Inclusion of the 1-hour glucose tolerance test in the diagnosis of diabetes mellitus
Keywords:
diagnostic techniques and procedures, glucose tolerance test , diabetes, diabetes mellitusAbstract
The 1-hour glucose tolerance test is proposed as a more sensitive and practical method to detect intermediate hyperglycemia and type 2 diabetes mellitus compared to the 2-hour glucose tolerance test. OGTT-1h, with cut-off points of 155 mg/dL for IH and 209 mg/dL for T2DM, promises earlier detection and is a better predictor of future risk of T2DM. Although OGTT-1h faces challenges in its implementation, such as the need for validation in different populations and training of medical personnel, it is expected to improve the early detection and prevention of T2DM. Despite the lack of explicit endorsement from organizations such as the WHO, OGTT-1h represents a significant advance in the diagnosis of diabetes mellitus, with the potential to transform medical care and research.
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1. Bergman M, Manco M, Satman I, Chan J, Schmidt MI, Sesti G, et al. International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes [Internet]. Diabetes Research and Clinical Practice. 2024 [acceso: 11/02/2025]; 209 (2024):e111589. Disponible en: https://doi.org/10.1016/j.diabres.2024.111589
2. American Diabetes Association Professional Practice Committee. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2025 [Internet]. Diabetes Care. 2024 [acceso: 11/02/2025]; 48(Supplement_1):pS27-S49. Disponible en: https://doi.org/10.2337/dc25-S002
3. Abdul-Ghani MA, Tripathy D, DeFronzo RA. Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose [Internet]. Diabetes Care. 2006 [acceso: 11/02/2025]; 29(5): p1130-9. Disponible en: https://doi.org/10.2337/dc05-2179
4. Peddinti G, Bergman M, Tuomi T, Groop L. 1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers [Internet]. The Journal of clinical endocrinology and metabolism. 2019 [acceso: 11/02/2025]; 104(4):p1131-40. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC6382453/
5. Zhou B, Rayner AW, Gregg EW, Sheffer KE, Carrillo-Larco RM, Bennett JE, et al. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants [Internet]. The Lancet. 2024 [acceso: 11/02/2025]; 404(10467):p2077-93. Disponible en: https://doi.org/10.1016/S0140-6736(24)02317-1
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