Association between low birth weight and congenital malformations
Keywords:
low-birth-weight infant, congenital abnormalities, fetal growth retardation, toxoplasmosis.Abstract
Introduction: Congenital anomalies are structural or functional defects during intrauterine life. The relationship between low birth weight and predisposition to a congenital anomaly is not well known.Objective: To evaluate the association between low birth weight and the manifestation of congenital anomaly in neonates.
Method: A cross-sectional study was performed. The study population were mothers who delivered neonates in a hospital in Asuncion, Paraguay, in 2018. Data collection cards were created with maternal and neonatal characteristics. The outcome variable was congenital malformations at birth. The exposure variable was low birth weight, defined as the clinical report of weight less than 2 500 grams in a neonate.
Results: Out of 225 women, 26,7 % were found to have presented mother-to-neonatal transmission infections (60/165); 102 (45,3 %) were preterm and 79 (35,1 %) had congenital malformations. A positive association was evidenced between history of low birth weight and congenital malformations (PR= 2,32; CI 95 %: 1,68-3,20).
Conclusions: There is a positive association between a history of low birth weight and congenital malformations.
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References
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16. Montes-Núñez S, Chávez-Corral DV, Reza-López S, Sanin LH, Acosta- Maldonado B, Levario-Carrillo M. Birth weight in children with birth defects. Birt Defects Res A Clin Mol Teratol. 2011; 91(2):102-7. DOI: 10.1002/bdra.20751
17. Ngo S, Profit J, Gould JB, Lee HC. Trends in patent ductus arteriosus diagnosis and management for very low birth weight infants. Pediatrics. 2017; 139(4): e20162390. DOI: 10.1542/peds.2016-2390
18. Linhart Y, Bashiri A, Maymon E, Shoham-Vardi I, Furman B, Vardi H, et al. Congenital anomalies are an independent risk factor for neonatal morbidity and perinatal mortality in preterm birth. Eur J Obstet Gynecol Reprod Biol. 2000; 90(1):43-9. DOI: 10.1016/s0301-2115(99)00196-7
19. Miquel-Verges F, Mosley BS, Block AS, Hobbs CA. A spectrum project: preterm birth and small-for-gestational age among infants with birth defects. J Perinatol. 2015; 35(3):198-203. DOI: 10.1038/jp.2014.180
2. Kouame BD, n’guetta-Brou IA, Kouame GSY, Sounkere M, Koffi M, Yaokreh JB, et al. Epidemiology of congenital abnormalities in West Africa: Results of a descriptive study in teaching hospitals in Abidjan: Cote d’Ivoire. Afr J Paediatr Surg. 2015; 12(1):51-5. DOI: 10.4103/0189-6725.150983
3. Boyle B, Addor M-C, Arriola L, Barisic I, Bianchi F, Csáky-Szunyogh M, et al. Estimating Global Burden of Disease due to congenital anomaly: an analysis of European data. Arch Dis Child - Fetal Neonatal Ed. 2018; 103(1):f22-8. DOI: 10.1136/archdischild-2016-311845
4. Cosme HW, Lima LS, Barbosa LG. Prevalence of congenital anomalies and their associated factors in newborns in the city of São Paulo from 2010 to 2014. Rev Paul Pediatr. 2017; 35(1): 33-8. DOI: 10.1590/1984-0462/;2017;35;1;00002
5. Concepción-Zavaleta M, Cortegana-Aranda J, Zavaleta-Gutierrez F, Ocampo-Rugel C, Estrada-Alva L. Factores maternos asociados a malformaciones congénitas en recién nacidos de un Hospital de Trujillo, Perú. Rev Cuerpo Med HNAAA. 2019; 9(2):99-104. DOI: 10.35434/rcmhnaaa.2016.92.128
6. Ambou Frutos I, Lastra Pérez L, Vilches Lescaille D, Osorio Illas L, Ramos López M, Rodríguez Ahuar N. Manifestaciones clínicas asociadas al síndrome de TORCH. Rev Cubana Oftalmol. 2018 [acceso: 04/05/2022]; 31(1):132-144. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762018000100013
