Nasal-type extranodal T-cell lymphoma/Natural killer masked in sinusopathy, a frequent manifestation
Keywords:
NK/T-cell lymphoma, lethal midline granuloma, nose neoplasms, sinusitis.Abstract
Introduction: Nasal-type extranodal natural killer/cytotoxic T-cell lymphoma is rare but has a high mortality rate. The clinical manifestations of the disease can mimic a paranasal sinus infection. Objective: To present the clinical manifestations of a 34-year-old patient diagnosed with nasal-type extranodal natural killer/cytotoxic T-cell lymphoma.Clinical case: A 34-year-old male patient with recurrent greenish fetid rhinorrhea and obstruction in the right nostril is presented. In the initial evaluation, it suggests chronic sinusitis, however, due to the worsening of the clinical manifestations, a computed tomography is performed that shows lesions suggestive of neoplastic infiltration, a biopsy of the lesion confirms the diagnosis of T-cell lymphoma/extranodal natural killer.
Conclusions: Nasal-type extranodal natural killer/cytotoxic T-cell lymphomas are considered rare neoplasms characterized by a rapidly progressive pattern with bone involvement; in its initial stage it presents clinical manifestations similar to sinusitis. Computed tomography and histopathology are essential in the diagnosis of the disease.
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References
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2. Saavedra Ramírez JD. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso. Case Rep Oncol. 2017; 10(3):1092-7. DOI: 10.1159/000484583
3. Yamaguchi M, Suzuki R, Oguchi M. Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type. Blood. 2018; 131(23):2528-40. DOI: 10.1182/blood-2017-12-791418
4. van Doesum JA, Niezink AGH, Huls GA, Beijert M, Diepstra A, van Meerten T. Extranodal Natural Killer/T-cell Lymphoma, Nasal Type: Diagnosis and Treatment. Hemasphere. 2021; 5(2):e523. DOI: 10.1097/HS9.0000000000000523
5. Lisowska G, Zięba N, Stryjewska-Makuch G, Ścierski W, Miśkiewicz-Orczyk K, Misiołek M. Natural Killer (NK)//T-Cell Lymphoma, Nasal Type, with Periorbital Involvement: A Case Report and Literature Review. Am J Case Rep. 2020; 21:e926599. DOI: 10.12659/AJCR.926599
6. Termote K, Dierickx D, Verhoef G, Jorissen M, Tousseyn T, Mombaerts I. Series of extranodal natural killer/T-cell lymphoma, nasal type, with periorbital involvement. Orbit. 2014; 33(4):245-51. DOI: 10.3109/01676830.2014.902478
7. Min Z, Bhanot N. A Great Masquerader: Nasal Type, Extranodal Natural Killer/T-cell Lymphoma Presenting as Recalcitrant Bacterial Sinusitis and Periorbital Cellulitis. Case Rep Med. 2020; 2020:6646693. DOI: 10.1155/2020/6646693
8. Gill H, Liang RH, Tse E. Extranodal natural-killer/t-cell lymphoma, nasal type. Adv Hematol. 2010; 2010:627401. DOI: 10.1155/2010/627401
9. Harabuchi Y, Takahara M, Kishibe K, Nagato T, Kumai T. Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress. Front Pediatr. 2019; 7:141. DOI: 10.3389/fped.2019.00141
Published
2023-01-17
How to Cite
1.
Bernal J, Tuta-Quintero E, Balcazar E, Franco D, Kuan JC, Collazos E, et al. Nasal-type extranodal T-cell lymphoma/Natural killer masked in sinusopathy, a frequent manifestation. Rev Cubana Med Milit [Internet]. 2023 Jan. 17 [cited 2025 Jan. 10];52(1):e02302222. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2222
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