Association between cadmium concentrations in blood, thyroid tissue and stage of thyroid cancer

Authors

Keywords:

association, cadmium, thyroid cancer

Abstract

Introduction: The etiology of thyroid cancer remains unclear. Previous studies have supported the hypothesis that cadmium, may contribute to the development of thyroid cancer.

Objectives: To assess cadmium concentrations in thyroid tissue and blood samples, and to evaluate the association between these concentrations and thyroid cancer state.

Methods: A descriptive cross-sectional study was conducted on 282 patients who underwent partial or total thyroidectomy at Cho Ray Hospital. Cadmium concentrations in blood and tissue were determined. The association between Cadmium in blood, thyroid tissue and thyroid cancer stage was assessed by a logistic regression model.

Results: Cadmium levels in blood and tissue samples were higher in patients with cancer tumor node metastasis stage (TNM) stage 2 and 4 compared to stage 1. Logistic regression analysis showed that blood cadmium in the TNM stage 2 and 4 groups were significantly higher than those in stage 1 group (OR = 1.355; 95% CI: 1.176–1.56; p < 0.001). Elevated cadmium levels in thyroid tissue were also positively associated with TNM stages 2 and 4 compared to stage 1 (OR = 1.005; 95% CI: 1.001–1.008; p = 0.007).

Conclusion: Cadmium concentrations in thyroid tissue and blood samples are associated with thyroid cancer stage.

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Published

2025-11-14

How to Cite

1.
Lam Nguyen Nha Truc, Nguyen Thi Thu Trang, Le Tuan Anh, Hoang Thi Truong, Nguyen Van Chuyen, Nguyen Van Bang, et al. Association between cadmium concentrations in blood, thyroid tissue and stage of thyroid cancer. Rev. cuba. med. mil [Internet]. 2025 Nov. 14 [cited 2026 Feb. 12];54(4):e025076911. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/76911

Issue

Vol. 54 No. 4 (2025): October - December

Section

Research Article

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Copyright (c) 2025 Lam Nguyen Nha Truc, Nguyen Thi Thu Trang, Tuấn Anh Lê, Hoang Thi Truong, Nguyen Van Chuyen, Nguyen Van Bang, Nguyen Thi Minh Ngoc, Tran Quang Phuc, Nguyen Van Ba, Ta Quang Thanh

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