DRESS syndrome associated to the use of anticonvulsant medications
Keywords:
fever, eosinophilia, exanthema, anticonvulsant.Abstract
Introduction: Drug Reaction with Eosinophilia and Systemic Symptoms - DRESS, syndrome constitutes a serious adverse reaction to medications, mainly anticonvulsant drugs.Objective: To describe the clinical evolution of DRESS syndrome in a patient treated at the Hospital Militar Central "Dr. Luis Díaz Soto".
Case Report: 27-year-old female patient with a personal pathological history of epilepsy. Three months after initiation of diphenylhydantoin therapy, fever appeared maculopapular rash that progressed to exfoliative erythroderma, signs of liver damage, cervical adenopathies and eosinophilia. DRESS syndrome was diagnosed secondary to the use of anticonvulsants.
Conclusions: The clinical evolution was favorable, after the withdrawal of the drug and the application of steroids orally.
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References
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12. Chamorro NA, Avalos ME, Mabel VL. Síndrome de DRESS y Necrólisis Epidérmica Tóxica por el uso de lamotrigina: a propósito de dos casos. Rev Pediatr. 2014[acceso: 10/05/2019]; 41(2):131-138. Disponible en: https://scielo.iics.una.py/scielo.php?script=sci_abstract&pid=S168-398032014000200006&lng=en&nrm=iso&tlng=es
2. Rosenbaum J, Alex G, Roberts H. Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine. J Paediatr Child Health. 2010[acceso: 26/07/2019]; 46(4):193-6. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1754.2009.01660.x
3. Walsh S, Creamer D. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update review of current thinking. Clinical and Experimental Dermatology. 2011[acceso: 26/07/2019]; 36(1):6-11. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2230.2010.03967.x
4. Fernández de Córdova-Rodríguez LR, Guzmán Guillén KA, Fernández de Córdova-Aguirre JC. Síndrome DRESS o reacción a fármacos con eosinofilia y síntomas sistémicos asociada con el consumo de fármacos antituberculosos. Revista Alergia México. 2015[acceso: 24/07/2019]; 62(2):149-56. Disponible en: https://eds.a.ebscohost.com/eds/detail/detail?vid=0&sid=1647ea74-f974-4077-85f1-616e739f7a89%40sessionmgr4007&bdata=Jmxhbmc9ZXMmc2l0ZT1lZHM-tbGl2ZQ%3d%3d
5. Osuna Osuna J, Toledo Bahena ME, Valencia Herrera A, Ramírez Cortés E, Mena Cedillos C. Reacción por drogas con eosinofilia: Síndrome DRESS, un gran simulador. Dermatología CMQ. 2013[acceso: 16/06/2019]; 11(2):142-7. Disponible en: https://www.medigraphic.com/pdfs/cosmetica/dcm-2013/dcm132m.pdf
6. Cacoub P, Mussette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS Syndrome: A Literature Review. The Am J Med. 2011[acceso: 16/06/2019]; 124(7):588-597. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/21592453
7. Ghannam M, Mansour S, Nabulsi A. Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature. ClinMol Allergy. 2017[acceso: 10/05/2019];15(14):[aprox. 15 p.]. Disponible en: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-017-0069-0
8. Wang F, Li Y, Mo Y, Shen C, Yang L, Zhang X. Cutaneous adverse drug reactions: an 8-year retrospective study on hospitalized patients in Southern China. Indian J Dermatol Venereol Leprol. 2012[acceso: 16/06/2019];78(4):488-90. Disponible en: https://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=4;spage=488;epage=490;aulast=Wang
9. Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B, et al. A 6-month prospective survey of cutaneous drug reactions in a hospital setting. Br J Dermatol. 2003[acceso: 10/05/2019];149(5):1018-22. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/j.13652133.2003.0558-4.x?sid=nlm%3Apubmed
10. Graña D, Botta C, Núñez M.Síndrome de dress. A propósito de tres casos clínicos y revisión de la literatura. Rev Med Int. 2015[acceso: 10/05/2019]; 37(2):68-73. Disponible en: https://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S168-8423X2015000200004
11. Ramos L. Síndrome Dress. Presentación de un caso y actualización. Rev. Argent. Dermatol. 2013[acceso: 10/05/2019]; 94(3):[aprox. 12 p.]. Disponible en: https://rad-online.org.ar/2013/10/01/sindrome-dress-presentacion-de-un-caso-y-actualizacion.
12. Chamorro NA, Avalos ME, Mabel VL. Síndrome de DRESS y Necrólisis Epidérmica Tóxica por el uso de lamotrigina: a propósito de dos casos. Rev Pediatr. 2014[acceso: 10/05/2019]; 41(2):131-138. Disponible en: https://scielo.iics.una.py/scielo.php?script=sci_abstract&pid=S168-398032014000200006&lng=en&nrm=iso&tlng=es
Published
2020-08-02
How to Cite
1.
Belaunde Clausell A, Pacheco Otero Y, Peña Ruiz RM. DRESS syndrome associated to the use of anticonvulsant medications. Rev Cubana Med Milit [Internet]. 2020 Aug. 2 [cited 2025 Apr. 3];49(3):e0200461. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/461
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