Treatment of COVID-19 patients with the antibody itolizumab (anti-CD6)

Authors

Keywords:

COVID-19, SARS-CoV-2, Cytokine Release Syndrome, Activated-Leukocyte Cell Adhesion Molecule.

Abstract

Treatment of COVID-19 patients with the antibody itolizumab (anti-CD6)

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Author Biographies

Tatiana Hernández Casola, Hospital Roberto Rodríguez Fernández.

Departamento de Ensayos Clínicos. Coordinadora de Investigación Clínica.

Rodolfo Vega Candelario, Hospital Roberto Rodríguez Fernández.

Servicio de Cardiologia.

References

1. Roshni Menon, Brinda G David. Itolizumab - a humanized anti-CD6 monoclonal antibody with a better side effects profile for the treatment of psoriasis. Clinical, Cosmetic and Investigational Dermatology. Pondicherry, India. 2015 [acceso: 20/03/2019]; 8:215-22. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC440773

2. Lippi G, Sanchis-Gomar F, Henry BM. COVID-19: unravelling the clinical progression of nature's virtually perfect biological wea-pon. Ann Transl Med. 2020;8(11):693. DOI: 10.21037/atm-20-3989.

3. Gore V, Kshirsagar DP, Bhat SM. Itolizumab treatment for cytokine release syndrome in moderate to severe acute respiratory distress syndrome due to COVID-19: clinical outcomes, a retrospective study. J Assoc Physicians India. 2021; 69:43-48. DOI: 10. covidwho-1161613

4. Thacker HP, Halnor D, Dhekane A, Wadhwa N, Patil S, Gandhi B, et al. An early experience of Itolizumab with best supportive care in the treatment of moderate to severe COVID-19 patients: A retrospective study. IP Indian J Immunol Respir Med.2021; 6(1):24-8. DOI: 10.18231/j.ijirm.2021.005

5. Atal S, Fatima Z. IL-6 inhibitors in the treatment of serious COVID-19: a promising therapy? Pharmaceut Med. 2020; 34:223-31. DOI: 10.1007/s40290-020-00342-z

6. Chen X, Zhao B, Qu Y.Detectable serum severe acute respiratory syndrome coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in critically ill patients with coronavirus disease 2019. Clin. Infect. Dis.2020; 71(8):1937-42. DOI: 10.1093/cid/ciaa449

7. Gubernatorova EO, Gorshkova EA, Polinova AI, Drutskaya MS. IL-6: relevance for immunopathology of SARS-CoV-2. Cytokine Growth Factor Rev. 2020; 53:13-24. DOI: 10.1016/j.cytogfr.2020.05.009

8. Steeland S, Libert C, Vandenbroucke RE. A new venue of TNF targeting. Int J Mol Sci 2018; 19:1442. DOI: 10.1016/j.cytogfr.2020.05.009

9. Stone JH, Frigault MJ, Serling-Boyd NJ. Efficacy of tocilizumab in patients hospitalized with covid-19. N Engl J Med. 2020; 383(24):2333-44. DOI: 10.1056/NEJMoa2028836

Published

2023-07-24

How to Cite

1.
Casola TH, Candelario RV. Treatment of COVID-19 patients with the antibody itolizumab (anti-CD6). Rev Cubana Med Milit [Internet]. 2023 Jul. 24 [cited 2025 May 9];52(3):e02302609. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2609

Issue

Section

Letter to the Editor