Clinical laboratory parameters in patients with COVID-19

Authors

Keywords:

laboratory parameters, COVID-19, SARS-CoV-2, biomarkers.

Abstract

Introduction: Knowing the alterations in clinical laboratory tests is useful in the diagnosis and progress of patients with COVID-19.
Objective: To describe the clinical laboratory parameters in patients diagnosed with COVID-19.
Methods: Descriptive study in 82 hospitalized patients with COVID-19. The variables analyzed were age, sex, comorbidity, patient report, discharge status, hemoglobin, white blood cell count, absolute neutrophil count, absolute lymphocyte count, platelet count, erythrocyte sedimentation rate, D-dimer, creatinine, urea, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase, neutrophil / lymphocyte and platelet / lymphocyte ratio.
Results: The average age was 55.61 ± 22.04, the majority were female (57.3%), hypertensive (41.5%), 18.3% reported serious and 14.6% died. Advanced age and comorbidity were associated with the severity report. There was a significant decrease in hemoglobin, lymphocytes; elevated erythrocyte sedimentation rate, D-dimer, creatinine, γ-glutamyl transpeptidase, and lactate dehydrogenase, especially in severe patients. The neutrophil / lymphocyte and platelet / lymphocyte ratio warned about the worsening of the patient and the possibility of death.
Conclusions: The patients a mean age of 55.61, female, with arterial hypertension; they were discharged alive, reported as not serious. Mean hemoglobin values decrease, global lymphocyte count, especially in severe patients; increases D-dimer, creatinine, ALT, AST, ALP, GGT, and LD. The neutrophil / lymphocyte and platelet / lymphocyte ratio show high mean values, especially in severely ill patients and in those who died.

Downloads

Download data is not yet available.

Author Biography

Naivy Sánchez Vera, Hospital Miliar Manuel Fajardo Rivero, Villa Clara

especialista de primer grado en Laboratorio Clínico y MGI

References

1. Palacios Cruz M, Santos E, Velázquez Cervantes MA, León Juárez M. COVID-19, una emergencia de salud pública mundial. Rev Clín Esp. 2020 [acceso: 29/09/2020];20(221-1):55-61. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102523/

2. Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M. Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med. 2020 [acceso: 04/06/2020];58(7):1095-9. Disponible en: https://www.degruyter.com/configurable/contentpage/journals$002fcclm$002f5-8$002f7$002farticle-p1095.xml

3. Esquivel Sosa L, Martínez-Fortún Amador M, Águila Carbelo M. Pandemias de 1918 y 2020, similitudes y diferencias. Apuntes del Dr. José Andrés Martínez-Fortún. Acta Médica del Centro. 2020 [acceso: 30/09/2020];14(3):[aprox. 9 p.]. Disponible en: https://www.revactamedicacentro.sld.cu/index.php/amc/article/view/1309

4. Espinosa Brito A. COVID-19: rápida revisión general. Anales de la Academia de Ciencias de Cuba. 2020 [acceso: 24/06/2020];10(2): [aprox. 6 p.]. Disponible en: https://www.revistaccuba.sld.cu/index.php/revacc/article/view/828

5. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis T, Politou M, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020 [acceso: 24/06/2020]; 95(7)1-14. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.25829

6. Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, et. al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 2020 [acceso: 24/06/2020];31(4): 490-6. Disponible en: https://doi.org/10.1080/09537104.2020.1754383

7. Yang A, Liu J, Tao W, Lib H. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020 [acceso: 8/11/2020];88(106504): [aprox. 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152924/

8. Acosta G, Escobar G, Bernaola G, Alfaro J, Taype W, Marcos C, et al. Description of patients with severe covid-19 treated in a national referral hospital in Peru. Rev Peru Med Exp Salud Publica. 2020 [acceso: 8/11/2020]; 37(2): 253-8. Disponible en: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5437/3713

9. Solís Cartas U, Martínez Larrarte JP. Opciones terapéuticas al síndrome de liberación de citocinas en pacientes con la COVID-19. Rev Cubana Med Milit. 2020 [acceso: 29/09/2020];49(3): e0200783. Disponible en: https://www.revmedmilitar.sld.cu/index.php/mil/article/view/783

10. Ferrari D, Cabitza F, Carobene A, Locatelli M. Routine blood tests as an active surveillance to monitor COVID-19 prevalence. A retrospective study. Acta Bio Med. 2020 [acceso: 9/11/2020];91(3): e2020009. Disponible en: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10218

11. Pérez Fernández GA. ¿Es la comorbilidad cardiovascular la causante de la elevación de la proteína C reactiva en pacientes positivos a la COVID-19? Acta Médica del Centro. 2020[30/09/2020];14(3): [aprox. 8 p.]. Disponible en: https://www.revactamedicacentro.sld.cu/index.php/amc/article/view/1294

12. Parra Izquierdo V, Florez Sarmiento C, Romero Sanchez MC. Inducción de "tormenta de citocinas" en pacientes infectados con SARS- CoV-2 y desarrollo de COVID-19. ¿Tiene el tracto gastrointestinal alguna relación en la gravedad? Rev Colomb Gastroenterol. 2020 [acceso: 29/09/2020];35(1):21-9. Disponible en: https://doi.org/1022516/25007440.539

13. Liu J, Liu Y, Xiang P, Pu L, Xiong H, Li C, et al. Neutrophil-to-Lymphocyte Ratio Predicts Severe Illness Patients with 2019 Novel Coronavirus in the Early Stage. J Transl Med. 2020 [acceso: 29/09/2020];18(206):2-12. Disponible en: https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7237880&blobtype=pdf

14. Basbus L, Lapidus MI, Martingano I, Puga MC, Pollán J. Índice neutrófilo-linfocito como factor pronóstico de COVID-19. Medicina. 2020 [acceso: 29/10/2020]; 80(III):1-6 Disponible en: https://www.medicinabuenosaires.com/indices-de-2020/volumen-80-ano-2020-s-3-indice/indice_covid/

15. Ballesté R. El laboratorio en el diagnóstico de COVID-19 en Uruguay: resultados y desafíos. Rev. Méd. Urug. 2020 [acceso: 29/09/2020];36(3):1-8. Disponible en: https://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902020000300001&lng=es

Downloads

Published

2021-06-14

How to Cite

1.
Vera NS, Saavedra Hernández D, Hidalgo Mesa CJ, Aguila López M, Abreu Gutiérrez G, Herrera González V, et al. Clinical laboratory parameters in patients with COVID-19. Rev Cubana Med Milit [Internet]. 2021 Jun. 14 [cited 2025 Apr. 2];50(2):e02101171. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/1171

Issue

Vol. 50 No. 2 (2021): April - June

Section

Research Article

License

Authors who have publications with this Journal accept the following terms:

  • The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
  • The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
  • Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.