Polymorphisms in genetic material damage repair genes and lung cancer

Authors

Keywords:

lung cancer, polymorphisms, repair genes, genetic susceptibility.

Abstract

Introduction: Lung cancer is one of the main health problems in Cuba and worldwide. Genetic differences due to single nucleotide polymorphisms are important factors involved in the genetic susceptibility to this disease. In Cuba, there are scarce data available on single nucleotide polymorphisms and their possible influence on the incidence and prognosis of cancer.
Objective: To expose the importance of the study of single nucleotide polymorphisms in DNA damage repair genes in lung cancer.
Results: Smoking is the main risk factor for developing lung cancer, however, approximately 15 % of smokers will develop the disease. Single nucleotide polymorphisms are important factors involved in genetic predisposition to diseases. The presence of polymorphic variants can modify the efficacy of repair systems, favoring the occurrence of genotoxicity and/or mutagenesis. They can also modify the response to oncological treatments and patient´s survival. Therefore, in addition to being susceptibility markers, polymorphisms are considered individual prognostic markers of response to therapy. This work emphasizes the usefulness of evaluating single nucleotide polymorphisms as clinical and susceptibility biomarkers in the Cuban population.
Conclusions: The study of single nucleotide polymorphisms will allow a personalized approach to oncological diseases, which could contribute to define groups of individuals at high risk of getting lung cancer, therefore, early disease detection.

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Author Biographies

Elizabeth Reyes Reyes, Instituto Nacional de Oncología y Radiobiología

Sección de Farmacología Clínica Experimental

Idania Rodeiro Guerra, Instituto de Ciencias del Mar

Departamento de Farmacología

José Alfredo Herrera Isidrón, Universidad de La Habana

Instituto de Ciencia y Tecnología de Materiales

Elizabeth Bárbara Cuétara Lugo, Instituto Nacional de Oncología y Radiobiología

Sección de Farmacología Clínica Experimental

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Published

2021-12-30

How to Cite

1.
Reyes Reyes E, Rodeiro Guerra I, Herrera Isidrón JA, Cuétara Lugo EB. Polymorphisms in genetic material damage repair genes and lung cancer. Rev Cubana Med Milit [Internet]. 2021 Dec. 30 [cited 2025 Mar. 31];51(1):e02201467. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/1467

Issue

Vol. 51 No. 1 (2022): January - March

Section

Review Article

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