Effects of hyperbaric pressure on the oxidative stress status in healthy subjects
Keywords:
biomarkers, catalase, decompression, free radicals, healthy volunteers, malondialdehyde, oxidative stress, superoxide dismutase.Abstract
Introduction: In the hyperbaric pressure environment the partial pressure of each gas component increases, which increases oxygen partial pressure. This causes the generation of free radicals and oxidative stress.
Objective: To determine the effects of hyperbaric pressure on the oxidative stress status in healthy subjects.
Methods: 29 healthy men performed standardized hyperbaric chamber dive to a depth of 30 meters of water (msw) for 30 minutes. Blood samples were collected before compression, immediately after decompression and 1 hour after decompression. The levels of Malondialdehyde, Catalase and Superoxide Dismutase were measured in blood samples.
Results: Malondialdehyde activity increased immediately after decompression and recovered at 1 hour after decompression. Superoxide Dismutase enzyme activity decreased immediately after decompression as well as 1 hour after decompression. Catalase enzyme activity increased immediately after decompression, which was significant at 1 hour after decompression.
Conclusion: Changes in the biologic markers Malondialdehyde, Catalase and Superoxide Dismutase suggest the appearance of oxidative stress under the influence of a hyperbaric pressure environment.
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References
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2. Bin-Jaliah I, Dallak M, Haffor ASA. Effect of hyperoxia on the ultrastructural pathology of alveolar epithelium in relation to glutathione peroxidase, lactate dehydrogenase activities, and free radical production in rats, rattus norvigicus. Ultrastruct Pathol. 2009; 33:112-22. DOI: 10.1080/01913120902889179
3. Jamieson D, Chance B, Cadenas E, Boveris A. The relation of free radical production to hyperoxia. Annu Rev Physiol. 1986; 48:703-19. DOI: 10.1146/annurev.ph.48.030186.003415
4. Pott F, Westergaard P, Mortensen J, Jansen EC. Hyperbaric oxygen treament and pulmonary function. Undersea Hyperb Med. 1999 [access: 01/09/1999]; 26(4):225-28. Available from: https://pubmed.ncbi.nlm.nih.gov
5. Ferrer MD, Sureda A, Batle JM, Tauler P, Tur JA, Pons A. Scuba diving enhances endogenous antioxidant defenses in lymphocytes and neutrophils. Free Radic Res. 2007; 41(3): 274-281. DOI: 10.1080/10715760601080371
6. Sureda A, Batle JM., Ferrer MD, Mestre-Alfaro A, Tur JA, Pons A. Scuba diving activates vascular antioxidant system. Int J Sports Med. 2012; 33:531-6. DOI: 10.1055/s-0031-1297957
7. Gasier HG, Fothergill DM. Oxidative stress, antioxidant defenses and nitric oxide production following hyperoxic exposures. Undersea Hyperb Med. 2013 [access: 21/05/2013]; 40(2):125-34. Available from: https://pubmed.ncbi.nlm.nih.gov/23682544/
8. Kasperczyk S, Birkner E, Kasperczyk A, Zalejska-Fiolka J. Activity of superoxide dismutase and catalase in people protractedly exposed to lead compounds. Ann Agric Environ Med. 2004 [access: 11/10/2004]; 11: 291 - 296. Available from: https://www.proquest.com/openview/10c7238e1d4f603cf07810938d672190/1?pq-origsite=gscholar&cbl=5221234
9. Laher I. Systems biology of free radicals and antioxidants. Vancouver, British Columbia, Canada: Springer; 2014.
10. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014; 94:329 - 354. DOI: 10.1152/physrev.00040.2012
11. Sureda A, Ferrer MD, Batle JM, Tauler P, Tur JA, Pons A. Scuba diving increases erythrocyte and plasma antioxidant defenses and spares NO without oxidative damage. Med Sci Sports Exerc. 2009; 41(6):1271-6. DOI: 10.1249/MSS.0b013e3181951069
12. Kozakiewicz M, Kędziora-Kornatowska K, Kaczerska D, Siermontowski P, Olszanski R, Krefft K. Influence of exposure in hyperbaric chambers on selected parameters of oxidative stress in professional divers. Undersea Hyperb Med. 2018 [access: 01/01/2018]; 45(1):49-54. https://europepmc.org/article/med/29571232
13. Bhutia Y, Ghosh A, Sherpa ML, Pal R, Mohanta PK. Serum malondialdehyde level: surrogate stress marker in the sikkimese diabetics. J Nat Sci Biol Med. 2011; 2(1):107-12. DOI: 10.4103/0976-9668.82309
14. Radojevic-Popovic R, Zivkovic V, Jeremic N, Sretenovic J, Velicanin N, Bradic J, et al. An evaluation of the redox state in professional scuba divers. Undersea Hyperb Med. 2015 [access: 01/09/2015]; 42(5):409-16. https://pubmed.ncbi.nlm.nih.gov/26591980/
15. Zwart SR., Kala G, Smith SM. Body iron stores and oxidative damage in humans increased during and after a 10- to 12-day undersea dive. J Nutr. 2008; 139:90-5. DOI: 10.3945/jn.108.097592
Published
2023-04-21
How to Cite
1.
Nguyen PM, Nguyen BH, Phan MV, Bui HD. Effects of hyperbaric pressure on the oxidative stress status in healthy subjects. Rev Cubana Med Milit [Internet]. 2023 Apr. 21 [cited 2025 Jan. 9];52(2):e02302506. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2506
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