Publique un comentario 
La relación entre IDH, mutaciones P53, metilación de MGMT con las caracterÃsticas de pacientes con glioma de alto grado
Resumen
Objetivos: Describir las caracterÃsticas y asociaciones de IDH, mutaciones del gen TP53 y estado de metilación de MGMT con algunas caracterÃsticas y respuesta al tratamiento en pacientes con glioma de alto grado.
Métodos: Se realizó un estudio descriptivo, prospectivo no controlado, en 52 pacientes con glioma de alto grado. Las variables investigadas fueron: edad, sexo, puntuación de Karnofsky, tasa de IDH, mutación P53, estado de metilación de MGMT, relación entre la mutación de genes con algunas caracterÃsticas y la respuesta al tratamiento según la clasificación RECIST.
Resultados: Mutación del gen IDH: los pacientes grado III (23,1 %) tienen una tasa positiva más alta que los grado IV (11,5 %). Mutación del gen P53: los grado III (55,6 %) tienen una tasa positiva más alta que los grado IV (44,1 %). La tasa de metilación del promotor de MGMT se produjo con una tasa del 42,3 %. Existe relación entre la mutación del gen IDH con los resultados patológicos y la malignidad. Los pacientes con la expresión mutante del gen IDH, p53, estado de metilación de MGMT tuvieron mejores respuestas RECIST.
Conclusión: El glioma de alto grado se presenta principalmente en hombres, mayores de 40 años. La presencia de mutaciones en los genes IDH, P53 y el estado de metilación de MGMT fue un factor beneficioso para la respuesta al tratamiento según lo evaluado por RECIST.
Palabras clave
Referencias
Ostrom QT, Liao P, Stetson LC, Jill SB. Chapter 2 - Epidemiology of Glioblastoma and Trends in Glioblastoma Survivorship. In: Brem S, Abdullah KG. Glioblastoma. Philadelphia: Elsevier; 2016. [access: 06/12/2016]. Available at: https://www.sciencedirect.com/science/article/pii/B978032347660700002-1?via%3Dihub
Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP. Years of life lost (YLL) from cancer is an important measure of population burden—and should be considered when allocating research funds. British Journal of Cancer. 2005 [access: 06/12/2016]; 92: 241-5. Available at: https://www.nature.com/articles/6602321
Stupp R, Warren PM, Martin JB, Weller M, Barbara F, Martin JBT, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal Medicine. 2005 [access: 06/12/2016]; 352(10): 987-96. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa043330
Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, et al. Malignant glioma: genetics and biology of a grave matter. Genes & Development. 2001 [access: 01/06/2001]; 15(11): 1311-33. Available at: http://genesdev.cshlp.org/content/15/11/1311.long
Ollivier L, Padhani AR. The RECIST criteria: implications for diagnostic radiologists. The British Journal of Radiology. 2001 [access: 14/05/2001]; 74(887): 983–6. Available at: http://recist.com.br/PDF/Artigo%20RECIST.pdf
Rasmussen BK, Hansen S, Laursen RJ, Kosteljanetz M, Schultz H, Nørgård BM, et al. Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I–IV in the the Danish Neuro-Oncology Registry. Journal of Neuro-Oncology. 2017 [access: 31/08/2017]; 135(3):571–9. Available at: https://pubmed.ncbi.nlm.nih.gov/28861666/
Hoffman S, Propp JM, McCarthy BJ. Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol. 2006 [access: 01/01/2006]; 8(1):27-37. Available at: https://pubmed.ncbi.nlm.nih.gov/16443945/
Ho J, Ondos J, Ning H, Smith S, Kreisl T, Iwamoto F, et al. Chemoirradiation for Glioblastoma Multiforme: The National Cancer Institute Experience. PLoS ONE. 2013 [access: 05/08/2013]; 8(8): e70745. Available at: https://pubmed.ncbi.nlm.nih.gov/23940635/
Ichimura K, Pearson DM, Kocialkowski S, Bäcklund LM, Chan R, Jones DT, et al. IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol. 2009 [access: 01/08/2009]; 11(4): 341-7. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743214/
Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008 [access: 05/12/2008]; 116(6): 597-602. Available at: https://pubmed.ncbi.nlm.nih.gov/18985363/
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. New England Journal of Medicine. 2009 [access: 19/02/2009]; 360(8): 765-73. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820383/
Turkalp Z, Karamchandani J, Das S. IDH mutation in glioma: new insights and promises for the future. JAMA Neurol. 2014 [access: 25/08/2014]; 71(10):1319-25. Available at: https://jamanetwork.com/journals/jamaneurology/fullarticle/1897092
Cairncross JG, Wang M, Jenkins RB, Shaw EG, Giannini C, Brachman DG, et al. Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol. 2014 [access: 10/03/2014]; 32(8):783-90. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940537/
Tada M, Iggo RD, Waridel F, Nozaki M, Matsumoto R, Sawamura Y, et al. Reappraisal of p53 mutations in human malignant astrocytic neoplasms by p53 functional assay: comparison with conventional structural analyses. Molecular Carcinogenesis. 1997 [access: 01/03/1997]; 18(3):171-6. Available at: https://pubmed.ncbi.nlm.nih.gov/9115587/
Baker SJ. Redefining p53 – entering the tumor suppressor era. Cell Cycle. 2003 [access: 01/01/2003]; 2(1):7-8. Available at: https://www.tandfonline.com/doi/pdf/10.4161/cc.2.1.288
Faria MH, Neves Filho EH, Alves MK, Burbano RM, de Moraes Filho MO, Rabenhorst SH. TP53 mutations in astrocytic gliomas: an association with histological grade, TP53 codon 72 polymorphism and p53 expression. APMIS. 2012; 120(11):882-9. DOI: 10.1111/j.1600-0463.2012.02918.x
Watanabe K, Sato K, Biernat W, Tachibana O, von Ammon K, Ogata N, et al. Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies. Clinical Cancer Research. 1997 [access: 01/03/1997]; 3(4):523-30. Available at: https://aacrjournals.org/clincancerres/article/3/4/523/8205/Incidence-and-timing-of-p53-mutations-during
Zawlik I, Kita D, Vaccarella S, Mittelbronn M, Franceschi S, Ohgaki H. Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas. Brain Pathol. 2009 [access: 01/03/2009]; 19(2):188-94. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094731/
Barnholtz-Sloan J, Sloan AE, Land S, Kupsky W, Monteiro AN. Somatic alterations in brain tumors. Oncol Rep. 2008 [access: 01/07/2008]; 20(1):203-10. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933973/
Blough MD, Beauchamp DC, Westgate MR, Kelly JJ, Cairncross JG. Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma. J Neurooncol. 2011 [access: 01/03/2011]; 102(1):1-7. Available at: https://link.springer.com/article/10.1007/s11060-010-0283-9
Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, Wick W, et al. MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol. 2010 [access: 01/01/2010]; 6(1):39-51. Available at: https://www.nature.com/articles/nrneurol.2009.197
Friedman HS, McLendon RE, Kerby T, Dugan M, Bigner SH, Henry AJ, et al. DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. J Clin Oncol. 1998 [access: 01/12/1998]; 16(12):3851-7. Available at: https://ascopubs.org/doi/pdf/10.1200/JCO.1998.16.12.3851
Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, et al. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 2014 [access: 01/08/2014]; 15(9):e395-403. Available at: https://www.zora.uzh.ch/id/eprint/98103/
Stupp R, Brada M, van den Bent MJ, Tonn JC, Pentheroudakis G. High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014 [access: 01/09/2014]; 25 (Suppl 3):iii93-101. Available at: https://www.annalsofoncology.org/article/S0923-7534(19)34077-3/fulltext
Enlaces refback
- No hay ningún enlace refback.
URL de la licencia: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es
La revista es de acceso abierto y gratuito.