Patient with chromomycosis and inserted squamous cell carcinoma
Keywords:
chromomycosis, squamous cell carcinoma, itraconazoleAbstract
Introduction: Chromomycosis is a chronic, granulomatous subcutaneous mycosis caused by dermatiaceous fungi, which most commonly affects adults between the second and sixth decades of life. It is acquired through transcutaneous trauma, which allows fragments of hyphae and conidia to penetrate the skin.
Objective: To present a patient with chromomycosis, an attached squamous cell carcinoma, successfully treated with surgery and systemic antifungal therapy.
Clinical Case: A 77-year-old male patient with phototype I and severe sun damage, with a plaque-like lesion on the right forearm suggestive of chromomycosis and an attached squamous cell carcinoma. Antifungal treatment with itraconazole and excision of the tumor were indicated. Six months later, no recurrence was observed.
Conclusions: Reports of chromomycosis associated with squamous cell carcinoma are rare, a complication in long-standing, untreated lesions. However, in this patient it appeared in short-term lesions.
Downloads
References
1. Wattiez V, García J, Aquino N, Insaurralde S, Mendoza G, Celias Luis, et al. Cromomicosis: casuística del Servicio de Dermatología del Hospital Nacional, periodo 1991- 2015 [Internet]. Rev. virtual Soc. Parag. Med. Int. 2017; 4(2): 27-33. DOI: 10.18004/rvspmi/2312-3893/2017.04(02)27-033
2. González M, Morales S, Morales T. Cromomicosis. Presentación de un paciente [Internet]. Medicentro Electrónica. 2013 [acceso: 08/10/2024]; 17(3):133-7. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432013000300008&lng=es
3. Ventura R, Failoc V, Silva H. Cromoblastomicosis: características clínicas y microbiológicas de una enfermedad desatendida [Internet]. Rev. chil. infectol. 2017;34(4):404-7. DOI: 10.4067/s0716-10182017000400404
4. García D, López M, Adjudah C. Diagnóstico microbiológico en un paciente con cromomicosis [Internet]. Medicentro Electrónica. 2020 [acceso: 20/01/2025]; 24 (3):691-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432020000300691&lng=es
5. Muñoz V, Rochin M, Rubio M, Omaña M, Rodríguez J. Micetoma y cromoblastomicosis simultáneamente. Reporte de un caso [Internet]. Med Cutan Iber Lat Am. 2021 [acceso: 18/08/2022]; 49(1):46-50. Disponible en: https://hospital.uas.edu.mx/dermatologia/01.%20Articulos/Art.%202021%20Caromo-%20micetoma.pdf
6. Marques SG, Bomfim MRQ, Azevedo C de MPS, Martins CVB, Marques ACG, Goncalves AG, et al. Mixed secondary bacterialinfection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil [Internet]. Diagn Microbiol Infect Dis. 2019; 95(2):201-7. DOI: 10.1016/j.diagmicrobio.2019.05.018
7. Larrondo RJ, Gray O, Abreu A, Bonito D. Cromomicosis. Estudio de un decenio. Hospital Universitario Comandante Manuel Fajardo. 1996-2005 [Internet]. Folia Dermatol Cubana. 2009 [acceso: 26/07/2013]; 3(2): [aprox. 8 p.]. Disponible en: http://www.bvs.sld.cu/revistas/fdc/vol3_2_09/fdc07209.htm
8. Wang Y, Yiwen Wang, Yuhang Zhou Y. Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment [Internet]. Cancer Biol Med. 2024. 21(11):977-94. DOI: 10.20892/j.issn.2095-3941.2024.0240
9. Jahr C, Peruilh L, Jiménez M, Bobadilla F, Segovia L. Cromoblastomicosis. Primer caso alóctono tratado en Chile [Internet]. Rev Chilena Infectol. 2022 [acceso: 08/08/2022]; 39(3):349-53. Disponible en: https://www.revinf.cl/index.php/revinf/article/view/1378/767
10. Burstein Z. Cromomicosis: Clínica y tratamiento; situación epidemiológica en Latinoamérica [Internet]. Rev. perú. med. exp. salud pública. 2004 [acceso: 15/01/2025]; 21(3): 167-75. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342004000300008&lng=es
11. Collazo H, González E, Pardillo AG, Collazo Y. Amputación interescapulotorácica por cromomicosis y carcinoma epidermoide [Internet]. Rev Cubana Ortop Traumatol. 2001 [acceso: 08/10/2024]; 15(1-2): 27-31. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-215X2001000100004&lng=es
12. Simran S, Ejaj K. P. Intratumor fungi specific mechanisms to influence cell death pathways and trigger tumor cell apoptosis [Internet]. Cell Death Discovery. 2025; 11:188. DOI: 10.1038/s41420-025-02483-z
13. Flores SL, Ferrá T, Florat D, Gabriel Y. Cromomicosis: presentación de un caso [Internet]. Revista Archivo Médico de Camagüey. 2018 [acceso: 18/08/2022]; 22(2):224-30. Disponible en: https://www.redalyc.org/journal/2111/211159713012/html/
14. Botello, HM, Vanden en den L, Jaramillo F, Marulanda MA. Cromomicosis, una enfermedad tropical olvidada [Internet]. Rev Asoc Colomb Dermatol. 2021 [acceso: 18/08/2022]; 29(1):45-55. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/1590
15. Queiróz AJR, Pereira F, Antônio JR. Chromoblastomycosis: clinical experience and review of literature [Internet]. Int J Dermatol. 2018; 57(1):1351-5. DOI: 10.1111/ijd.14185
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Yudilsa Sánchez García, Jessica Milagros Silvente Alarcón, Midalys Casa de Valle Castro, Marlenis Pérez Bruzón, Bettsy Martínez Cardoso
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who have publications with this Journal accept the following terms:
- The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
- The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
- Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.
