Conservative treatment for post-dural puncture headache in obstetric patients
Keywords:
anesthesia, obstetric; conservative treatment; post-dural puncture headacheAbstract
Introduction: Post-dural puncture headache is a frequent complication following neuroaxial techniques in obstetrics. Its initial management is usually conservative, although the evidence supporting these interventions is heterogeneous.
Objective: To synthesize the available literature on the efficacy and use of conservative treatment for post-dural puncture headache in obstetric patients.
Method: A narrative literature review was conducted in the PubMed, Scopus, Web of Science, SciELO, Cochrane, and ClinicalKey databases. The search included articles published between 2015 and 2025, using the descriptors: obstetric anesthesia, post-dural puncture headache, and conservative treatment. Out of 90 identified articles, 30 that met the inclusion criteria were selected.
Development: The literature reports that prophylactic conservative measures such as prolonged bed rest, forced hydration, or the use of abdominal binders lack solid evidence to support their efficacy. Technique optimization (use of fine-gauge and pencil-point needles) is the most consistently supported preventive strategy. For established headache, simple oral analgesics in multimodal regimens and caffeine are the most frequently described interventions, although the evidence for their effectiveness is variable. Other pharmacological therapies show contradictory results or insufficient evidence.
Conclusions: A variety of conservative options are described for the management of post-dural puncture headache in obstetrics. However, the evidence supporting most of these interventions is of moderate to low quality and very heterogeneous, highlighting the need for more rigorous studies.
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References
1. Uppal V, Russell R, Sondekoppam RV, Ansari J, Baber Z, Chen Y, et al. Evidence-based clinical practice guidelines on postdural puncture headache: a consensus report from a multisociety international working group [Internet]. Reg Anesth Pain Med. 2024;49(7):471–501. DOI: https://doi.org/10.1136/rapm-2023-104817
2. Chacón Campos N, Pizarro Madrigal M, Guerrero Hines C. Cefalea post punción dural [Internet]. Rev. Méd. Sinerg. 2022 [acceso: 15/06/2025];7(6):e847. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/847
3. Gobel H. The International Classification of Headache ICHD-3 Disorders [Internet]. International Headache Society; 2018. [acceso: 14/06/ 2025]. Disponible en: https://ichd-3.org/
4. Abdelrazik RA, Toulan H, Ayoub SNB. Sphenopalatine ganglion block vs greater occipital nerve block in the management of post dural puncture headache in obstetric patients: a randomized clinical trial [Internet]. Anaesthesia, Pain & Intensive Care. 2024;28(1):68-73. DOI: https://doi.org/10.35975/apic.v28i1.2143
5. Calle Gómez MA, Devonish N, Gurumendi España IE, Borja Santillán MA. Dexametasona o hidrocortisona intravenosa como profilaxis de cefalea postpunción dural [Internet]. RECIMUNDO. 2021; 5(3):52-65. DOI: https://doi.org/10.26820/recimundo/5.(2).julio.2021.52-65
6. Ruck C, Lucas N. Punción dural accidental y cefalea postpunción dural. En: Brogly N, Manrique Muñoz S, Guasch Arévalo E, editores. Actualización de los Protocolos Asistenciales de la Sección de Anestesia-Analgesia Obstétrica de la SEDAR [Internet]. 3ª edición. Madrid: Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor (SEDAR); 2021. [acceso: 22/06/2025]. p. 352-61. Disponible en: https://www.sedar.es/index.php/secciones-y-grupos-de-trabajo/obstetricia/protocolos-obstetricia-p
7. García-U J, González-García N,Torres-Ferrús N, García-Azorín D, Molina-Martínez J. Diagnosis and treatment of disorders of intracranial pressure: consensus statement of the Spanish Society of Neurology’s Headache Study Group [Internet]. Neurología. 2025; 40(2):118-37. DOI: https://doi.org/10.1016/j.nrleng.2024.02.009
8. Escalona JR, Moraga AM, Castro C, Celis P. Frecuencia de Cesáreas en establecimientos públicos y privados de la Provincia de Concepción, Chile 2001-2019 [Internet]. Rev Chil Obstet Ginecol. 2022;87(6):369-74. DOI: https://doi.org/10.24875/RECHOG.22000071
9. Sarduy Nápoles MR, Molina Peñate LL, Tapia Llody G, Medina Arencibia C, Chiong Hernández DC. La operación cesárea en Cuba [Internet]. Rev Cubana Obstet Ginecol. 2018 [acceso: 15/07/2025]; 44(3): 1-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-600X2018000300001&lng=es
10. Abreu Brioso GL, Guzmán Martínez JK. Deambulación precoz e incidencia de cefalea pospunción dural en paciente obstétrica propuesta para cesárea electiva [Internet]. Rev Cuba Anestesiol Reanim. 2022 [acceso: 22/06/2025]; 21(2):1-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1726-67182022000200005&lng=es&tlng=es
11. Ruiz Chávez DA, Ocaña Arguello ND, Chilito Osorio VA, Álvarez Centy WA. Actualización en el manejo de la cefalea post punción lumbar [Internet]. RECIAMUC. 2023 [acceso: 11/06/2025];7(1):314-19. Disponible en: https://reciamuc.com/index.php/RECIAMUC/article/view/1013
