Association between diabetes mellitus and corpus cavernosum arterial insufficiency in patients with erectile dysfunction

Authors

Keywords:

diabetes mellitus, peripheral arterial disease, erectile dysfunction.

Abstract

Introduction: Erectile dysfunction is highly prevalent in the population and vascular and neural processes are involved in its pathophysiology, including those related to late complications of diabetes mellitus.
Objective: To determine the association between diabetes mellitus and corpus cavernosum arterial insufficiency in patients with erectile dysfunction.
Methods: Cross-sectional study of secondary data analysis conducted in a private health facility in Lima during the year 2022. Patients with a confirmed diagnosis of erectile dysfunction were included. The independent variable was the diagnosis of diabetes mellitus and the dependent variable was the diagnosis of corpus cavernosum arterial insufficiency. Association statistics were performed and prevalence ratios were estimated using logistic regression.
Results: Of 887 patients, the mean age was 48.5 years. In the bivariate analysis, an association was found between diabetes mellitus and corpus cavernosum arterial insufficiency (p< 0.001). In the simple regression analysis, the prevalence of having corpus cavernosum arterial insufficiency was 92% higher in patients who had diabetes mellitus (OR: 1.92; 95% CI: 1.75-2.11; p< 0,001).
Conclusions:
There is an association between diabetes mellitus and corpus cavernosum arterial insufficiency in patients with erectile dysfunction, the prevalence of corpus cavernosum arterial insufficiency was notably higher in patients with diabetes mellitus.

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References

1. Ludwig W, Phillips M. Organic causes of erectile dysfunction in men under 40. Urol Int. 2014 [acceso: 27/09/2022]; 92(1):1-6. Disponible en: https://www.karger.com/Article/Fulltext/354931#:~:text=Organic%20etiologies%20include%20vascular%2C%20neurogenic,to%20focal%20arterial%20occlusive%20disease

2. Mitidieri E, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R. Pharmacology and perspectives in erectile dysfunction in man. Pharmacol Ther. 2020 [acceso: 27/09/2022]; 208:107493. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0163725820300218

3. Rezaee ME, Ward CE, Brandes ER, Munarriz RM, Gross MS. A Review of Economic Evaluations of Erectile Dysfunction Therapies. Sex Med Rev. 2020 [acceso: 27/09/2022]; 8(3):497-503. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S2050052119300587?via%3Dihub

4. Muneer A, Kalsi J, Nazareth I, Arya M. Erectile dysfunction. BMJ. 2014 [acceso: 27/09/2022]; 348: g129. Disponible en: https://in.bgu.ac.il/en/fohs/communityhealth/Family/Documents/ERECTILE%20DYSFUNCTION%20%20%20BMJ%20%202014.pdf

5. McMahon CG. Erectile dysfunction. Intern Med J. 2014 [acceso: 27/09/2022]; 44(1):18-26. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/imj.12325

6. Schwartz BG, Kloner RA. Cardiology patient page: cardiovascular implications of erectile dysfunction. Circulation. 2011 [acceso: 27/09/2022]; 123(21):e609-11. Disponible en: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.017681

7. Taylor R. Type 2 diabetes: etiology and reversibility. Diabetes Care. 2013 [acceso: 04/10/2022]; 36(4):1047-55. Disponible en: https://diabetesjournals.org/care/article/36/4/1047/37962/Type-2-DiabetesEtiology-and-reversibility

8. Naranjo-Hernández Y. La diabetes mellitus: un reto para la Salud Pública. Rev Finlay. 2016 [acceso: 04/10/2022];6(1):[aprox. 1 p.]. Disponible en: http://scielo.sld.cu/pdf/rf/v6n1/rf01106.pdf

9. Villacorta J, Hilario N, Inolopú J, Terrel L, Labán R, Del Aguila J, et al. Factores asociados a complicaciones crónicas de diabetes mellitus tipo 2 en pacientes de un hospital general del Seguro Social de Salud del Perú. An Fac med. 2020 [acceso: 04/10/2022]; 81(3):308-15. Disponible en: http://www.scielo.org.pe/pdf/afm/v81n3/1025-5583-afm-81-03-00308.pdf

10. Thiruvoipati T, Kielhorn CE, Armstrong EJ. Peripheral artery disease in patients with diabetes: Epidemiology, mechanisms, and outcomes. World J Diabetes. 2015 [acceso: 04/10/2022]; 6(7):961-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499529/pdf/WJD-6-961.pdf

11. Thipsawat S. Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature. Diab Vasc Dis Res. 2021 [acceso: 04/10/2022]; 18(6):1-9. Disponible en: https://journals.sagepub.com/doi/pdf/10.1177/14791641211058856

12. Caretta N, De Rocco-Ponce M, Minicuci N, De Santis I, Palego P, Garolla A, et al. Efficacy of penile low-intensity shockwave treatment for erectile dysfunction: correlation with the severity of cavernous artery disease. Asian J Androl. 2021 [acceso: 27/02/2023]; 23(5):462-7. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451489/pdf/AJA-23-462.pdf

