Heberprot-P in the treatment of diabetic foot ulcers

Authors

Keywords:

amputation, diabetes mellitus, diabetic foot, skin transplantation, Heberprot-P.

Abstract

Introduction: The diabetic foot is one of the most feared complications of diabetes mellitus; It is the cause of 80 % of non-traumatic amputations worldwide. For decades, different treatments have been used to heal diabetic foot; growth factors have revolutionized this therapy. The participation of a multidisciplinary team with compliance with the action protocols and the use of Heberprot-P decrease the rate of amputations in patients with this condition.
Objective: To present the evolution of patients with diabetic foot ulcers, in different clinical stages, treated with Heberprot-P.
Development: Three clinical cases are presented; The first is a male patient, 56 years old, diabetic, with open transmetatarsal amputation in which 16 applications of Heberprot-P were performed and a skin graft was placed, the lesion closed in 45 days. The second is a 58-year-old patient, diabetic and hypertensive, with a right foot injury, with previous vascular surgery; 19 applications of Heberprot-P were performed and the lesion healed in 49 days. The third case is a 55-year-old patient, who was admitted due to an extensive injury to his right foot, 22 applications of Heberprot-P were performed, closure of the injury was achieved in 85 days and amputation was avoided.
Conclusions: The presented cases evolved favorably with Heberprot-P treatment.

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References

1. Berlanga JA, Mendoza YM, García AO et al. Epidermal Growth Factor (EGF) intralesional infiltration: From the bench to the diabetic ulcers cells. Integr Mol Med. 2019;6: [aprox. 20 p.]. DOI: 10.15761/IMM.1000354

2. Marinello J, Blanes JI, Escudero JR, Ibáñez V, Rodríguez J. Consenso sobre pie diabético. Angiología. 1997; 49(5):193-230.

3. International Diabetes Federation. IDF Diabetes Atlas. 2019. 10ma Edición. Brussels, Belgium: Inter Diab Fed; 2021. [acceso: 11/01/2022]. Disponible en: https://diabetesatlas.org/idfawp/resource-files/2021/07/IDF_Atlas_10th_Edition_2021.pdf

4. Somasundram P, Davashni P, Deepak S, Romashán P. Diabetes-related amputations in public health care sector in KwaZulu-Natal: a five-year perspective. Are we winning? Journal of Endocrinology, Metabolism and Diabetes of South Africa. 2019; 24(1):32-6. DOI: 10.1080/16089677.2018.1550956

5. Manickum P, Ramklass SS, Madiba TE. A five-year audit of lower limb amputations below the knee and rehabilitation outcomes: the Durban experience. Journal of Endocrinology Metabolism and Diabetes of South Africa. 2019; 24(2):41-45. DOI: 10.1080/16089677.2018.1553378

6. Escobar Amarales Y, Torres Romo UR, Escalante Padrón O, Fernández Franch N, Ibarra Viena V, Miranda Rodríguez E. El Heberprot-P® en el tratamiento de úlceras del pie diabético. AMC. 2014 [acceso: 11/01/2022]; 18(3):[aprox. 10 p]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552014000300005

7. Shojaie FA, Esmaelzadeh M, Larijani B. Assessment and treatment of diabetic foot ulcer. International Journal Clinical Practice. 2007; 61(11): 1931-38. DOI: 10.1111/j.1742-1241.2007.01534.x

8. Myers S, Navsaria H, Ojeh N. Skin engineering and keratinocyte stem cell therapy. En: Van Blitterswijk CA, De Boer J. Tissue Engineering. 2da ed. Academic Press; 2014: 497-528. DOI:10.1016/B978-0-12-420145-3.00015-8

9. Armstrong DG, Lavery LA, Harkless LB. Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation. Diabetes Care. 1998; 21(5):855-9. DOI: 10.2337/diacare.21.5.855

10. Ertugrul BM, Lipsky BA, Guvenc U. An Assessment of Intralesional Epidermal Growth Factor for Treating Diabetic Foot Wounds The First Experiences in Turkey. J Am Podiatr Med Assoc. 2017; 107(1):17-29. DOI: 10.7547/15-056

11. Berlanga JA, Fernández JI, López E, López AP. Heberprot-P: A novel product for treating advanced diabetic foot ulcer. MEDICC Review. 2013; 15(1): 11-5. DOI: 10.37757/MR2013V15.N1.4

12. Fernández-Montequín JI, Valenzuela-Silva CM, González Díaz O, Savigne W, Sancho Soutelo N, Rivero Fernández F, et al. Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled double-blind study. International Wound Journal. 2009; 6(6): 432-43. DOI: 10.1111/j.1742-481X.2009.00641.x

Published

2022-06-25

How to Cite

1.
Castillo Deprés S, Thabo Geoffrey M, Ledwaba L, K. Ngcobo T, Singh MMed N, Baldomero Hernández JE, et al. Heberprot-P in the treatment of diabetic foot ulcers. Rev Cubana Med Milit [Internet]. 2022 Jun. 25 [cited 2025 Apr. 4];51(3):e02201923. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/1923

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Section

Brief Communication