Caracterización clínica epidemiológica de pacientes con EPOC y cáncer de pulmón

Authors

  • Ernesto Ramírez Ramírez Hospital Militar Dr. Joaquin Castillo Duany
  • Dennis Sánchez Ramos Hospital Militar Dr. Joaquin Castillo Duany
  • Jorge Alberto Castañeda Fernández Hospital Militar Dr. Joaquin Castillo Duany
  • Edgar Benítez Sánchez Hospital Militar Dr. Joaquin Castillo Duany
  • Armando Ernesto Pérez Cala

Abstract

Introducción: el cáncer de pulmón es la neoplasia más frecuente y la primera causa de muerte por cáncer actualmente.
Objetivo: caracterizar clínica y epidemiológicamente a pacientes fumadores con EPOC y cáncer de pulmón no microcítico.
Método: estudio observacional, retrospectivo, transversal a pacientes egresados con diagnóstico de cáncer de pulmón y portadores de EPOC, durante el periodo comprendido entre enero de 2009 y enero de 2015. De 112 individuos fueron seleccionados 55 pacientes. Fueron analizadas variables sociodemográficas, intensidad del tabaquismo y del efecto acumulativo del tabaco. Además de las medidas de resumen se empleó análisis de varianzas para establecer la correlación lineal entre tabaquismo, EPOC y cáncer de pulmón.
Resultados: la mayoría de los pacientes con cáncer de pulmón y EPOC pertenecían al sexo femenino (85,7 %) y el 75 % de los que portaban ambas afecciones se encontraba en grupos de edades menores de los 60 años. La edad de iniciación temprana del hábito, tiempo fumando, y número de paquetes de cigarrillos consumidos al año, fueron las variables que mostraron una asociación más significativa con ambas entidades (p= 0,01; 0,00; y 0,02 respectivamente).
Conclusiones: la coexistencia de EPOC y cáncer de pulmón resultó más frecuente en el sexo femenino y en edades inferiores a los 60 años. Hubo mayor representación en pacientes con mayor intensidad del tabaquismo. Existió correlación entre el efecto acumulativo del tabaquismo y las probabilidades de desarrollar EPOC y cáncer en fumadores, en especial con los de mayor tiempo de consumo y los que fuman mayor número de paquetes al año.

Downloads

Download data is not yet available.

Author Biography

Edgar Benítez Sánchez, Hospital Militar Dr. Joaquin Castillo Duany

Jefe Sección Ciencia e Innovacion Tecnológica

References

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, ParkinDM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015 Mar 1;136(5):E359-86.

2. Siegel R, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017; 67(1):7-30.

3. Torre LA, Siegel RL,Ward EM,Jemal A. Global Cancer Incidence and Mortality Rates and Trends-An Update. Cancer Epidemiol Biomarkers Prev. 2016 Jan-Dec[Cited 2017 Oct 10];25(1):117-26. Availalble from: http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=26667886.

4. Hall F. Reverse translational implications of genome-wide association studies for addiction genetics. In: Preedy V. (Ed.), the Neuropathology of Drug Additions and Drug Misuse. London: Elsevier; 2016. P. 53-60.

5. SanchezSalcedo P, Willson DO, deTorres JP, Wessfeld JC, Berto J, Campo A, et al. Improving selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med. 2015[Cited 2017 Oct 10];191(8):924-31.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447319/.

6. Oken MM, Hochking WG, Kvale PA, Andriole GL, Buys SS, Church TR, et al. Screening by chest radiograph and lung cancer mortality: The Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA 2011[Cited 2017 Oct 10];306(17):1865-73.Availalble from: https://jamanetwork.com/journals/jama/fullarticle/1104579.

7. Van der Aalst LM, ten Haaf K, de Koning HJ. Lung cancer screening: Latest developments and unanswered questions. Lancet Respir Med. 2016;4(9):749-61.

8. Li K, Husing A, Sookthai D, Bergmann M, Boeing H, Becker N, et al. Selecting high-risk individuals for lung cancer screening: a prospective evaluation of existing risk models and eligibility criteria in German EPIC cohort. Cancer Prev Res (Phila) 2015;8(9):777-85.Dsiponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673786/.

9. Humphrey LL, Deffebach M, Pappas M, Baumann C, Artis K, Mitchell JP, Zakher B, Fu R, Slatore CG. Screening for lung cancer with low-dose computed tomography: a systematic review to update the US Preventive services task force recommendation. Ann Intern Med 2013[Cited 2017 Oct 10];159:411-20.Availalble from: https://www.ncbi.nlm.nih.gov/books/NBK154610/.

10. Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB. Screening for lung cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2013[Cited 2017 Oct 10];143:e78S-92S. Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749713/.

11. Petty TL. Are COPD and lung cancer two manifestations of the same disease? Chest 2005; 128(4):1895-98.

12. Niewoehner DE. Clinical practice: outpatient management of severe COPD. N Engl J Med. 2010;362:1407-16.

13. Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Roelan JH,et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016 Jul;66(4):271-89.

14. Kiyohara C, Ohno Y. Sex differences in lung cancer susceptibility: a review. Gend Med. 2010 Oct;7(5):381-401.

15. De Matteis S, Consonni D, Pesatori AC, Bergen AW, Bertazzi PA, Caporaso NE, et al. Are women who smoke at higher risk for lung cancer than men who smoke? Am J Epidemiol. 2013;177(7):601-12.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657535/.

16. Powell HA, Iyen-Omofoman B, Hubbard RB, Baldwin DR, Tata LJ. The association between smoking quantity and lung cancer in men and women. Chest. 2013;143:123-9.

17. North CM, Christiani DC. Women and Lung Cancer: What's New? Semin Thorac Cardiovasc Surg. 2014;25(2):1-13.

18. Durham AL, Adcock IM. The relationship between COPD and lung cancer. Lung Can. 2015;90:121-7.

19. Punturieri A, Szabo E, Croxton TL, Shapiro SD, Dubinett SM. Lung cancer and chronic obstructive pulmonary disease: Needs and opportunities for integrated research. J Natl Cancer Inst 2009;101:554-9.

20. Sekine Y, Katsura H, Koh E, Hiroshima K, Fujisawa T. Early detection of COPD is important for lung cancer surveillance. Eur Respir J 2012 May;39(5):1230-40.

21. Chen LS, Hung RJ, Baker T. CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis-a meta-analysis. J. Natl. Cancer Inst. 2015[Cited 2017 Oct 10];107(5):88-93.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822525/.

22. Bergen AW, Javitz HS, Krasnow R. Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenet. Genomics. 2013;23(2):94-103.

23. Campbell JD, Alexandrov A, Kim J, Wala J, Berger AH, Pedanallu CS,et al.Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 2016[Cited 2017 Oct 10];48(6):607-16.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884143/.

24. Adcock I, Caramori G, Barnes P. Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respir 2011;81(4):19.

25. Young RP, Hopkins RJ. Link between COPD and lung cancer, Respir. Med 2010[Cited 2017 Oct 10]; 104(5):758-9.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718929/.

26. Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2015;378(9795):1015-26.

27. Papadopuolos A, Guida F, Leffondré K, Cénée F, Cyr D, Schmaus A, et al. Heavy smoking and lung cancer: Are women at higher risk? Result of the ICARE study. Br J Cancer. 2014 Mar 4;110(5):1385-91.

28. Sprouffske K, Pepper J W, Maley CC. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prev Res (Phila). 2011 Jul;4(7):1135-44.

29. Jia P, Pao W, Zhao Z. Patterns and processes of somatic mutations in nine major cancers. BMC Med Genomics, 2014 Feb 19;7:11.

30. Liggett LA, De Gregori J. Changing mutational and adaptive landscapes and the genesis of cancer. Biochim Biophys Acta. 2017 Apr 1867(2):84-94.

31. Rozhot A, De Gregori J. The evolution of lifespan and age-dependent cancer risk. Trends in cancer, 2016 Oct[Cited 2017 Oct 10];2(10):552-60.Availalble from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400291/.

32. De Gregori J. Challenging the axiom: Does the occurrence of oncogenic mutations truly limit cancer development with age. Oncogene, July 2012;1-7.

Downloads

Published

2017-11-23

How to Cite

1.
Ramírez Ramírez E, Sánchez Ramos D, Castañeda Fernández JA, Benítez Sánchez E, Pérez Cala AE. Caracterización clínica epidemiológica de pacientes con EPOC y cáncer de pulmón. Rev Cubana Med Milit [Internet]. 2017 Nov. 23 [cited 2025 Jan. 9];46(4). Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/53

Issue

Vol. 46 No. 4 (2017): Octubre-Diciembre

Section

Research Article

License

Authors who have publications with this Journal accept the following terms:

  • The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
  • The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
  • Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.

Most read articles by the same author(s)