COVID-19 in patients with chronic kidney disease on hemodialysis

Authors

Keywords:

SARS-CoV-2, COVID-19, chronic kidney disease, hemodialysis.

Abstract

Introduction: The recent SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Hemodialysis patients due to their characteristics are especially vulnerable.
Objective:
 To specify the characteristics of patients with COIVID-19, chronic kidney disease, on hemodialysis.
Methods: Descriptive, cross-sectional study in 14 patients on hemodialysis positive for SARS-CoV-2. All the cases were diagnosed positive through the rRT-PCR test. The source of infection and the clinical picture presented at the time of diagnosis were identified. All patients underwent blood tests at the beginning.
Results: 92.8% (13 patients) had previous contact with a positive case. At diagnosis 9 (64.28%) patients had symptoms and 5 (35.7%) were asymptomatic. Dyspnea (8 patients), fever and dry cough (7 patients) predominated. Lymphopenia was observed with an average of 0.12 in symptomatic patients, and 0.31 in asymptomatic patients. There was an increase in the mean ferritin of 3096 µg/l in symptomatic patients by 1001 µg/l in asymptomatic patients, and in C-reactive protein values, with an average of 67 mg/l in symptomatic patients by 18.2 mg/l in asymptomatic patients.
Conclusions: In the hemodialysis patients with chronic kidney disease diagnosed with COVID-19, there were no differences in sex in terms of symptoms, with lymphopenia and the presence of elevated inflammatory markers at the time of diagnosis, mainly in symptomatic patients.

Downloads

Download data is not yet available.

References

1. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020 [acceso: 20/04/2020];97(5):829-38. Disponible en: http://www.sciencedirect.com/science/article/pii/S0085253820302556

2. Lipsitch M, Swerdlow DL, Finelli L. Defining the Epidemiology of Covid-19-Studies Needed. N Engl J Med. 2020[acceso: 20/05/2020];382(13):1194-96. DOI: 10.1056/NEJMp2002125

3. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020[acceso: 16/05/2020];382(8):727-33. DOI: 10.1056/NEJMoa2001017

4. Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 Critically III Patients with COVID-19 with Convalescent Plasma. Jama. 2020[acceso: 22/05/2020];323(16):1582-89. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/32219428

5. Bajema KL, Oster AM, McGovern OL, Lindstrom S, Stenger MR, Anderson TC, et al. Persons Evaluated for 2019 Novel Coronavirus - United States, January 2020. MMWR Morb Mortal Wkly Rep. 2020[acceso: 28/03/2020];69(6):166-70. DOI: 10.15585/mmwr.mm6906e1

6. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc. 2020[acceso: 15/05/2020];323(11):1061-9. DOI: 10.1001/jama.2020.1585

7. Park HC, Lee SH, Kim J, Kim DH, Cho A, Jeon HJ, et al. Effect of isolation practice on the transmission of Middle East respiratory syndrome coronavirus among hemodialysis patients: A 2-year prospective cohort study. Medicine. 2020[acceso: 25/03/2020];99(3): e18782. Disponible en: https://journals.lww.com/md-journal/fulltext/2020/01170/effect_of_isolation_practice_on_the_transmi-ssion.43.aspx

8. de Francisco ALM, Pérez Canga JL. Coronavirus y Riñón: actualización completa 09 de Junio de 2020. Barcelona: Nefrología al día, Sociedad Española de nefrología; 2020.[acceso: 29/05/2020]. Disponible en: https://www.nefrologiaaldia.org/es-articulo-coronavirus-rinon-actualizacion-completa-09-305

9. Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade. Nephron. 2020[acceso: 10/05/2020];144:213-21. DOI: 10.1159/000507305

10. Beltrán PAG, Carranza ED, Rubio FM, Márquez MP. Recomendaciones para el manejo del paciente con enfermedad renal crónica con SARS-Cov-2. Enfermería Clínica. 2020[acceso: 30/05/2020];31:S55-61. DOI: 10.1016/j.enfcli.2020.05.017

11. Albalate M, Arribas P, Torres E, Cintra M, Alcázar R, Puerta M, et al. Alta prevalencia de COVID-19 asintomático en hemodiálisis: Aprendiendo día a día el primer mes de pandemia de COVID-19. Nefrología. 2020[acceso: 30/04/2020];40(3):279-86. DOI: 10.1016/j.nefro.2020.04.005

12. Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study, China. Signal Transduction and Targeted Therapy. 2020[acceso: 12/05/2020];5(1):33. DOI: 10.1038/s41392-020-0148-4

13. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020[acceso: 22/03/2020];323(15):1488-94. DOI: 10.1001/jama.2020.3204

14. Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A metanalysis. Clinica Chimica Acta. 2020[acceso: 10/06/2020];505:190-1. DOI: 10.1016/j.cca.2020.03.004

15. Zhou B, She J, Wang J, Ma X. Utility of ferritin, procalcitonin, and C-reactive protein in severe patients with 2019 novel coronavirus disease. BMC Pulmonary Research Square [preprint]. [actualizado: 19/03/2020; acceso: 27/05/2020]:[12 p]. DOI: 10.21203/rs.3.rs-18079/v1

16. Ma Y, Diao B, Lv X, Zhu J, Liang W, Liu L, et al. 2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China. medRxiv [preprint]. [actualizado: 27/02/2020; acceso: 17/03/2020]. Disponible en: https://www.medrxiv.org/content/10.1101/2020.02.24.20027201v2.full.pdf

17. Alberici F, Delbarba E, Manenti C, Econimo L, Valerio F, Pola A, et al. Management of patients on dialysis and with kidney transplant during SARS-CoV-2 (COVID-19) pandemic in Brescia, Italy. Kidney Int Rep. 2020[acceso: 16/05/2020];5(5):580-5. DOI: 10.1016/j.ekir.2020.04.001

18. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis. Clin Chem Lab Med. 2020[acceso: 19/05/2020];58(7):1021-28. DOI: 10.1515/cclm-2020-0369

19. Pérez Abreu MR, Gómez Tejeda JJ, Dieguez Guach RA. Características clínico-epidemiológicas de la COVID-19. Rev haban cienc méd. 2020[acceso: 11/05/2020];19(2):e_3254. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3254/2505

Published

2021-02-13

How to Cite

1.
de Armas Gil T, Herrera Oropesa Y, Barroso Cruz J, Joseph Planas HR, Rey Torres AB, Fuentes Abreu J, et al. COVID-19 in patients with chronic kidney disease on hemodialysis. Rev Cubana Med Milit [Internet]. 2021 Feb. 13 [cited 2025 Jan. 8];50(1):e0210859. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/859

Issue

Section

Research Article

Most read articles by the same author(s)