Cambios en los niveles de marcadores inmunológicos después del tratamiento en pacientes con rinitis alérgica

Nam Thanh Quan, Thuan Duc Nghiem, Thuc Minh Vu, Huong Lan Do, Cuong Anh Nguyen

Resumen

Introducción: El monitoreo de los cambios en los niveles de marcadores inmunes es de gran importancia para evaluar la efectividad del tratamiento en pacientes con rinitis alérgica.
Objetivos: Determinar el cambio en la concentración de marcadores inmunes después del tratamiento, en pacientes con rinitis alérgica causada por polvo de algodón.
Métodos: Estudio descriptivo, monogrupo, comparativo antes y después de la intervención, en 52 pacientes con rinitis alérgica por polvo de algodón. Se compararon resultados de marcadores inmunológicos antes y después de 36 meses de tratamiento.
Resultados: La concentración de IgE total después del tratamiento disminuyó, la mediana disminuyó de 1227,756 U/mL a 676,805 UI/mL. Los niveles séricos de IgG, IgG4 e IgG1 en pacientes, después del tratamiento, aumentaron (p< 0,001). Las citocinas también cambiaron en dirección a ausencia de respuesta a la alergia. La mediana de IL-17 disminuyó de 1,752 mg/dL a 0,417 mg/dL.
Conclusión: En pacientes con rinitis alérgica, después del tratamiento específico de desensibilización sublingual, los niveles de IgE y citocinas como IL-6 e IL-17 se reducen significativamente y los niveles de IgG, IgG4 e IgG1 aumentan.

Palabras clave

rinitis alérgica; polvo de algodón; IgE; IgG; citoquinas.

Referencias

Yuan Z, Luo Z. Increasing prevalence of allergic rhinitis in China. Allergy, asthma & immunology research. 2019; 11(2):156-69. DOI: 10.4168/aair.2019.11.2.156

Passali D, Cingi C, Staffa P, Passali F, Muluk NB, Bellussi ML. The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. Asia Pacific Allergy. 2018; 8(1):e7. DOI: 10.5415/apallergy.2018.8.e7

Muluk NB, Bafaqeeh SA, Cingi C. Anti-IgE treatment in allergic rhinitis. International Journal of Pediatric Otorhinolaryngology. 2019; 127:109674. DOI: 10.1016/j.ijporl.2019.109674

Alamri RA, Aljabri GH, Tahlawi R, Aljabri HA, Aljabri SGH. Immunotherapy in the Treatment of Allergic Rhinitis in Children. Cureus. 2022; 14(12):e32464. DOI: 10.7759/cureus.32464

Gabet S, Rancière F, Just J, de Blic J, Lezmi G, Amat F, Momas I. Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children. World Allergy Organization Journal. 2019;12(9): 100057. DOI: 10.1016/j.waojou.2019.100057

Thuan HQ. Research on standardization of allergen Dermatophagoides Pteronyssinus and its application in the diagnosis and specific immunotherapy of allergic rhinitis [Ph.D thesis]. Hanoi: Vietnam Military Medical University; 2012. [access: 27/04/2012]. Available at: http://luanan.nlv.gov.vn/luanan?a=d&d=TTcFlGvGViZi2012.1.1

Smoldovskaya O, Feyzkhanova G, Voloshin S, Arefieva A, Chubarova A, Pavlushkina L, et al. Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases. World Allergy Organization Journal. 2018; 11:35. DOI: 10.1186/s40413-018-0220-5

Demš ar LA, Korošec P, Košnik M, Zidarn M, Rijavec M. Hymenoptera venom immunotherapy: immune mechanisms of induced protection and tolerance. Cells. 2021; 10(7):1575. DOI: 10.3390/cells10071575

Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. Journal of Allergy and Clinical Immunology. 2005; 116(3):608-13. DOI: 10.1016/j.jaci.2005.06.004

