Pigmented nodular malignant melanoma

Authors

Keywords:

melanomas, malignant melanoma, neoplasms

Abstract

Introduction: Melanomas are malignant tumors that originate in melanocytes, highly differentiated cells that originate in the neural crest and are responsible for melanin synthesis.

Objective: To present a clinical case of nodular malignant melanoma, its characteristics, early diagnosis, and timely treatment.

Clinical Case: A 59-year-old white female patient with no prior medical history presented to a dermatology clinic with a lesion on the sole of her right foot. Physical examination revealed a 3 cm diameter tumor with raised, well-defined borders, central ulceration, a black color, and a two-month history. A diagnosis of pigmented nodular malignant melanoma was made clinically and histologically, with a favorable response to surgical and chemotherapeutic treatment.

Conclusions: The likelihood of surviving nodular melanoma depends on the size and depth of the primary tumor, as well as the difficulty of curing it when detected in advanced stages. To achieve early detection, preventive measures need to be implemented, aimed at increasing the training of health personnel and the population, in relation to the warning signs of a pigmented lesion and its evolution to malignant melanoma.

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References

1. Hernandez LE, Frech FS, Mohsin N, Dreyfuss I, Nouri K. Nodular Melanoma: A Review of Pathogenesis, Presentation, Diagnosis, and Treatment [Internet]. J Dermatol & Skin Sci. 2021;3(3):25-30. DOI: 10.29245/2767-5092/2021/3.1144

2. Dhanyamraju PK, Patel TN. Melanoma therapeutics: a literature review [Internet]. J Biomed Res. 2022; 36(2):77-97. DOI: 10.7555/JBR.36.20210163

3. Pozzobon FC, Acosta AE, Castillo JS. Cáncer de piel en Colombia: cifras del Instituto Nacional de Cancerología [Internet]. Rev Asoc Colomb Dermatol Cir Dematol. 2018 [acceso: 18/08/2024];26(1):12-7. Disponible en: https://revista.asocoldderma.org.co/index.php/asocolderma/article/view/254

4. Ospina AV, Contreras- Mejía F, Yepes- Peréz A, Lehmann C, Bobadilla - Arévalo IA, Lema- Medicina M, et al. Diagnóstico y tratamiento multidisciplinario de melanoma temprano y localmente avanzado. Consenso de expertos. Asociación Colombiana de Hematología y Oncología (ACHO) [Internet]. Rev Colomb Cancerol. 2021 [acceso: 18/08/2024]; 25(4):196-209. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123_90152021000400196&Ing=en

5. Ramamoorthy T, Nath A, Singh S, Mathew S, Pant A, Sheela S, et al. Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis [Internet]. CO Global Oncol. 2024; 10:e2300427. DOI: https://doi.org/10.1200/GO.23.00427

6. Zemelman V, Garmendia ML,Kirschbaum A. Malignant melanoma mortality rates in Chile (1988-98) [Internet]. Int J Dermatol. 2002; 41:99-103. DOI: 10.1046/j.1365-4362.2002.01421.x

7. Zemelman V, Kirschbaum A. Mortality from malignant melanoma in Chile, 1986-95 [Internet]. The British Journal of Dermatology. 1998; 139(6): 1111-12. DOI: 10.1046/j.1365-2133.1998.2576b.x

8. Corneli P, Zalaudek I, Magaton Rizzi G, di Meo N. Improving the early diagnosis of early nodular melanoma: can we do better? [Internet]. Expert Rev Anticancer Ther. 2018; 18 (10): 1007-12. DOI: 10.1080/14737140.2018.1507822

9. Hind Selman-Housein Bernal K, Tárano Quintero G, Morales Pérez Il, Alfonso Sabatier C, Hernández Bernal F. Tumor gigante en un paciente con melanoma [Internet]. Rev Cubana Med. 2012 [acceso: 20/06/2023]; 51(2): 183-90. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext & pid=S0034-75232012000200009 & Ing=es

10. Nova J, Acosta Á, Toquica A, GU – Quiñones S, Gutiérrez LD, Montero A. Melanoma Lentiginoso Acral Revisión Narrativa de uno de los melanomas más Frecuentes en América Latina [Internet]. Rev Colomb Cancerol. 2021 [acceso:18/08/2024]; 25(3): 140-53. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123-90152021000300140&Ing=en

11. Schwartz AR. Melanoma maligno y diagnóstico diferencial de lesiones pigmentadas en piel [Internet]. Rev Méd Clin Las Condes. 2011; 22(6), 728-34. DOI: 10.1016/S0716-8640(11)70485-0

12. Blanco Córdova CA. Melanoma nodular en borde de pie [Internet]. Rev Ciencias Médicas. 2014 [acceso: 18/08/2024]; 18(2):329–36. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942014000200016&Ing=es

13. García Wong H, González Rodríguez Z, López Vergara M. Melanoma en la región frontal [Internet]. Rev FDC. 2012 [acceso: 18/06/2023]; 6(2): [aprox. 5 pant.]. Disponible en: http://www.bvs.sld.cu/revistas/fdc/vol6_2_12/fdc01212.htm

14. Goodson AG, Grossman D. Strategies for early melanoma detection: Approaches to the patient with nevi. J Am Acad Dermatol. 2009; 60(5):719-35. DOI: 10.1016/j.jaad.2008.10.065

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Published

2026-03-02

How to Cite

1.
Mora Escalona EE, Cuervo Bauste J de J, Infante Beatón AR, García Masso D. Pigmented nodular malignant melanoma. Rev. cuba. med. mil [Internet]. 2026 Mar. 2 [cited 2026 Mar. 3];55(1):e026076705. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/76705

Issue

Vol. 55 No. 1 (2026): January - March (In progress)

Section

Case Presentation

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Copyright (c) 2026 Estrella Esther Mora Escalona, Juan de Jesús Cuervo Bauste, Alejandro Rafael Infante Beatón, Dunia García Masso

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