Early postoperative respiratory complications in liver transplant patients according to the Clavien-Dindo classification
Keywords:
liver transplantation, mechanical ventilation, pneumoniaAbstract
Introduction: Liver transplantation is the treatment of choice for end-stage chronic liver diseases and acute liver failure. Although its outcomes are favorable, postoperative complications can occur, including surgical and medical ones, among them respiratory complications.
Objective: To characterize the severity of respiratory complications according to the Clavien-Dindo classification in the early postoperative period of patients undergoing liver transplantation.
Methods: Descriptive, observational study of a series of 66 patients who underwent liver transplantation with respiratory complications, from July 1999 to April 2019, in the intensive care unit of the Center for Medical-Surgical Research. Variables described include age, sex, pretransplant indications, types of respiratory complications, severity of complications according to Clavien-Dindo, duration of mechanical ventilation, and length of stay in the intensive care unit.
Results: Pneumonia was the most frequent respiratory complication (32; 39.5%). Severe complications occurred in 45 (68.0%) patients, the majority of whom were male (34; 77.2%). Alcoholic cirrhosis was the most frequent etiology among severe patients (18; 90%), with longer durations of mechanical ventilation (40; 75.4%) and intensive care unit stay (42; 82.3%).
Conclusions: Respiratory complications negatively influence the postoperative evolution of liver transplant patients. The Clavien-Dindo classification standardizes the severity in a simple and practical way, and therefore should be applied systematically to optimize outcomes in surgical services.
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References
1. Cervantes E, Vilanova M, Limon N, Méndez O, Kershenobich D, Torre A, et al. Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience [Internet]. World J Gastroenteric. 2022; 28(40): 5881-92. DOI: 10.3748/wjg.v28.i40.5881
2. Feltracco P, Carollo C, Barbieri S, Pettenuzzo T, Ori C. Early respiratory complications after liver transplantation [Internet]. World J Gastroenterology. 2013; 19: 9271-81. DOI: 10.3748/wjg. v19.i48.9271
3. Agostini A, Boin IFSF, Heidemann A, Tonella RM, Falcão ALE, Ratti LSR, et al. Risk factors for reintubation related to non-airway failure after liver transplantation in intensive care unit: observational study [Internet]. BJT. 2022; 25(01): e0222. DOI: 10.53855/bjt. v25i1.425
4. Solarana Ortiz JA. Clasificación de las complicaciones posoperatorias ¡Un tema controversial! [Internet]. Rev. Cub. Cir. 2023 [acceso: 16/06/2025]; 61(4): 1-3. Disponible en: https://revcirugia.sld.cu/index.php/cir/article/view/1458
5. Avolio AW, Gaspari R, Teofili L, Bianco G, Spinazzola G, Soave PM, et al. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis [Internet]. PLoS ONE. 2019; 14(2): e0211678. DOI: 10.1371/journal.pone.0211678
6. Lui JK, Spaho L, Holzwanger E, Bui R, Daly JS, Bozorgzadeh A, et al. Intensive care of pulmonary complications following liver transplantation [Internet]. J Intensive Care Med. 2018; 33(11): 595-608. DOI: 10.1177/0885066618757410
7. Wang Y, Ning Z, Yang L, Wang T. Construction and validation of a pulmonary complication score for patients after liver transplantation [Internet]. Trasplante Clin. 2023; 37(3): e14872. DOI: 10.1111/ctr.14872
8. Bravo LG, Coelho GR, Campos MFA, Girão ES, Parente JH, et al. Risk factors associated pneumonia in post operative early liver transplant [Internet]. J Bras Transpl. 2015 [acceso: 16/06/2025]; 18(1): 1-33. Disponible en: https://bjt.emnuvens.com.br/revista/article/view/120/109
