Concentración y valor del dímero D en el diagnóstico de trombosis venosa profunda

Van Nguyen-Thanh Phan, De Nhi Nguyen, Tri Dang-Minh Bui, Minh Duc Tong, Trung Hoang Nguyen, Dung Thi-Ngoc Nguyen

Resumen

Introducción: La cuantificación de los niveles de dímero D es una prueba valiosa para orientar el diagnóstico de trombosis venosa profunda.
Objetivos: Determinar la concentración de dímero D y el valor diagnóstico del dímero D en pacientes con trombosis venosa profunda.
Métodos: Se realizó un estudio descriptivo, no controlado, en 260 pacientes ancianos con riesgo de trombosis venosa profunda. Todos los pacientes se sometieron a un ensayo cuantitativo de dímero D.
Resultados: La concentración de dímero D de los pacientes con trombosis venosa profunda tuvo una mediana de 3106,5 ng/mL y fue aproximadamente 1,5 veces mayor que la de los pacientes sin trombosis venosa profunda. Con un umbral de concentración de dímero D de 500 ng/mL, para determinar la trombosis venosa profunda, la especificidad del método es baja (16,51 %), pero la sensibilidad es alta (100 %). El valor predictivo positivo es bajo (18,75 %) pero el valor predictivo negativo es absoluto (100 %).
Conclusión: Con un umbral de concentración de dímero D de 500 ng/mL para determinar la trombosis venosa profunda, la especificidad y el valor predictivo positivo del método son bajos, pero la sensibilidad y el valor predictivo negativo son altos.

Palabras clave

concentración de dímero D; valor diagnóstico de dímero D; trombosis venosa profunda.

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