Platelet-rich fibrin and leukocytes in endoscopic endonasal approaches

Authors

Keywords:

cerebrospinal fluid leak, leukocyte and platelet rich fibrin, neuroendoscopy, skull base.

Abstract

Introduction: Regenerative medicine and cell therapy represents a safe and effective alternative in tissue regeneration. Fibrin rich in platelets and leukocytes promotes healing of the cranial base, with a significant decrease in complications, especially cerebrospinal fluid leak.
Objective: Describe the results of using fibrin rich in platelets and leukocytes as an accessory element in the repair of the cranial base.
Methods: A descriptive, cross-sectional study was carried out in 250 patients at the "Hermanos Ameijeiras" Hospital operated by endoscopic endonasal procedures with various tumors of the cranial base, in which fibrin rich in platelets and leukocytes was used during the reconstruction phase. An evaluation of the repair bar and the complications present was performed. For data analysis, absolute and relative frequencies were used as summary measures.
Results: 97.2 % of the repair barriers were classified as optimal. With the use of fibrin rich in platelets and leukocytes, 2.0 % of cerebrospinal fluid leak, 0.8 % of central nervous system infection, 4.0 % of postoperative nasal scabs are reported.
Conclusions: The present study evidences the positive effect of the use of leukocyte-platelet-rich fibrin in the repair of the skull cranial base, with great impact on the rate of cerebrospinal fluid leak and sinonasal quality of life.

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Author Biographies

Carlos Roberto Vargas Gálvez, Hospital Hermanos Ameijeiras. La Habana, Cuba.

Neurocirujano, servicio de Neurocirugía del hospital Clínico Quirúrgico Hermanos " Ameijeiras"

Omar López Arbolay, Hospital Hermanos Ameijeiras. La Habana, Cuba.

Neurocirujano, Doctor en Ciencias Médicas, servicio de Neurocirugía del hospital Clínico Quirúrgico Hermanos " Ameijeiras"

Marlon Manuel Ortiz Machín, Hospital Clínico Quirúrgico Hermanos "Ameijeiras"

Neurocirujano, Doctor en Ciencias Médicas, servicio de Neurocirugía del hospital Clínico Quirúrgico Hermanos " Ameijeiras"

Jesús Lázaro Diego de la Campa, Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Servicio de Hematología y banco de sangre. Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Mirian María Gómez Cardellá, Instituto de Hematología e Inmunología, La Habana, Cuba.

Servicio de Inmunohematología. Instituto de Hematología e Inmunología, La Habana, Cuba.

Irelys León Hernández, Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Servicio de Hematología y banco de sangre. Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Yaquelin Morales Novo, Hospital Hermanos Ameijeiras. La Habana, Cuba.

Servicio de Hematología y banco de sangre. Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Daymi Serpa Almaguer, Hospital Hermanos Ameijeiras. La Habana, Cuba.

Servicio de Hematología y banco de sangre. Hospital “Hermanos Ameijeiras”, La Habana, Cuba

Julio Antonio López Silva, Hospital Hermanos Ameijeiras. La Habana, Cuba.

Servicio de Hematología y banco de sangre. Hospital “Hermanos Ameijeiras”, La Habana, Cuba

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Published

2024-01-30

How to Cite

1.
Vargas Gálvez CR, López Arbolay O, Ortiz Machín MM, Diego de la Campa JL, Gómez Cardellá MM, León Hernández I, et al. Platelet-rich fibrin and leukocytes in endoscopic endonasal approaches. Rev Cubana Med Milit [Internet]. 2024 Jan. 30 [cited 2025 Apr. 4];53(1):e024014264. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/14264

Issue

Vol. 53 No. 1 (2024): January - March

Section

Brief Communication

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