13. Figueroa-García J. Pérez-Patricia AJ. Asociación del control glucémico y disfunción eréctil en pacientes diabéticos. Rev Mex Urol. 2021 [acceso: 11/10/2022]; 77(1):5-11. Disponible en: https://www.scielo.org.mx/scielo.php?pid=S2007-40852017000100005&script=sci_arttext

14. Sandoval-Salinas C, Martínez JM, Corredor HA, Saffon JP, Jaramillo C, Mendoza F. Prevalencia y asociación de factores de riesgo cardiovascular en hombres con disfunción eréctil. Rev Colomb Cardiol. 2021 [acceso: 11/10/2022]; 27(6):5-26. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-56332020000600526

15. MacDonald SM, Burnett AL. Physiology of Erection and Pathophysiology of Erectile Dysfunction. Urol Clin North Am. 2021 [acceso: 11/10/2022]; 48(4):513-25. Disponible en: https://www.urologic.theclinics.com/article/S0094-0143(21)01859-0/pdf

16. Morgado A, Moura ML, Dinis P, Silva CM. Misdiagnosis And Undertreatment Of Erectile Dysfunction In The Portuguese Primary Health Care. Sex Med. 2019 [acceso: 11/10/2022]; 7(2):177-83. Disponible en: https://www.smoa.jsexmed.org/article/S2050-1161(19)30010-8/pdf

17. Geng Q, Chen S, Sun Y, Zhao Y, Li Z, Wang F, et al. Correlation between gut microbiota diversity and psychogenic erectile dysfunction. Transl Androl Urol. 2021 [acceso: 11/10/2022]; 10(12):4412-21. Disponible en: https://tau.amegroups.com/article/view/85551/html

18. Mulhall JP, Giraldi A, Hackett G, Hellstrom WJG, Jannini EA, Rubio-Aurioles E, et al. The 2018 Revision to the Process of Care Model for Management of Erectile Dysfunction. J Sex Med. 2018 [acceso: 11/10/2022]; 15(10):1434-45. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1743609518310506

19. Jenkins LC, Hall M, Deveci S, Guhring P, Parker M, Nelson CJ, et al. An Evaluation of a Clinical Care Pathway for the Management of Men With Nonorganic Erectile Dysfunction. J Sex Med. 2019 [acceso: 14/10/2022]; 16(10):1541-6. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1743609519313177

20. Aguilera-Lagos R, Díaz-López EJ, Colman-Juárez, Carranza-Pagoada RE, Padilla-Meza JC, Cáceres-Munguía GI. Enfermedad arterial periférica y diabetes mellitus de tipo 2 en atención primaria. Rev Cubana Angiol Cir Vasc. 2020 [acceso: 14/10/2022]; 21(2):e113. Disponible en: http://scielo.sld.cu/pdf/ang/v21n2/1682-0037-ang-21-02-e113.pdf

21. Kaya C, Uslu Z, Karaman I. Is endothelial function impaired in erectile dysfunction patients? Int J Impot Res. 2006 [acceso: 14/10/2022]; 18(1):55-60. Disponible en: https://www.nature.com/articles/3901371

22. Bertolotto M, Campo I, Sachs C, Ciabattoni R, Bucci S, Cova MA, et al. Sonography of the penis/erectile dysfunction. Abdom Radiol (NY). 2020 [acceso: 14/10/2022]; 45(7):1973-89. Disponible en: https://link.springer.com/article/10.1007/s00261-020-02529-z

23. Chantada-Abal V, Julve-Villaita E. Pruebas complementarias en el diagnóstico de la disfunción eréctil: ¿Cuáles y cuándo? Arch Esp Urol. 2010 [acceso: 14/10/2022]; 63(8):687-92. Disponible en: https://scielo.isciii.es/pdf/urol/v63n8/15.pdf

24. Gomez-Varela C, Mateos-Yeguas LA, Couto-Rodríguez I, Durán-Vila MD. Penile Doppler Ultrasound for Erectile Dysfunction: Technique and Interpretation. AJR. 2020 [acceso: 15/10/2022]; 214:1112-21. Disponible en: https://www.ajronline.org/doi/pdf/10.2214/AJR.19.22141

25. Chen L, Xu L, Wang J, Li H, Zhang D, Zhang C, et al. Diagnostic Accuracy of Different Criteria of Pharmaco-penile Duplex Sonography for Venous Erectile Dysfunction. J Med Ultrasound. 2019 [acceso: 15/10/2022]; 38(10):2739-48. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/jum.14982

26. Ma M, Yu B, Qin F, Yuan J. Current approaches to the diagnosis of vascular erectile dysfunction. Transl Androl Urol. 2020 [acceso: 15/10/2022]; 9(2):709-21. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215019/pdf/tau-09-02-709.pdf

Published

2023-05-10

How to Cite

1.
Hernández-Yépez PJ, Inga-Berrospi F, Muñoz Medina C, Velezmoro Diaz V, Grandez-Urbina JA. Association between diabetes mellitus and corpus cavernosum arterial insufficiency in patients with erectile dysfunction. Rev Cubana Med Milit [Internet]. 2023 May 10 [cited 2025 Jan. 9];52(2):e02302726. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2726

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Research Article

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