Adenopatías generalizadas como forma de presentación del lupus eritematoso sistémico
Abstract
Las adenopatías generalizadas son una manifestación frecuente, aunque usualmente inespecífica e indicativa de múltiples enfermedades. Se presenta una paciente joven, en el cual las adenopatías generalizadas fueron la primera manifestación clínica del lupus eritematoso sistémico. Es una paciente de 30 años de edad que tres meses antes del ingreso comenzó con cansancio fácil asociado a artralgia, pérdida de peso y aumento de volumen de miembros inferiores, al examen físico se constató palidez cutáneo mucosa, edemas en miembros inferiores, derrame pleural derecho, petequias en ambas piernas y adenopatías pequeñas generalizadas. Por los complementarios; anemia severa, poliserositis, estudio inmunológico positivo y biopsia de ganglio con adenitis inespecífica. Tratado con ácido fólico, cloroquina y prednisona, mejoró los síntomas y desaparecieron las adenopatías. Las adenopatías diseminadas encontradas clínica y ultrasonográficamente, fueron una variable de confusión para el diagnóstico rápido, al que se logró llegar mediante el adecuado contexto clínico, paraclínico y el estudio histopatológico.Downloads
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References
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13. Apor E, O'Brien J, M, Castillo JJ. Systemic lupus erythematosus is associated with increased incidence of hematologic malignancies: a meta-analysis of prospective cohort studies. Leuk Res. 2014;38(9):1067-71.
14. Monaco SE, Khalbuss WE, Pantanowitz L. Benign non-infectious causes of lymphadenopathy: A review of cytomorphology and differential diagnosis. Diagn Cytopathol. 2012;40(10):925-38.
15. Myeong S G, Kim Jo-Heon, Chai Lim G, Kim J. Clinic's pathological review of immunohistochemically defined Kikuchi-Fujimoto disease-including some interesting cases. Clinical Rheumatology. 2012;31(10):1463-9
2. Díaz R, González T, López F. Adenopatía y esplenomegalia. En: Acedo MS, Barrios A, Díaz R, Orche S, Sanz RM. Manual de Diagnóstico y Terapéutica Médica (4a. ed.). Madrid: MSD; 1998. p. 729-36.
3. Abba AA. Clinical Approach to lymphadenopathy. JK-Practitioner. 2011;16(1-2):1-8.
4. Bazemore AW, Smucker DR. Lymphadenopathy malignancy. Am Fam Physician. 2002;66(11):2103-10. N Engl J Med 2008;358(9):929-39.
5. Smith LW, Gelber AC, Petri M. Diffuse lymphadenopathy as the presenting manifestation of systemic lupus erythematosus. J Clin Rheumatol. 2013; 19(7):397-9.
6. Rademaker J. Hodgkin's and non-Hodgkin's lymphomas. Radiol Clin North Am. 2007;45(1):69-83.
7. Bichile T, Petri M. Incidence of lymphoma associated with underlying lupus: lessons learned from observational studies. Curr Opin Rheumatol. 2014;26(2):111-7.
8. Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum.2012;64(8):2677-86.
9. Vivekanandarajah A, Krishnarasa B, Hurford M, Gupta S. Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy. Clin Med Insights Pathol. 2012; 5: 7-10. Published online 2012 February 26. doi: 10.4137/CPath.S8685. PMCID: PMC3296495 10. Smith LW, Gelber AC, Petri M. Diffuse lymphadenopathy as the presenting manifestation of systemic lupus erythematosus. J Clin Rheumatol. 2013;19(7):397-9.
11. Xia JY, Chen XY, Xu F, Yang Y, Wang HY, Xue J. A case report of systemic lupus erythematosus combined with Castleman's disease and literature review. Rheumatol Int. 2012;32(7):2189-93.
12. Godman GC, Deitch AD, Klemperer P. The composition of the LE and hematoxylin bodies of systemic lupus erythematosus. Am J Pathol. 1958;34(1):1-23.
13. Apor E, O'Brien J, M, Castillo JJ. Systemic lupus erythematosus is associated with increased incidence of hematologic malignancies: a meta-analysis of prospective cohort studies. Leuk Res. 2014;38(9):1067-71.
14. Monaco SE, Khalbuss WE, Pantanowitz L. Benign non-infectious causes of lymphadenopathy: A review of cytomorphology and differential diagnosis. Diagn Cytopathol. 2012;40(10):925-38.
15. Myeong S G, Kim Jo-Heon, Chai Lim G, Kim J. Clinic's pathological review of immunohistochemically defined Kikuchi-Fujimoto disease-including some interesting cases. Clinical Rheumatology. 2012;31(10):1463-9
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Published
2018-06-12
How to Cite
1.
Suárez Rivero B, Suárez Rivero A, Rosell Suárez A, Bataille Ceriani M. Adenopatías generalizadas como forma de presentación del lupus eritematoso sistémico. Rev Cubana Med Milit [Internet]. 2018 Jun. 12 [cited 2025 Apr. 19];47(2):202-7. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/73
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