Multiple and recurrent pilomatricoma in a pediatric patient
Keywords:
diagnosis; pediatric; pilomatricoma; recurrence; skin neoplasmsAbstract
Introduction: Pilomatricoma is a rare, benign skin tumor, with an estimated frequency of 1% among all skin tumors. It primarily affects the head and neck region, particularly in the pediatric population. While multiple pilomatricomas are uncommon and represent 0.7–3% of all cases, recurrent ones are even rarer and require special attention when managing this benign skin tumor.
Objective: To report a pediatric case of multiple and recurrent pilomatricomas, emphasizing its clinical characteristics diagnostic challenges, and therapeutic decisions.
Clinical Case: A 12-year-old male patient with multiple pilomatricomas since the age of six, who had previously undergone five surgical excisions. Currently, new tumors have emerged on his neck and thigh, steadily increasing in size. The lesions were subcutaneous, mobile, and non-painful, with no associated systemic symptoms or neurological conditions. Pathological examination and soft tissue ultrasonography confirmed the diagnosis of multiple and recurrent pilomatricoma, and a new surgical intervention was scheduled.
Conclusion: The patient developed more than seven tumors over a six-year period—a pattern uncommon in published pediatric cohorts. Recognizing the specific characteristics of multiple and recurrent pilomatricomas in pediatric patients is essential for accurate and timely diagnosis.
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1. Hu JL, Yoo H, Kwon ST, Kim S, Chung JH, Kim H, et al. Clinical analysis and review of literature on pilomatrixoma in pediatric patients [Internet]. Arch Craniofac Surg. 2020;21(5):288–93. DOI: 10.7181/acfs.2020.00528
2. Mohr C, Tschen J. Atypical pediatric presentation of pilomatricoma [Internet]. Cureus. 2023;15(6):e39909. DOI: 10.7759/cureus.39909
3. Lu C, Zhang R, Bi L, Luo T, Lai W, Fan W, Jing H. Clinical Features, Diagnostic Challenges, and Therapeutic Outcomes of 105 Pilomatricoma Cases [Internet]. Clin Cosmet Investig Dermatol. 2025;18:1801-1807. DOI: 10.2147/CCID.S518408
4. Chan JJ, Tey HL. Multiple pilomatricomas: case presentation and review of the literature [Internet]. Dermatol Online J. 2010;16(4):2. DOI: 10.5070/D31td0145c
5. Mesa-Álvarez L, Batalla A, Iglesias-Puzas Á, Álvarez C, Flórez Á. Multiple pilomatricomas: a retrospective study and literature review [Internet]. Am J Dermatopathol. 2019;41(4):293–5. DOI: 10.1097/DAD.0000000000001296
6. Chessa MA, Baracca MF, Rossi AN, Piraccini BM, De Pietro V, Picciola VM, et al. Pilomatricoma: Clinical, Dermoscopic Findings and Management in 55 Pediatric Patients and Concise Review of the Literature with Special Emphasis on Dermoscopy [Internet]. Dermatol Pract Concept. 2024;14(2):e2024140. DOI: 10.5826/dpc.1402a140
7. Bulman JC, Ulualp SO, Rajaram V, Koral K. Pilomatricoma of Childhood: A Common Pathologic Diagnosis Yet a Rare Radiologic One [Internet]. American Journal of Roentgenology. 2015;206(1):182–8. DOI:10.2214/AJR.15.14842
8. Saponaro G, De Paolis E, Todaro M, Azzuni F, Gasparini G, Bosso A, et al. Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome [Internet]. Dermatopathology. 2025;12(3):24. DOI: 10.3390/dermatopathology12030024
9. Cornejo KM, Deng A. Pilomatrix carcinoma: a case report and review of the literature [Internet]. Am J Dermatopathol. 2013;35(3):389–94. DOI: 10.1097/DAD.0b013e318274b7da
10. Dang J, Sun J, Wang W, Zhang Y. Pilomatricoma in the right parotid region: A case report and review of the literature [Internet]. Asian J Surg. 2023;46(6):2393-2394. DOI: 10.1016/j.asjsur.2022.12.029
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Copyright (c) 2026 Ariana Alexandra Campos Castillo, Fabiola Fernanda Saravia Yataco, Victor Fernando Maximiliano Vargas Uribe, José Salvador Carrillo, Johan Manuel Espino Ortiz, Cindy Elizabeth Alcarraz Molina

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