9. Zhang S, An R, Liu L, Xue M, Li JP, Wang Q, et al. The effect of perioperative fluid therapy on early postoperative pulmonary complications after orthotopic liver transplantation [Internet]. Chinese Journal of Surgery. 2019; 57(6): 440-6. DOI: 10.3760/cma.j.issn.0529-5815.2019.06.009
10. Ripoll J, Wanta B, Wetzel D, Frank R, Findlay J, Vogt M. Association of perioperative variables and the acute respiratory distress syndrome in liver transplant recipients [Internet]. Transplantation Direct. 2020; 6(1): e520. DOI: 10.1097/TXD.0000000000000965
11. Gómez F, Abdo A, Castellanos R, Espinosa N, Leal G, Díaz G. Pulmonary complications in patients with liver transplant [Internet]. Invest Medicoquir. 2016. [acceso: 01/06/2024]; 7(2): 212-25. Disponible en: https://revcimeq.sld.cu/index.php/imq/article/view/321
12. Cuk N, Melamed K, Vangala S, Salah R, Miller WD, Swanson S, et al. Postoperative trapped lung after orthotopic liver transplantation is a predictor of increased mortality [Internet]. Transpl Int. 2022; 35: 10387. DOI: 10.3389/ti.2022.10387
13. Clavien PA, Sanabria JR, Strasberg SM. Proposed classification of complications of surgery with examples of utility in cholecystectomy [Internet]. Surgery. 1992 [acceso: 01/06/2024]; 111(5): 518-26. Disponible en: https://pubmed.ncbi.nlm.nih.gov/1598671/
14. Dindo D, Demartines N, Clavien PA. Clasificación de complicaciones quirúrgicas: una nueva propuesta con evaluación en una cohorte de 6336 pacientes y resultados de una encuesta [Internet]. Ann Surg. 2004; 240(2): 205-13. DOI: 10.1097/01.sla.0000133083.54934.ae
15. Grijalva OB, Garrido J, Murcia F, Ibarra M, Paredes R. Clasificación de Clavien-Dindo. Herramienta para evaluar las complicaciones tras el tratamiento quirúrgico en niños con apendicitis aguda [Internet]. Cir Pediatr. 2022; 35(1): 18-24. DOI: 10.54847/cp.2022.01.04
16. Soufi M, FlickK F, Ceppa DP, Blackwell MB, Mararu R, Nguyen TK, et al. Investigating the incidence, impact, and severity of pulmonary complications after hepatectomy: A single institution experience [Internet]. Surgery 2022; 171(3): 643-9. DOI: 10.1016/j.surg.2021.12.016
17. Lai Q, Melandro F, Nowak G, Nicolini D, Lesari S, Fasolo E, et al. The role of the comprehensive complication index for the prediction of survival after liver transplantation [Internet]. Updates in Surgery. 2021; 73(1): 209-21. DOI: 10.1007/s13304-020-00878-4
18. Ray S, Mehta NN, Mangla V, Lalwani S, Mehrotra S, ChughP, et al. A comparison between the comprehensive complication index and the Clavien-Dindo grading as a measure of postoperative outcome in patients undergoing gastrointestinal surgery-a prospective study [Internet]. J Surg Res. 2019; 244: 417-24. DOI: 10.1016/j.jss.2019.06.093
19. Kalisvaart M, de Haan JE, Polak WG, Metselaar HJ, Wijnhoven BPL, IJzermans JNM, et al. Comparison of postoperative outcomes between donation after circulatory death and donation after brain death liver transplantation using the comprehensive complication index [Internet]. Ann Surg. 2017; 266(5): 772-8. DOI: 10.1097/SLA.0000000000002419
20. World Medical Association. World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Participants [Internet]. JAMA. 2025;333(1):71–4. DOI: 10.1001/jama.2024.21972
21. Saiman Y, Serper M. Frailty and sarcopenia in patients pre- and post-liver transplant [Internet]. Clin Liver Dis. 2021; 25(1): 35-51. DOI: 10.1016/j.cld.2020.08.004
22. Chen C, Yang D, Gao S, Zhang Y, Chen L, Wang B, et al. Development and performance assessment of novel machine learning models to predict pneumonia after liver transplantation [Internet]. Respir Res. 2021; 22(1): 94. DOI: 10.1186/s12931-021-01690-3