12. Ge Z, Song G, Jing L. Eficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials [Internet]. BMC Pregnancy and Childbirth. 2023; 23(2):215. DOI: https://doi.org/10.1186/s12884-023-05531-7
13. Añel Liranza YB, Martínez Rondon A, Iraola Leyva MS, Mejias Pupo M, Cruz Carballosa Y, López Sánchez Y. Comportamiento de la cefalea post punción dural [Internet]. Rev Cubana Enfermer. 2015 [acceso: 16/07/2025];30(3):1-7. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03192014000300007&lng=es
14. Alatni R I, Alsamani R, Alqefari A. Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review [Internet]. Cureus. 2024; 16 (1): e52330. DOI: 10.7759/cureus.52330
15. Wu L., Chen S., Jiang X., Cheng Y, Zhang W. Opioids for the Prevention of Post-dural Puncture Headache in Obstetrics: A Systematic Review and Meta-analysis of Efficacy and Safety [Internet]. Pain physician. 2021 [acceso: 11/06/2025]; 24(7):E1155–E62. Disponible en: http://www.painphysicianjournal.com/linkout?issn=&vol=24&page=E1155
16. Azzi A, Saliba E, Stephan JC, Saba H, Hallit S, Chamandi S. Correlates of post-dural puncture headache and efficacy of different treatment options: a monocentric retrospective study [Internet]. British Journal of Pain. 2022; 16(2): 228-36. DOI: https://doi.org/10.1177/2049463721104
17. Paschoal AP, Vilaca MP, Machado AR, da Silva KRT, Gazarini L, da Silva AV. Cefaleia pós-punção dural – uma revisão de literatura / Post-dural puncture headache – a literature review [Internet]. Brazilian Journal of Health Review. 2020; 3(5): 12153–68. DOI: https://doi.org/10.34119/bjhrv3n5-062
18. Thon JN, Weigand MA, Kranke P, Siegler BH. Efficacy of therapies for post dural puncture headache [Internet]. Current opinion in anaesthesiology. 2024; 37(3):219–26. DOI: https://doi.org/10.1097/ACO.0000000000001361
19. Caicedo-Salazar Juliana, Ríos-Medina Ángela María. Nuevos abordajes y alternativas terapéuticas en el tratamiento de la cefalea pospunción dural [Internet]. Rev colom anestesiol. 2021; 49(3): e300. DOI: https://doi.org/10.5554/22562087.e951
20. Pérez Herrero ME. Abordaje de la cefalea postpunción dural. ¿Es posible evitarla o minimizarla? [Internet]. Revista de la sociedad española multidisciplinar del dolor. 2023 [acceso: 10/06/2025]; 3: 104-115 Disponible en: https://www.mpainjournal.com/abordaje-de-la-cefalea-postpuncion-dural-es-posible-evitarla-o-minimizarla1168
21. Arroyo Valencia VT, Ramírez Velasco LS, Ruiz Segarra RL, Morocho Constante, MP. Cefalea post punción lumbar [Internet]. RECIMUNDO. 2021; 5(4):29-36. DOI: https://doi.org/10.26820/recimundo/5.(4).oct.2021.29-36
22. Costa AC, Satalich JR, Al-Bizri E, Shodhan S, Romeiser JL, et Al. A ten-year retrospective study of post-dural puncture headache in 32,655 obstetric patients [Internet]. Can J Anesth/J Can Anesth. 2019; 66:1464-71. DOI: https://doi.org/10.1007/s12630-019-01486-6
23. Gupta A, von Heymann C, Magnuson A, Alahuhta S, Fernando R, et al. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study [Internet]. British Journal of Anaesthesia. 2020; 125 (6): 1045-55. DOI: 10.1016/j.bja.2020.07.061
24. Castell Jimeno C, Peñas Palomo C, Pretus Rubio S, Mariscal Flores M. Cefalea postpunción. Factores de riesgo, diagnóstico y tratamiento [Internet]. Rev Elec AnestesiaR. 2023; 15 (3):4. DOI: https://doi.org/10.30445/rear.v15i3.1137
25. Cartron E, Volteau C, Leroy M, Voisine A, Dauvergne JE, Ballet C, et al. Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority Randomized Controlled Trial [Internet]. PLoS ONE. 2025; 20(3): e0319481. DOI: https://doi.org/10.1371/journal.pone.0319481
26. Dávila FA, Roncancio G, Robayo A, Benavides D, Nevado Ardila N. Corticoides versus placebo en cefalea pospunción dural: Revisión sistemática y metaanálisis [Internet]. Rev Argent Anestesiol. 2017;75(1):13-22. DOI: http://dx.doi.org/10.1016/j.raa.2017.01.001
27. Wang Q, Zhu J, Ye L. Comment on “Comparative Study Between the Analgesic Effect of Prednisolone and Pregabalin in Managing Post Dural Puncture Headache after Lower-limb Surgeries” [Internet]. Pain Physician. 2025 [acceso: 11/10/2025]; 28:E93-E114. Disponible en: http://www.painphysicianjournal.com/linkout?issn=&vol=28&page=E107
28. Barati-Boldaji R, Shojaei-Zarghani S, Mehrabi M, Amini A, Reza Safarpour A. Post-dural puncture headache prevention and treatment with aminophylline or theophylline: a systematic review and meta-analysis [Internet]. Anesth Pain Med. 2023; 18 (2):177-185. DOI: https://doi.org/10.17085/apm.22247
29. Ashoor TM., Abd ElKader AM., Gadalla AA., Esmat IM., & Hasseb AM. Adjuvants to Conventional Management of Postdural Puncture Headache Following Obstetric Surgery Under Spinal Anesthesia: Mirtazapine vs. Sumatriptan. [Internet]. Pain physician. 2025 [acceso: 11/10/2025]; 28(1): 39–49. Disponible en: http://www.painphysicianjournal.com/linkout?issn=&vol=28&page=39
30. Jing W, Ma Y, Wan Y, Li H. Efficacy and Safety of Prophylactic Intrathecal or Epidural Normal Saline for Preventing Post-Dural Puncture Headache After Dural Puncture: A Meta-Analysis and Systematic Review [Internet]. Journal of Pain Research. 2025; 18: 915–27. DOI: https://doi.org/10.2147/JPR.S494237
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