Epidemiological, clinical and mycological characterization of severely ill neonates with candidemia due to Candida parapsilosis complex

Authors

Keywords:

Candida parapsilosis, candidemia, infant, newborn

Abstract

Introduction: Candida parapsilosis complex represents a serious threat to newborns, with an increase in resistance to antifungal sused for treatment.

Objective: To characterize the epidemiology, clinical symptoms and mycology of critically ill neonates with candidemia due to the C. parasilosis complex.

Methods: An observational, descriptive, cross-sectional study of newborns hospitalized in acute care units at two provincial institutions from May 2022 to December 2024. Epidemiological variables were analyzed, including patient sex, month, season and hospital; and mycological variables included sensitivity and resistance to antifungal tested. Absolute frequencies and percentages were calculated.

Results: Of the 30 newborns with candidemia due to C. parapsilosis complex, 76.7% were female.  April was the most representative month with 11 isolates, followed by December with four. 66.7% of infections occurred between November and April, which corresponds to the coldest months, and women are the most affected population group. 26.7% of patients died, and of these, 62.5% were from the Gynecological-obstetric Hospital, with gender equality in both institutions. The highest levels of susceptibility were to amphotericin B (90%).

Conclusions: Female neonates with candidemia, diagnosed primarily during the winter season, predominanted; despite the high mortality rate, clinical isolates sensitive to amphotericin B prevailed.

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References

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Published

2025-09-12

How to Cite

1.
González Lorenzo L, García Gómez D, Hernández del Sol CR, Perurena Lancha MR, González Madariaga Y. Epidemiological, clinical and mycological characterization of severely ill neonates with candidemia due to Candida parapsilosis complex. Rev. cuba. med. mil [Internet]. 2025 Sep. 12 [cited 2026 Feb. 13];54(3):e025076555. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/76555

Issue

Vol. 54 No. 3 (2025): July - September

Section

Clinical Practice Article

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Copyright (c) 2025 Liena González Lorenzo, Dianiley García Gómez, Calixta Rosa Hernández del Sol, Mayda Rosa Perurena Lancha, Yisel González Madariaga

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