Effect of autologous platelet-rich plasma treatment on patients with thin endometrium

Authors

  • Tung Nguyen Thanh Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam https://orcid.org/0000-0003-3790-9480
  • Ai Hoang Van Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam
  • Son Trinh The Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam https://orcid.org/0000-0002-3807-9645
  • Lan Do Ngoc Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam
  • Hang Doan Thi Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam
  • Trang Quan Van Military Institute of Clinical Embryology and Histology, Millitary Medical University, Hanoi, Vietnam
  • Khoa Ba Tran 108 Millitary Central Hospital, Hanoi, Vietnam
  • Sang Trieu Tien Dept. Biology and Medical Genetic, Vietnam Military Medical University, Hanoi, 121-08, Vietnam

Keywords:

frozen embryo transfer, platelet-rich plasma, thin endometrium, endometrium thickness.

Abstract

Introduction: The success of frozen embryo transfer cycles depends on a delicate interaction between embryo quality and endometrium. Low pregnancy rates are associated with a thin endometrium.
Objective: To evaluate the effect of autologous platelet-rich plasma treatment on patients with thin endometrium.
Methods: In 34 patients with thin endometrium (< 7 mm), canceled in the previous frozen embryo transfer cycles, autologous platelet-rich plasma was prepared, from autologous peripheral vein blood; intrauterine infusion was given during hormone replacement therapy in frozen embryo transfer cycles. Frozen embryo transfer was performed when the endometrium thickness reached ≥ 7mm.
Results: Six patients canceled the embryo transfer cycle due to endometrium thickness did not reach 7 mm; 28 patients got endometrial thickness ≥ 7 mm and performed frozen embryo transfer. The endometrial thickness was 7.5 ± 0.8 mm, which was significantly thicker than in the previous cycles (5.6 ± 0.79 mm) with p< 0.002, the implantation rate was 23.07 %, and the clinical pregnancy rate was 12/28 (42.8 %).
Conclusion: Autologous platelet-rich plasma improves the endometrial thickness and the pregnancy rate outcomes in women with thin endometrium.

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Published

2022-06-10

How to Cite

1.
Nguyen Thanh T, Hoang Van A, Trinh The S, Do Ngoc L, Doan Thi H, Quan Van T, et al. Effect of autologous platelet-rich plasma treatment on patients with thin endometrium. Rev Cubana Med Milit [Internet]. 2022 Jun. 10 [cited 2025 Apr. 3];51(2):e02201802. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/1802

Issue

Vol. 51 No. 2 (2022): April - June

Section

Research Article

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