Brown tumors of maxillofacial region in patient with secondary hyperparathyroidism
Keywords:
neoplasms, secondary hyperparathyroidism, maxilla, mandible, renal dialysis.Abstract
Introduction: Brown tumors caused by hyperparathyroidism, primary or secondary, are lesions of the vascular soft intraosseous tissue that more frequently develop in long bones; occasionally, the lesions tend to be peripheral located on the alveolar ridges of the maxilla and mandible.Objective: To describe a case of a patient under hemodialysis treatment with brown tumors of the maxillofacial region due to secondary hyperparathyroidism.
Clinical case: We describe a 39-year-old male, he received hemodialysis for 20 years, for chronic renal failure with secondary hyperparathyroidism, and he comes by facial deformity in the image evaluation, there are osteolytic lesions in maxilla and mandible were suspected to be brown tumors.
Conclusions: This manifestation of secondary hyperparathyroidism can be expected to occur with increased longevity of patients with renal failure. A complete evaluation can help to reach a correct diagnosis.
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References
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2. Suarez-Cunqueiro MM, Schoen R, Kersten A, Klisch J, Schmelzeisen R. Brown tumor of the mandible as first manifestation of atypical parathyroid adenoma. J Oral Maxillofac Surg. 2004; 62(8):1024–8. DOI: 10.1016/j.joms.2004.02.011
3. Ramos B, Pinero A, Illana J, Palazón T, Méndez S, Parrilla Paricio P. Tumor pardo maxilar como primera manifestación del hiperparatiroidismo primario. Cir Esp. 2001; 69(5):498–500. DOI: 10.1016/S0009-739X(01)71790-3
4. Gallana Álvarez S, Salazar Fernández CI, Avellá Vecino FJ, Torres Gómez J, Pérez Sánchez JM. Tumor pardo maxilar: elemento diagnóstico de hiperparatiroidismo primario. Rev Esp Cir Oral Maxilofac. 2015 [acceso: 04/04/2022]; 27(4):225–30. Disponible en: https://scielo.isciii.es/pdf/maxi/v27n4/en_caso2.pdf
5. Mirra JM. Bone Tumor. Clinical, Radiologic, and Pathologic Correlations. Philadelphia: PA, Lea & Febiger; 1989.
6. Gleason BC, Kleinman PK, Debelenko LV, Rahbar R, Gebhardt MC, Pérez- Atayde AR. Novel karyotypes in giant cell-rich lesions of bone. Am J Surg Pathol. 2007; 31(6):926-32. DOI: 10.1097/PAS.0b013e31802fb498
7. Chavin HC, Pisarevsky AA, Chavin C. Brown tumor as the initial manifestation of primary hyperparathyroidism. Medicine. 2008 [acceso: 04/04/2022]; 68(3):219-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18689153/
8. Angadi PV, Rekha K, Shetty SR. An exophytic mandibular brown tumor: an unusual presentation of primary hyperparathyroidism. Oral Maxillofac Surg. 2010; 14(1):67-9. DOI: 10.1007/s10006-009-0186-0
9. Sumer AP, Arik N, Sumer M, Karagoz F. A rare complication of secondary hyperparathyroidism. Brown tumor of the maxilla and mandible. Saudi Med J. 2004 [acceso: 04/04/2022]; 25(12):2010-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15711688/
10. Yamazaky H, Ota Y, Aoki T, Karakida K. Brown tumor of the maxilla and mandible: progressive mandibular brown tumor after removal of parathyroid adenoma. J Oral Maxillofac Surg. 2003; 61(6):719-22. DOI: 10.1053/joms.2003.50142
11. Kar DK, Gupta SK, Agarwal A, Mishra SK. Brown tumor of the palate and mandible in association with primary hyperparathyroidism. J Oral Maxillofac Surg. 2001; 59(11):1352-4. DOI: 10.1053/joms.2001.27533
