Autoantibodies and histocompatibility system in patients diagnosed with rheumatoid arthritis

Authors

Keywords:

rheumatoid arthritis, antibodies, genetics, immunity.

Abstract

Introduction: Rheumatoid arthritis is described as an autoimmune disease in which there is a genetic pattern with alterations in the histocompatibility system; HLA DR4 being the pattern that is most frequently reported in this disease.
Objective: To identify the relationship between genetic alterations and seropositivity in patients diagnosed with rheumatoid arthritis.
Methods: Observational, cross-sectional and descriptive research with a universe of 157 patients diagnosed with rheumatoid arthritis, of which 113 were part of the research sample. The presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies was determined, and a genetic study was performed to identify the presence of HLA-DR3 and HLA-DR4. The non-parametric Pearson correlation test was used to determine the correlation between the genetic pattern and seropositivity.
Results: Average age of 58.74 years with a predominance of female patients (72.57 %); 38.05 % presented at least one associated comorbidity. Rheumatoid factor was positive in 60.18 % of the patients, while positive anti-cyclic citrullinated peptide was identified in 41.59 % of the cases studied. Genetic pattern alterations were identified in 66.37 % of the patients; HLA DR4 was present independently in 38.67 % of the positive cases and combined with HLA DR3 in 20.66 %.
Conclusion: A significant positive correlation was identified between alterations in the genetic pattern and seropositivity. The presence of genetic pattern alterations triples the risk of seropositivity in patients with rheumatoid arthritis.

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Author Biographies

Urbano Solis Cartas, Universidad Nacional de Chimborazo Escuela Superior Politécnica de Chimborazo

Especialista en Reumatología

Jorge Luis Valdés González, Escuela Superior Politécnica de Chimborazo

Especialista en Dermatología

References

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Published

2022-08-16

How to Cite

1.
Solis Cartas U, Valdés González JL. Autoantibodies and histocompatibility system in patients diagnosed with rheumatoid arthritis. Rev Cubana Med Milit [Internet]. 2022 Aug. 16 [cited 2025 Apr. 3];51(3):e02202059. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2059

Issue

Vol. 51 No. 3 (2022): July - September

Section

Research Article

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