7. Michael E, Wadhwani R, Resident S. Urinary tract infection and its effect on outcome of pregnancy. Indian J Obstet Gynecol Res. 2017 [acceso: 04/05/2022]; 4(2):108-11. Disponible en: https://www.ijogr.org/article-details/4048
8. Wang Y, Li S, Ma N, Zhang Q, Wang H, Cui J, et al. The association of ToRCH infection and congenital malformations: A prospective study in China. Eur J Obstet Gynecol Reprod Biol. 2019; 240:336-40. DOI: 10.1016/j.ejogrb.2019.04.042
9. Dolan SM, Gross SJ, Merkatz IR, Faber V, Sullivan LM, Malone FD, et al. The Contribution of Birth Defects to Preterm Birth and Low Birth Weight. Obstet Gynecol. 2007; 110(2 Pt 1):318-24. DOI: 10.1097/01.AOG.0000275264.78506.63
10. Silva-Díaz H, Arriaga-Deza EV, Failoc-Rojas VE, Alarcón-Flores YR, Rojas-Rojas SY, Becerra-Gutiérrez LK, et al. Seroprevalence of toxoplasmosis in pregnant women and its associated factors among hospital and community populations in Lambayeque, Peru. Rev Soc Bras Med Trop. 2020; 53:e20190164. DOI: 10.1590/0037-8682-0164-2019
11. Eiríksdóttir VH, Ásgeirsdóttir TL, Bjarnadóttir RI, Kaestner R, Cnattingius S, Valdimarsdóttir UA. Low birth weight, small for gestational age and preterm births before and after the economic collapse in Iceland: a population based cohort study. PLoS One. 2013; 8(12):e80499. DOI: 10.1371/journal.pone.0080499
12. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in Metropolitan Atlanta, 1998-2005. J pediatr. 2008; 153(6):807-13. DOI: 10.1016/j.jpeds.2008.05.059
13. Abdul Hamid MP, Ali H, Abbas F. Congenital Anomalies in the Offspring of Mothers with Torch Infections during Pregnancy. Ophtalmol Update. 2015 [acceso: 04/05/2022]; 13:325-8. Disponible en: https://ophthalmologyupdate.org/public/site/oct-dec2015.pdf
14. Leung KKY, Hon KL, Yeung A, Leung AKC, Man E. Congenital infections in Hong Kong: an overview of TORCH. Hong Kong Med J. 2020; 26(2):127-38. DOI: 10.12809/hkmj198287
15. Fochi MM, Baring S, Spegiorin LC, Vaz-Oliani DC, Galão EA, Oliani AH, de Mattos LC, de Mattos CC. Prematurity and Low Birth Weight did not Correlate with Anti-Toxoplasma gondii Maternal Serum Profiles--a Brazilian Report. PLoS One. 2015; 10(7):e0132719. DOI: 10.1371/journal.pone.0132719
16. Montes-Núñez S, Chávez-Corral DV, Reza-López S, Sanin LH, Acosta- Maldonado B, Levario-Carrillo M. Birth weight in children with birth defects. Birt Defects Res A Clin Mol Teratol. 2011; 91(2):102-7. DOI: 10.1002/bdra.20751
17. Ngo S, Profit J, Gould JB, Lee HC. Trends in patent ductus arteriosus diagnosis and management for very low birth weight infants. Pediatrics. 2017; 139(4): e20162390. DOI: 10.1542/peds.2016-2390
18. Linhart Y, Bashiri A, Maymon E, Shoham-Vardi I, Furman B, Vardi H, et al. Congenital anomalies are an independent risk factor for neonatal morbidity and perinatal mortality in preterm birth. Eur J Obstet Gynecol Reprod Biol. 2000; 90(1):43-9. DOI: 10.1016/s0301-2115(99)00196-7
19. Miquel-Verges F, Mosley BS, Block AS, Hobbs CA. A spectrum project: preterm birth and small-for-gestational age among infants with birth defects. J Perinatol. 2015; 35(3):198-203. DOI: 10.1038/jp.2014.180
Published
2022-07-22
How to Cite
1.
Insfran G, Aveiro R, Gomez A, Melgarejo P, Bazzano J, Martinez F, et al. Association between low birth weight and congenital malformations. Rev Cubana Med Milit [Internet]. 2022 Jul. 22 [cited 2024 Dec. 29];51(3):e02202091. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2091
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