Changes in the levels of immunological markers after treatment in patients with allergic rhinitis
Keywords:
allergic rhinitis, cotton dust, IgE, IgG, cytokines.Abstract
Introduction: Monitoring changes in the levels of immune markers is of great significance in evaluating the effectiveness of treatment in patients with allergic rhinitis.Objectives: Determine the change in the concentration of immune markers after treatment in patients with allergic rhinitis caused by cotton dust.
Methods : A descriptive, single-group, comparative before and after intervention study on 52 patients with allergic rhinitis caused by cotton dust. Comparison of immunological markers results before and after 36 months of treatment.
Results: Total IgE concentration after treatment decreased, the median decreased from 1227.756 U/mL to 676.805 UI/mL. Serum levels of IgG, IgG4, and IgG1 in patients after treatment increased compared to before (p< 0.001). The cytokines also changed in the direction of no longer responding toward allergy. Median IL-17 decreased from 1.752 mg/dL to 0.417 mg/dL.
Conclusion: In patients with allergic rhinitis after specific sublingual desensitization treatment, IgE levels and cytokines such as IL-6 and IL-17 are significantly reduced and IgG, IgG4 and IgG1 levels are increased after treatment.
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References
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2. Passali D, Cingi C, Staffa P, Passali F, Muluk NB, Bellussi ML. The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. Asia Pacific Allergy. 2018; 8(1):e7. DOI: 10.5415/apallergy.2018.8.e7
3. Muluk NB, Bafaqeeh SA, Cingi C. Anti-IgE treatment in allergic rhinitis. International Journal of Pediatric Otorhinolaryngology. 2019; 127:109674. DOI: 10.1016/j.ijporl.2019.109674
4. Alamri RA, Aljabri GH, Tahlawi R, Aljabri HA, Aljabri SGH. Immunotherapy in the Treatment of Allergic Rhinitis in Children. Cureus. 2022; 14(12):e32464. DOI: 10.7759/cureus.32464
5. Gabet S, Rancière F, Just J, de Blic J, Lezmi G, Amat F, Momas I. Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children. World Allergy Organization Journal. 2019;12(9): 100057. DOI: 10.1016/j.waojou.2019.100057
6. Thuan HQ. Research on standardization of allergen Dermatophagoides Pteronyssinus and its application in the diagnosis and specific immunotherapy of allergic rhinitis [Ph.D thesis]. Hanoi: Vietnam Military Medical University; 2012. [access: 27/04/2012]. Available at: http://luanan.nlv.gov.vn/luanan?a=d&d=TTcFlGvGViZi2012.1.1
7. Smoldovskaya O, Feyzkhanova G, Voloshin S, Arefieva A, Chubarova A, Pavlushkina L, et al. Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases. World Allergy Organization Journal. 2018; 11:35. DOI: 10.1186/s40413-018-0220-5
8. Demš ar LA, Korošec P, Košnik M, Zidarn M, Rijavec M. Hymenoptera venom immunotherapy: immune mechanisms of induced protection and tolerance. Cells. 2021; 10(7):1575. DOI: 10.3390/cells10071575
9. Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. Journal of Allergy and Clinical Immunology. 2005; 116(3):608-13. DOI: 10.1016/j.jaci.2005.06.004
10. Queirós MG, Silva DA, Siman IL, Ynoue LH, Araújo NS, Pereira FL, et al. Modulation of mucosal/systemic antibody response after sublingual immunotherapy in mite-allergic children. Pediatric Allergy and Immunology. 2013; 24(8):752-61. DOI: 10.1111/pai.12163
11. Stylianou E, Ueland T, Borchsenius F, Michelsen AE, Øvstebø R, Eirik MT, et al. Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian journal of clinical and laboratory investigation. 2016; 76(2):118-27. DOI: 10.3109/00365513.2015.1110856
12. Scadding G. Cytokine profiles in allergic rhinitis. Current allergy and asthma reports. 2014; 14:1-8. DOI: 10.1007/s11882-014-0435-7
13. Hofmann MA, Fluhr JW, Ruwwe-Glösenkamp C, Stevanovic K, Bergmann KC, Zuberbier T. Role of IL-17 in atopy-A systematic review. Clinical and Translational Allergy. 2021; 11(6): e12047. DOI: 10.1002/clt2.12047
14. Qiu Q, Lu H, Lu C, Chen S, Han H. Variations in TGF-beta, IL-10, and IL-17 after specific immunotherapy and correlations with symptoms in patients with allergic rhinitis. Journal of investigational allergology & clinical immunology. 2012 [access: 01/10/2014]; 22(4):311-2. Available at: https://pubmed.ncbi.nlm.nih.gov/22812212/
15. Bachus H, McLaughlin E, Lewis C, Papillion AM, Benveniste EN, Hill DD, León B, et al. IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling. Cellular & Molecular Immunology. 2023; 1-15. DOI: 10.1038/s41423-023-01012-1
16. Goswami TK, Singh M, Dhawan M, Mitra S, Emran TB, Rabaan AA, Dhama K, et al. Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders-Advances and challenges. Human Vaccines & Immunotherapeutics. 2022; 18(1):2035117. DOI: 10.1080/21645515.2022.2035117
17. Wan Z, Zhou Z, Liu Y, Lai Y, Luo Y, Peng X, et al. Regulatory T cells and T helper 17 cells in viral infection. Scandinavian Journal of Immunology. 2020; 91(5):e12873. DOI: 10.1111/sji.12873
18. Gao S, Yu L, Zhang J, Li X, Zhou J, Zeng P, et al. Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis. Annals of Palliative Medicine. 2021; 10:4516-22. DOI: 10.21037/apm-21-546
19. Barberi S, Villa MP, Pajno GB, La Penna F, Barreto M, Cardelli P, et al. Immune response to sublingual immunotherapy in children allergic to mites. Journal of biological regulators and homeostatic agents. 2011 [access: 01/10/2011]; 25(4):627-34. Available at: https://europepmc.org/article/med/22217994
20. Bayrak DP, Aksun S, Altin Z, Bilgir F, Arslan IB, Colak H, et al. Allergic rhinitis and its relationship with IL-10, IL-17, TGF-ß, IFN-?, IL 22, and IL-35. Disease markers. 2018; 2018:1-6. DOI: 10.1155/2018/9131432
21. Song L, Luan B, Xu QR, Wang XF. Effect of TLR7 gene expression mediating NF-?B signaling pathway on the pathogenesis of bronchial asthma in mice and the intervention role of IFN-?. Eur Rev Med Pharmacol Sci. 2021; 25(2):866-79. DOI: 10.26355/eurrev_202101_24655
22. Xie S, Fan R, Tang Q, Cai X, Zhang H, Wang F, et al. Identification of robust biomarkers for early predicting efficacy of subcutaneous immunotherapy in children with house dust mite-induced allergic rhinitis by multiple cytokine profiling. Frontiers in Immunology. 2022; 12: 5866. DOI: 10.3389/fimmu.2021.805404
23. Liu X, Ng CL, De YW. The efficacy of sublingual immunotherapy for allergic diseases in Asia. Allergology International. 2018; 67(3):309-19. DOI: 10.1016/j.alit.2018.02.007
Published
2023-08-28
How to Cite
1.
Quan NT, Nghiem TD, Vu TM, Do HL, Nguyen CA. Changes in the levels of immunological markers after treatment in patients with allergic rhinitis. Rev Cubana Med Milit [Internet]. 2023 Aug. 28 [cited 2025 May 9];52(3):e02303127. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/3127
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