Obesidad en adultos mayores con déficit de vitamina D: revisión sistemática y metanálisis

Leyla Rodas Alvarado, Víctor Juan Vera-Ponce, Jenny Raquel Torres-Malca, Jesús Enrique Talavera, Fiorella E. Zuzunaga-Montoya, Jhony A. De La Cruz-Vargas

Texto completo:

HTML PDF XML

Resumen

Introducción: La obesidad y el déficit de vitamina D son alteraciones que están presentes en el adulto mayor, pero su asociación entre ambos no está del todo claro.
Objetivo: Determinar la asociación entre obesidad y el déficit de vitamina D en población adulta mayor.
Métodos: Revisión sistemática de estudios observacionales. La búsqueda se realizó en Pubmed/Medline, SCOPUS, Web of Science, Cochrane Library y EMBASE. La obesidad fue medida a través a través del índice de masa corporal y cintura abdominal; el déficit de vitamina D, por la 25-hidroxi-vitamina D. Estos datos se combinaron con un modelo de efectos aleatorios y las medidas de asociación se calcularon a través del el odds ratio (OR). La heterogeneidad se midió según el I cuadrado.
Resultados: Cinco estudios fueron incluidos (n= 17 700. Se encontró asociación entre la vitamina D con la obesidad según índice de masa corporal (OR= 1,36; IC95 %: 1,04-1,77) y según cintura abdominal abdominal (OR=1,74; IC95 %: 1,26-2,40. La heterogeneidad de los efectos entre los estudios fue de moderada a alta.
Conclusiones: Se encuentra asociación entre la presencia de obesidad y el déficit de vitamina D en la población anciana.

Palabras clave

obesidad; circunferencia de la cintura; índice de masa corporal; vitamina D; revisión sistemática.

Referencias

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019; 92:6-10. DOI 10.1016/j.metabol.2018.09.005

Donini LM, Rosano A, Di Lazzaro L, Lubrano C, Carbonelli M, Pinto A, et al. Impact of Disability, Psychological Status, and Comorbidity on Health-Related Quality of Life Perceived by Subjects with Obesity. Obes Facts. 2020;13(2):191-200. DOI:10.1159/000506079

Kalish VB. Obesity in Older Adults. Prim Care. 2016;43(1):137-44. DOI: 10.1016/j.pop.2015.10.002

Ding L, Liang Y, Tan ECK, Hu Y, Zhang C, Liu Y, et al. Smoking, heavy drinking, physical inactivity, and obesity among middle-aged and older adults in China: cross-sectional findings from the baseline survey of CHARLS 2011-2012. BMC Public Health. 2020;20(1):1062. DOI: 10.1186/s12889-020-08625-5

Instituto Nacional de Salud. Ministerio de Salud. Alimentación y Nutrición. Vigilancia del Estado Nutricional en Población. [acceso: 16/09/2021]. Disponible en: http://web.ins.gob.pe/es/alimentacion-y-nutricion/vigilancia-alimentaria-y-nutricional/vigilancia-del-estado-nutricional-en-poblacion

Cetin DC, Nasr G. Obesity in the elderly: more complicated than you think. Cleve Clin J Med. 2014; 81(1):51-61. DOI: 10.3949/ccjm.81a.12165

Jensen GL. Obesity and functional decline: epidemiology and geriatric consequences. Clin Geriatr Med. 2005; 21(4):677-87. DOI: 10.1016/j.cger.2005.06.007

Shapiro H, Pecht T, Shaco-Levy R, Harman-Boehm I, Kirshtein B, Kuperman Y, et al. Adipose tissue foam cells are present in human obesity. J Clin Endocrinol Metab. 2013; 98(3):1173-81. DOI: 10.1210/jc.2012-2745

Neale RE, Khan SR, Lucas RM, Waterhouse M, Whiteman DC, Olsen CM. The effect of sunscreen on vitamin D: a review. Br J Dermatol. 2019; 181(5):907-15. DOI: 10.1111/bjd.17980

Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014; 111(1):23-45. DOI: 10.1017/S0007114513001840

van Schoor N, Lips P. Global Overview of Vitamin D Status. Endocrinol Metab Clin North Am. 2017; 46(4):845-70. DOI: 10.1016/j.ecl.2017.07.002

Marcos-Pérez D, Sánchez-Flores M, Proietti S, Bonassi S, Costa S, Teixeira JP, et al. Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12(8):E2286. DOI: 10.3390/nu12082286

Segheto KJ, Pereira M, Silva DCG da, Carvalho CJ de, Massardi FR, Kakehasi AM, et al. Vitamin D and bone health in adults: a systematic review and meta-analysis. Cien Saude Colet. 2021; 26(8):3221-44. DOI: 10.1590/1413-81232021268.15012020

Lucato P, Solmi M, Maggi S, Bertocco A, Bano G, Trevisan C, et al. Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis. Maturitas. 2017; 100:8-15. DOI: 10.1016/j.maturitas.2017.02.016

Okereke OI, Singh A. The role of vitamin D in the prevention of late-life depression. J Affect Disord. 2016; 198:1-14. DOI: 10.1016/j.jad.2016.03.022

