médicas de las Fuerzas Armadas Revolucionarias. Hospital Militar Central “Dr. Carlos J. Finlay”. La Habana, Cuba.

Universidad de Ciencias Médicas de las Fuerzas Armadas Revolucionarias. Hospital Militar Central “Dr. Carlos J. Finlay”. La Habana, Cuba.

Leandro Yero Brea, Universidad de Ciencias Médicas de las Fuerzas Armadas Revolucionarias. Hospital Militar Central “Dr. Carlos J. Finlay”. La Habana, Cuba.

Universidad de Ciencias Médicas de las Fuerzas Armadas Revolucionarias. Hospital Militar Central “Dr. Carlos J. Finlay”. La Habana, Cuba.

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Published

2025-06-07

How to Cite

1.
Lorda Galiano L, Navas Igarza JO, Yero Brea L. Percutaneous ethanol injection as first-line treatment for benign nontoxic multinodular goiter. Rev Cubana Med Milit [Internet]. 2025 Jun. 7 [cited 2025 Jun. 13];54(2):e025076361. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/76361

Issue

Vol. 54 No. 2 (2025): April - June (In Progress)

Section

Clinical Practice Article

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Copyright (c) 2025 Lazaro Lorda Galiano, Jacinto O. Navas Igarza, Leandro Yero Brea

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