23. Avolio AW, Gaspari R, Teofili L, Bianco G, Spinazzola G, Soave PM, et al. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis [Internet]. PLoS ONE. 2019; 14(2): e0211678. DOI: 10.1371/journal.pone.0211678
24. Wiering L, Sponholz F, Brandl A, Dziodzio T, Jara M, Dargieet R, et al. Perioperative pleural drainage in liver transplantation [Internet]. Ann Transplant, 2020; 25: e918456. DOI: 10.12659/AOT.918456
25. Graf J, Cornejo R, Acuña D, Bugedo G. Expanded definition of the acute respiratory distress syndrome (ARDS) [Internet]. Rev Chil Med Intensiv. 2022 [acceso: 05/08/2024]; 37(1): 09-11. Disponible en: https://www.medicina-intensiva.cl/revista/pdf/76/51.pdf
26. Castanedo S, Toledo E, Fernández-Santiago R, Castillo F, Echeverri J, Rodríguez-Sanjuá JC. Influence of postoperative complications on long-term survival in liver transplant patients [Internet]. World J Gastrointest Surg. 2020; 12(8): 336-45. DOI: 10.4240/wjgs.v12.i8.336
27. Golder H, Casanova D, Papalois V. Evaluation of the usefulness of the Clavien-Dindo classification of surgical complications [Internet]. Cirugía Española. 2023; 101(9): 637-42. DOI: 10.1016/j.ciresp.2023.01.012
28. Hernández V, García JM, Zamudio A, García I, Avila JA. Liver transplantation in Mexican older adults: A comparative single-center study [Internet]. Revista de Gastroenterología de México. 2019; 84(4): 455-60. DOI: 10.1016/j.rgmx.2018.09.003
29. Zhou D, Zhang D, Zeng C, Zhang L, Gao X, Wang X. Impact of sarcopenia on the survival of patients undergoing liver transplantation for decompensated liver cirrhosis [Internet]. The Journal of Cachexia, Sarcopenia and Muscle. 2023; 14(6): 2602-12. DOI: 10.1002/jcsm.13334
30. Wang D, Zhang J, Bai Z, Yang Y, Wang T, Jin L, et al. Associations of postoperative complications assessed by Clavien-Dindo classification and comprehensive complication index with long-term overall survival in elderly patients after radical CRC resection [Internet]. Clin Interv Aging. 2020;15: 1939-49. DOI: 10.2147/CIA.S271969
31. Ángeles U, Velázquez Y, Molinar F, Anaya VE, Uribe SE. Estimación de la estancia adicional en pacientes con infección hospitalaria [Internet]. Rev Médica Inst Mex Seguro Soc. 2009; [acceso: 05/08/ 2024]; 47(4): 387-92. Disponible en: https://www.medigraphic.com/pdfs/imss/im-2009/im094h.pdf
32. Álvarez S, Escobar SM, Ochoa LC. Estancia prolongada en hospitalización, descripción en literatura y análisis para su manejo [Internet]. [Tesis de Especialización en gerencia de IPS]. Colombia, Medellín: Universidad CES, Facultad de Medicina; 2020. [acceso: 12/09/2024]. Disponible en: https://repository.ces.edu.co/server/api/core/bitstreams/a69a2e4c-1e55-4b79-9cee-3fc7ed8889f6/content
33. Xu Y, Zuo Y, Zhou L, Hao X, Xiao X, Ye M, et al. Extubation in the operating room results in fewer composite mechanical ventilation-related adverse outcomes in patients after liver transplantation: a retrospective cohort study [Internet]. BMC Anesthesiol. 2021;21(1): 286. DOI: 10.1186/s12871-021-01508-1
34. Acho C, Morita Y, Fernandez V, Safwan M, Galusca D, Abouljoud M. Immediate postoperative extubation decreases pulmonary complications in liver transplant patients [Internet]. Transplantation. 2021; 105(9): 2018-28. DOI: 10.1097/TP.0000000000003450
35. Haque M, Badenoch A, Selzner M, McCluskey SA. Predicting early extubation after liver transplantation: external validation and improved generalizability of a proposed fast-track score [Internet]. Transplantation. 2021; 105(9): 2029-36. DOI: 10.1097/TP.0000000000003452
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Copyright (c) 2025 Francisco Gómez Peire, Anselmo A. Abdo Cuza, Marcia Samada Suárez, Lisset Barroso Márquez, Carmen Elena Viada González, Milidza Ayllón Castañera

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