Variation of oxygen saturation in the detection of pulmonary hypertension

Authors

Keywords:

echocardiography, pulmonary arterial hypertension, oxygen, 6-Minute Walk Test.

Abstract

Introduction: The analysis of oxygen saturation during the 6-minute walk can represent a useful, accessible and reproducible tool for the assessment of patients with pulmonary arterial hypertension.
Objective: To establish the validity of the variation in oxygen saturation in the 6-minute walk for the diagnosis of pulmonary hypertension by transthoracic echocardiography.
Methods: Cross-sectional study in patients with suspected pulmonary hypertension who underwent a 6-minute walk and transthoracic echocardiography. The validity and correlation of the variation of the oxygen saturation obtained from the 6-minute walk and the systolic pressure values of the pulmonary artery by echocardiography were calculated.
Results: The average age of the subjects was 70.8 years (+/-: 13.3), 52.5% of the people were men. It will be eliminated that the mean initial oxygen saturation in patients with and without probable pulmonary hypertension was similar, with 89.9% (+/-: 4.4) vs 89.4% (+/-: 4.6), respectively. The correlation coefficient between the decrease in oxygen saturation and the systolic pressure of the pulmonary artery was 0.11.
Conclusion: The variation in oxygen saturation during the 6-minute walk has an acceptable sensitivity for the detection of probable pulmonary hypertension in transthoracic echocardiography. The drop in oxygen saturation would be an alternative to consider suspecting pulmonary hypertension.

Downloads

Download data is not yet available.

Author Biographies

Alirio Bastidas Goyes, Universidad de La Sabana

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Barbarita Mantilla Cardozo, Universidad de La Sabana

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Gustavo Adolfo Hincapié Díaz, Hospital Militar Central

Universidad Militar Nueva Granada. Bogotá, Colombia.

Eduardo Tuta Quintero, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Juan Sebastián Mancera, Universidad Militar Nueva Granada. Bogotá, Colombia.

Universidad Militar Nueva Granada. Bogotá, Colombia.

Andrés Fernando Pereira, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Tatiana Vargas, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Abraham José Brito Rodríguez, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Stefania Forero Caldas, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Cristian Camilo López, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

Daniel Mateo Prieto, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

José Ignacio Nuñez, Universidad de La Sabana. Bogotá, Colombia

Facultad de Medicina, Universidad de La Sabana. Bogotá, Colombia

References

1. Bisserier M, Pradhan N, Hadri L. Current and emerging therapeutic approaches to pulmonary hypertension. Rev Cardiovasc Med. 2020; 21(2):163-79. DOI: 10.31083/j.rcm.2020.02.597

2. Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018; 360:j5492. DOI: 10.1136/bmj.j5492

3. Agarwala P, Salzman SH. Six-Minute Walk Test: Clinical Role, Technique, Coding, and Reimbursement. Chest. 2020; 157(3):603-11. DOI: 10.1016/j.chest.2019.10.014

4. Mandras SA, Mehta HS, Vaidya A. Pulmonary Hypertension: A Brief Guide for Clinicians. Mayo Clin Proc. 2020; 95(9):1978-88. DOI: 10.1016/j.mayocp.2020.04.039

5. Demir R, Küçükoğlu MS. Six-minute walk test in pulmonary arterial hypertension. Anatol J Cardiol. 2015; 15(3):249-54. DOI: 10.5152/akd.2015.5834

6. Badesch DB, Abman SH, Simonneau G, Rubin LJ, McLaughlin V V. Medical therapy for pulmonary arterial hypertension: Updated ACCP evidence-based clinical practice guidelines. Chest. 2007; 131(6):1917-28. DOI: 10.1378/chest.06-2674

7. Bisserier M, Pradhan N, Hadri L. Current and emerging therapeutic approaches to pulmonary hypertension. Rev Cardiovasc Med. 2020; 21(2):163-79. DOI: 10.31083/j.rcm.2020.02.597

8. Mansour A, Roushdy A, Harb B, Attia H. Non-invasive Predictors of Functional Capacity in Patients with Pulmonary Hypertension due to Congenital Heart Disease: A Pilot Echocardiography Single-Center Study. J Cardiovasc Echogr. 2020; 30(4):193-200. DOI: 10.4103/jcecho.jcecho_41_20

9. Küçükoğlu MS, Hanta İ, Akdeniz B, Güllülü S, Atahan E, Sayın T, et al. Clinical efficacy, safety, tolerability, and survival outcome of long-term inhaled iloprost treatment in the management of pulmonary arterial hypertension: Data from prospective multicenter observational OPTION study. Anatol J Cardiol. 2021; 25(10):721-32. DOI: 10.5152/AnatolJCardiol.2021.03009