Yang J, Ou-Yang J, Huang J. Low serum vitamin D levels increase the mortality of cardiovascular disease in older adults: A dose-response meta-analysis of prospective studies. Medicine (Baltimore). 2019; 98(34): e16733. DOI:10.1097/MD.0000000000016733

Apovian CM. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. 2016 [acceso: 16/09/2021]; 22(7 Suppl):s176-185.. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27356115/

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. DOI: 10.1371/journal.pmed.1000097

Modesti PA, Reboldi G, Cappuccio FP, Agyemang C, Remuzzi G, Rapi S, et al. Panethnic Differences in Blood Pressure in Europe: A Systematic Review and Meta-Analysis. PLOS ONE. 2016; 11(1):e0147601. DOI: 10.1371/journal.pone.0147601

Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane; 2022. [acceso: 27/11/2021]. Disponible en: https://training.cochrane.org/handbook

Zhu X-L, Chen Z-H, Li Y, Yang P-T, Liu L, Wu L-X, et al. Associations of vitamin D with novel and traditional anthropometric indices according to age and sex: a cross-sectional study in central southern China. Eat Weight Disord. 2020; 25(6):1651-61. DOI: 10.1007/s40519-019-00803-8

Cheng Q, Du Y, Hong W, Tang W, Li H, Chen M, et al. Factors associated to serum 25-hydroxyvitamin D levels among older adult populations in urban and suburban communities in Shanghai, China. BMC Geriatr. 2017; 17(1):246. DOI: 10.1186/s12877-017-0632-z

Orces C, Lorenzo C, Guarneros JE. The Prevalence and Determinants of Vitamin D Inadequacy among U.S. Older Adults: National Health and Nutrition Examination Survey 2007-2014. Cureus. 2019; 11(8):e5300. DOI:10.7759/cureus.5300

Orces CH, López Gavilánez E. Determinants of vitamin D supplementation among older adults and its effect on 25(OH)D levels according to bone mineral density status. Nutr Hosp. 2020;37(1):28-36. DOI: 10.20960/nh.02917

Sousa-Santos AR, Afonso C, Santos A, Borges N, Moreira P, Padrão P, et al. The association between 25(OH)D levels, frailty status and obesity indices in older adults. PLoS One. 2018; 13(8):e0198650. DOI: 10.1371/journal.pone.0198650

Mathus-Vliegen EM. Obesity and the Elderly. Journal of Clinical Gastroenterology. 2012; 46(7):533-44. DOI: 10.1097/MCG.0b013e31825692ce

Gažarová M, Galšneiderová M, Mečiarová L. Obesity diagnosis and mortality risk based on a body shape index (ABSI) and other indices and anthropometric parameters in university students. Rocz Panstw Zakl Hig. 2019; 70(3):267-75. DOI: 10.32394/rpzh.2019.0077

Vieth R, Holick MF. Chapter 57B - The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position. En: Feldman D, editor. Vitamin D (Fourth Edition). Academic Press; 2018. p109:107. DOI: 10.1016/B978-0-12-809965-0.00059-8

Graham L. IOM Releases Report on Dietary Refernce Intakes for Calcium and Vitamin D. AFP. 2011 [acceso: 27/11/2021]; 83(11):1352. Disponible en: http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx

Ross R, Freeman JA, Janssen I. Exercise alone is an effective strategy for reducing obesity and related comorbidities. Exerc Sport Sci Rev. 2000 [acceso: 27/11/2021]; 28(4):165-70. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11064850/

Valentini A, Perrone MA, Cianfarani MA, Tarantino U, Massoud R, Merra G, et al. Obesity, vitamin D status and physical activity: 1,25(OH)2D as a potential marker of vitamin D deficiency in obese subjects. Panminerva Med. 2020; 62(2):83-92. DOI: 10.23736/S0031-0808.20.03770-2

González-Molero I, Rojo-Martínez G, Morcillo S, Gutierrez C, Rubio E, Pérez-Valero V, et al. Hypovitaminosis D and incidence of obesity: a prospective study. Eur J Clin Nutr. 2013; 67(6):680-2. DOI: 10.1038/ejcn.2013.48

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690

Agarwal S, Tooze JA, Bauer DC, Cauley JA, Harris TB, Koster A, et al. Association between 25-Hydroxyvitamin D and Metabolic Syndrome in Older Adults: The Health, Aging and Body Composition Study. Int J Endocrinol. 2021; 2021: 6671823. DOI: 10.1155/2021/6671823

Awad AB, Alappat L, Valerio M. Vitamin d and metabolic syndrome risk factors: evidence and mechanisms. Crit Rev Food Sci Nutr. 2012; 52(2):103-12. DOI: 10.1080/10408391003785458

Drincic AT, Armas LAG, Van Diest EE, Heaney RP. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012; 20(7):1444-8. DOI: 10.1038/oby.2011.404

Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J. 2001; 15(14):2751-3. DOI: 10.1096/fj.01-0584fje

Pereira M, Ribas de Farias Costa P, Miranda Pereira E, Russoni de Lima Lago I, Marlucia Oliveira A. Does vitamin D deficiency increase the risk of obesity in adults and the elderly? A systematic review of prospective cohort studies. Public Health. 2021; 190:123-31 DOI: 10.1016/j.puhe.2020.04.031

Enlaces refback

  • No hay ningún enlace refback.




URL de la licencia: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es