Queirós MG, Silva DA, Siman IL, Ynoue LH, Araújo NS, Pereira FL, et al. Modulation of mucosal/systemic antibody response after sublingual immunotherapy in mite-allergic children. Pediatric Allergy and Immunology. 2013; 24(8):752-61. DOI: 10.1111/pai.12163

Stylianou E, Ueland T, Borchsenius F, Michelsen AE, Øvstebø R, Eirik MT, et al. Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian journal of clinical and laboratory investigation. 2016; 76(2):118-27. DOI: 10.3109/00365513.2015.1110856

Scadding G. Cytokine profiles in allergic rhinitis. Current allergy and asthma reports. 2014; 14:1-8. DOI: 10.1007/s11882-014-0435-7

Hofmann MA, Fluhr JW, Ruwwe-Glösenkamp C, Stevanovic K, Bergmann KC, Zuberbier T. Role of IL-17 in atopy-A systematic review. Clinical and Translational Allergy. 2021; 11(6): e12047. DOI: 10.1002/clt2.12047

Qiu Q, Lu H, Lu C, Chen S, Han H. Variations in TGF-beta, IL-10, and IL-17 after specific immunotherapy and correlations with symptoms in patients with allergic rhinitis. Journal of investigational allergology & clinical immunology. 2012 [access: 01/10/2014]; 22(4):311-2. Available at: https://pubmed.ncbi.nlm.nih.gov/22812212/

Bachus H, McLaughlin E, Lewis C, Papillion AM, Benveniste EN, Hill DD, León B, et al. IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling. Cellular & Molecular Immunology. 2023; 1-15. DOI: 10.1038/s41423-023-01012-1

Goswami TK, Singh M, Dhawan M, Mitra S, Emran TB, Rabaan AA, Dhama K, et al. Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders-Advances and challenges. Human Vaccines & Immunotherapeutics. 2022; 18(1):2035117. DOI: 10.1080/21645515.2022.2035117

Wan Z, Zhou Z, Liu Y, Lai Y, Luo Y, Peng X, et al. Regulatory T cells and T helper 17 cells in viral infection. Scandinavian Journal of Immunology. 2020; 91(5):e12873. DOI: 10.1111/sji.12873

Gao S, Yu L, Zhang J, Li X, Zhou J, Zeng P, et al. Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis. Annals of Palliative Medicine. 2021; 10:4516-22. DOI: 10.21037/apm-21-546

Barberi S, Villa MP, Pajno GB, La Penna F, Barreto M, Cardelli P, et al. Immune response to sublingual immunotherapy in children allergic to mites. Journal of biological regulators and homeostatic agents. 2011 [access: 01/10/2011]; 25(4):627-34. Available at: https://europepmc.org/article/med/22217994

Bayrak DP, Aksun S, Altin Z, Bilgir F, Arslan IB, Colak H, et al. Allergic rhinitis and its relationship with IL-10, IL-17, TGF-ß, IFN-?, IL 22, and IL-35. Disease markers. 2018; 2018:1-6. DOI: 10.1155/2018/9131432

Song L, Luan B, Xu QR, Wang XF. Effect of TLR7 gene expression mediating NF-?B signaling pathway on the pathogenesis of bronchial asthma in mice and the intervention role of IFN-?. Eur Rev Med Pharmacol Sci. 2021; 25(2):866-79. DOI: 10.26355/eurrev_202101_24655

Xie S, Fan R, Tang Q, Cai X, Zhang H, Wang F, et al. Identification of robust biomarkers for early predicting efficacy of subcutaneous immunotherapy in children with house dust mite-induced allergic rhinitis by multiple cytokine profiling. Frontiers in Immunology. 2022; 12: 5866. DOI: 10.3389/fimmu.2021.805404

Liu X, Ng CL, De YW. The efficacy of sublingual immunotherapy for allergic diseases in Asia. Allergology International. 2018; 67(3):309-19. DOI: 10.1016/j.alit.2018.02.007

Enlaces refback

  • No hay ningún enlace refback.


URL de la licencia: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es