10. González NF, Anchique C V. Test de caminata de 6 minutos en pacientes de rehabilitación cardiaca de altitud moderada. Rev Colomb Cardiol. 2017; 30(2):1-7. DOI: 10.1016/j.rccar.2017.01.004

11. Bastidas A, Tuta E, Hincapié E, Santiago E, Gutiérrez C, Echeverría C, et al. Correlación y concordancia entre el valor de metros caminados durante la caminata de seis minutos realizada en corredor y banda estática no motorizada. Gac Méd Caracas 2021;129(3):553-61. DOI: 10.47307/GMC.2021.129.3.4

12. Alhirsan SM, Capó-Lugo CE, Brown DA. Effects of different types of augmented feedback on intrinsic motivation and walking speed performance in post-stroke: A study protocol. Contemp Clin Trials Commun. 2021; 24:100-863. DOI: 10.1016/j.conctc.2021.100863

13. Nakahara Y, Taniguchi H, Kimura T, Kondoh Y, Arizono S, Nishimura K, et al. Exercise hypoxaemia as a predictor of pulmonary hypertension in COPD patients without severe resting hypoxaemia. Respirology. 2017; 22(1):120-5. DOI: 10.1111/resp.12863

14. Andrianopoulos V, Franssen FM, Peeters JP, Ubachs TJ, Bukari H, Groenen M, et al. Exercise-induced oxygen desaturation in COPD patients without resting hypoxemia. Respir Physiol Neurobiol. 2014; 190:40-6. DOI: 10.1016/j.resp.2013.10.002

15. Oki Y, Kaneko M, Fujimoto Y, Sakai H, Misu S, Mitani Y, et al. Usefulness of the 6-minute walk test as a screening test for pulmonary arterial enlargement in COPD. Int J Chron Obstruct Pulmon Dis. 2016; 11:2869-75. DOI: 10.2147/COPD.S114497

16. Fujimoto Y, Oki Y, Kaneko M, Sakai H, Misu S, Yamaguchi T, et al. Usefulness of the desaturation-distance ratio from a six-minute walk test for patients with COPD. Int J Chron Obstruct Pulmon Dis. 2017; 12:2669-75. DOI: 10.2147/COPD.S143477

17. Hage JJ, Brinkman RJ. Andreas Vesalius' understanding of pulmonary ventilation. Respir Physiol Neurobiol. 2016; 231:37-44. DOI: 10.1016/j.resp.2016.05.015

18. Stoffels AAF, van den Borst B, Peters JB, Klaassen MPM, van Helvoort HAC, Meys R, et al; BASES consortium. Correlates of variability in endurance shuttle walk test time in patients with chronic obstructive pulmonary disease. PLoSOne. 2021; 16(4):e0249786. DOI: 10.1371/journal.pone.0249786

19. Vogiatzis I, Zakynthinos G, Andrianopoulos V. Mechanisms of physical activity limitation in chronic lung diseases. Pulm Med. 2012; 2012:634-761. DOI: 10.1155/2012/634761

20. Vonk Noordegraaf A, Chin KM, Haddad F, Hassoun PM, Hemnes AR, Hopkins SR, et al. Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: anupdate. Eur Respir J. 2019; 53(1):1801900. DOI: 10.1183/13993003.01900-2018

21. ATS Committee On Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166(1):111-7. DOI: 10.1164/ajrccm.166.1.at1102

22. Bastidas-Goyes A, Hincapié-Díaz G, Tuta-Quintero E, Rodríguez-Rojas S. Analysis of lung function in a Colombian military with a medical history of thoracic trauma. Rev Med Hosp Gen Mex. 2021; 84(3): 110-15. DOI: 10.24875/HGMX.21000005

23. Duncan MS, Alcorn CW, Freiberg MS, So-Armah K, Patterson OV, DuVall SL, et al. Association Between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study. Lancet Healthy Longev. 2021; 2(7):e417-e425. DOI: 10.1016/s2666-7568(21)00116-1

24. Maron BA, Choudhary G, Khan UA, Jankowich MD, McChesney H, Ferrazzani SJ, et al. Clinical Profile and underdiagnosis of pulmonary hypertension in US veteran patients. Circ Heart Fail. 2013; 6(5):906-12. DOI: 10.1161/CIRCHEARTFAILURE.112.000091

Published

2022-10-17

How to Cite

1.
Bastidas Goyes A, Mantilla Cardozo B, Hincapié Díaz GA, Tuta Quintero E, Mancera JS, Pereira AF, et al. Variation of oxygen saturation in the detection of pulmonary hypertension. Rev Cubana Med Milit [Internet]. 2022 Oct. 17 [cited 2025 Apr. 2];51(4):e02202107. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2107

Issue

Section

Research Article