Relationship of CagA/VacA genotypes of Helicobacter pylori with precursor lesions of gastric cancer
Keywords:
Helicobacter pylori, CagA, VacA, gastric atrophy.Abstract
Introduction: Helicobacter pylori predisposes to gastric cancer. Individuals with CagA and VacA s1m1 strains develop more severe mucosal lesions. The Operative Link on Gastritis Assessment system allows determining the risk of cancer and defines atrophy as the typical lesion in the progression of chronic gastritis.
Objective: Relate the CagA and VacA genotypes of Helicobacter pylori with precursor lesions of gastric cancer.
Methods: A descriptive study was carried out in 62 patients. The variables included were the CagA and VacA genotypes of Helicobacter pylori and the OLGA stages (0, I, II, III, IV), which were related. The absolute frequency and the percentage were used as summary measures for qualitative variables. To evaluate the association between qualitative variables, the X2 test (chi square) was applied. A level of statistical significance p≤0.05 was accepted. To explore the relationship between two dichotomous variables, the relative risk was used. We worked with a confidence level of 95 %.
Development: 68 % of the patients with atrophy had a CagA genotype and 55 % had a VacA s1m1 genotype. 6 % of the patients with CagA were in stage 0; 11 % in stage I; 40 % in stage II and 16 % in stage III. 37 % of the patients with VacA s1m1 were stage II.
Conclusions: The CagA and VacA s1m1 genotypes were the most frequent and were related to the presence of gastric atrophy.
Downloads
References
2. Zhou Y, Li H-Y, Zhang J-J, Chen X-Y, Ge Z-Z, Li X-B. Operative link on gastritis Assessment stage is an appropriate predictor of early gastric cancer. World J Gastroenterol. 2016 [acceso: 1/11/2019]; 22(13): 3670-8]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814653/
3. Martínez Leyva L, Márquez Aleaga Y, Rodríguez González BL, Reyes Zamora O, Mora González SR. Presencia del gen cagA y de la citotoxina vacA del Helicobacter pylori en pacientes dispépticos. Rev Cub Med Mil. 2016 [acceso: 31/10/2019; 45(4):1-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572016000400009&nrm=iso
4. Asociación Médica Mundial AMM. Declaración de Helsinki de la AMM - Principios éticos para las investigaciones médicas en seres humanos. 64ª Asamblea General: 2013 octubre. Fortaleza, Brasil: Asociación Médica Mundial (AMM); 2013 [acceso: 19/01/2020]. Disponible en: http://www.wma.net/es/30publications/10policies/b3/
5. Koller J, Jensen M, Guerrer ML. Correlación Endoscópica-Histopatológica del Cag-A del Helicobacter pylori. Gac Med Bol. 2009 [acceso: 23/04/2020]; 32(1):13-15. Disponible en: https://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662009000100002&lng=es
6. Morales Díaz M, Corrales Alonso S, Vanterpool Héctor M, Avalos Rodríguez R, Salabert Tortolo I, Hernández Díaz O. Cáncer gástrico: algunas consideraciones sobre factores de riesgo y Helicobacter pylori. rev medica electronica. 2018 [acceso: 23/04/2020];40(2): [aprox. 11 p.]. Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/2513
7. Galvão de Azevêdo Ioná, Carneiro Izabel Cristina Leal Muniz, Tomiya Marília Tokiko Oliveira, Burgos Maria Goretti Pessoa de Araújo. Gastric cancer and associated factors in hospitalized patients. Nutr. Hosp. 2015 [acceso: 23/04/2020]; 32(1): 283-90. Disponible en: http://dx.doi.org/10.3305/nh.2015.32.1.9071
8. Zaidi SF. Helicobacter pylori associated Asian enigma: Does diet deserve distinction? World J Gastrointest Oncol. 2016 [acceso: 23/04/2020]; 8(4):341-50. DOI: 10.4251/wjgo.v8.i4.341
9. Torres Jiménez F, Torres Bayona C. Fisiopatología molecular en la infección por Helicobacter pylori. 2016 [acceso: 23/04/2020]; 32 (3). Disponible en: http://rcientificas.uninorte.edu.co/index.php/salud/article/viewArticle/8383/-10413
10. Uribe Echeverry PT, Acosta Cerquera MA, Arturo Arias BL, Jaramillo Arredondo Md, Betancur Pérez JF, Pérez Agudelo JM. Prevalencia genotípica de cagA y vacA en aislamientos de Helicobacter pylori de pacientes colombianos. Rev Cuba Med Tropical. 2019 [acceso: 23/04/2020];70 (3):[aprox. 10 p.] Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/265
11. Hierro González A, Garcia Vaca R, Lazo del Vallin S, Elvírez Gutiérrez A. Validación de prueba diagnóstica. Valor del ultrasonido hidrogástrico en la detección del cáncer gástrico. Revista Cubana de Investigaciones Biomédicas. 2018 [acceso: 23/04/2020];37(1):1-18. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/94
Published
How to Cite
Issue
Section
License
Authors who have publications with this Journal accept the following terms:
- The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
- The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
- Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.