12. Agarwal G, Mishra SK, Kar DK, Singh AK, Arya V, Gupta SK, et al. Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. Surgery. 2002;132(6):1075-85. DOI: 10.1067/msy.2002.128484
13. Lessa MM, Sakae FA, Tsuji RK, Aráujo BC, Voegels RL, Butugan O. Brown tumor of the facial bones: case report and literature review. Ear Nose Throat J. 2005 [acceso: 04/04/2022]; 84(7):432-4. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/014556130508400714
2. Suarez-Cunqueiro MM, Schoen R, Kersten A, Klisch J, Schmelzeisen R. Brown tumor of the mandible as first manifestation of atypical parathyroid adenoma. J Oral Maxillofac Surg. 2004; 62(8):1024–8. DOI: 10.1016/j.joms.2004.02.011
3. Ramos B, Pinero A, Illana J, Palazón T, Méndez S, Parrilla Paricio P. Tumor pardo maxilar como primera manifestación del hiperparatiroidismo primario. Cir Esp. 2001; 69(5):498–500. DOI: 10.1016/S0009-739X(01)71790-3
4. Gallana Álvarez S, Salazar Fernández CI, Avellá Vecino FJ, Torres Gómez J, Pérez Sánchez JM. Tumor pardo maxilar: elemento diagnóstico de hiperparatiroidismo primario. Rev Esp Cir Oral Maxilofac. 2015 [acceso: 04/04/2022]; 27(4):225–30. Disponible en: https://scielo.isciii.es/pdf/maxi/v27n4/en_caso2.pdf
5. Mirra JM. Bone Tumor. Clinical, Radiologic, and Pathologic Correlations. Philadelphia: PA, Lea & Febiger; 1989.
6. Gleason BC, Kleinman PK, Debelenko LV, Rahbar R, Gebhardt MC, Pérez- Atayde AR. Novel karyotypes in giant cell-rich lesions of bone. Am J Surg Pathol. 2007; 31(6):926-32. DOI: 10.1097/PAS.0b013e31802fb498
7. Chavin HC, Pisarevsky AA, Chavin C. Brown tumor as the initial manifestation of primary hyperparathyroidism. Medicine. 2008 [acceso: 04/04/2022]; 68(3):219-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18689153/
8. Angadi PV, Rekha K, Shetty SR. An exophytic mandibular brown tumor: an unusual presentation of primary hyperparathyroidism. Oral Maxillofac Surg. 2010; 14(1):67-9. DOI: 10.1007/s10006-009-0186-0
9. Sumer AP, Arik N, Sumer M, Karagoz F. A rare complication of secondary hyperparathyroidism. Brown tumor of the maxilla and mandible. Saudi Med J. 2004 [acceso: 04/04/2022]; 25(12):2010-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15711688/
10. Yamazaky H, Ota Y, Aoki T, Karakida K. Brown tumor of the maxilla and mandible: progressive mandibular brown tumor after removal of parathyroid adenoma. J Oral Maxillofac Surg. 2003; 61(6):719-22. DOI: 10.1053/joms.2003.50142
11. Kar DK, Gupta SK, Agarwal A, Mishra SK. Brown tumor of the palate and mandible in association with primary hyperparathyroidism. J Oral Maxillofac Surg. 2001; 59(11):1352-4. DOI: 10.1053/joms.2001.27533
12. Agarwal G, Mishra SK, Kar DK, Singh AK, Arya V, Gupta SK, et al. Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy. Surgery. 2002;132(6):1075-85. DOI: 10.1067/msy.2002.128484
13. Lessa MM, Sakae FA, Tsuji RK, Aráujo BC, Voegels RL, Butugan O. Brown tumor of the facial bones: case report and literature review. Ear Nose Throat J. 2005 [acceso: 04/04/2022]; 84(7):432-4. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/014556130508400714
Published
2022-07-28
How to Cite
1.
Deronceré-Columbié Y, Cedeño-Ramos D. Brown tumors of maxillofacial region in patient with secondary hyperparathyroidism. Rev Cubana Med Milit [Internet]. 2022 Jul. 28 [cited 2025 May 14];51(4):e02202033. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2033
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