Concentration and the value of D-dimer in the diagnosis of deep vein thrombosis
Keywords:
D-dimer concentration, D-dimer diagnostic value, deep vein thrombosis.Abstract
Introduction: Quantification of D-dimer levels is a valuable test in orienting the diagnosis of deep vein thrombosis.Objectives: Determine D-dimer concentration and diagnostic value of D-dimer in patients with deep venous thrombosis.
Methods: A descriptive, uncontrolled study was performed in 260 elderly patients at risk of deep vein thrombosis. All patients underwent quantitative D-dimer assay.
Results: The D-dimer concentration of patients with deep venous thrombosis had a median of 3106.5 ng/ml and was about 1.5 times higher than that of patients without deep venous thrombosis. With a threshold of D-dimer concentration of 500 ng/mL to determine deep venous thrombosis, the specificity of the method is low (16.51%), but the sensitivity is high (100%). And the positive predictive value is low (18.75%) but the negative predictive value is absolute (100%).
Conclusion: With a threshold of D-dimer concentration of 500 ng/mL to determine deep venous thrombosis, the specificity and positive predictive value of the method are low, but the sensitivity and negative predictive value are high.
Downloads
Download data is not yet available.
References
1. Di NM, Van EN, Büller HR. Deep vein thrombosis and pulmonary embolism. The Lancet. 2016 [access: 30/06/2016]; 388(10063):3060-73. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0140673616305141
2. Hien NT, Phuong TT, Quynh PT, Thu NNP, Yen TTM. Diagnosis of deep vein thrombosis. Ho Chi Minh City: University of Medicine and Pharmacy; 2018. [access: 29/11/2018]. Available at: https://thaythuocvietnam.vn/thuvien/wp-content/uploads/2018/11/37-1.pdf
3. Phuoc DV, Tri NV. Evaluation of the role of D-Dimer in the diagnosis of deep vein thrombosis. Medical Journal of Ho Chi Minh City. 2010 [access: 22/06/2010]; 14(2):178-183. Available at: https://timmachhoc.vn/anh-gia-vai-tro-ca-d-dimer-trong-chn-oan-huyt-khi-tnh-mch-sau
4. Owaidah T, AlGhasham N, AlGhamdi S, AlKhafaji D, ALAmro B, Zeitouni M, et al. Evaluation of the usefulness of a D dimer test in combination with clinical pretest probability score in the prediction and exclusion of Venous Thromboembolism by medical residents. Thrombosis journal. 2014 [access: 16/12/2014]; 12(1):8-28. Available at: https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-014-0028-7
5. Kassim NA, Farid TM, Pessar SA, Shawkat SA. Performance Evaluation of Different d-Dimer Cutoffs in Bedridden Hospitalized Elderly Patients. Clin Appl Thromb Hemost. 2017 [access: 06/10/2017]; 23(8):998-1004. Available at: https://journals.sagepub.com/doi/full/10.1177/1076029616665165
6. Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA, et al. Prevention of venous thromboembolism. Chest. 2001 [access: 01/01/2001]; 119(Suppl 1):132s-175s. Available at: https://journal.chestnet.org/article/S0012-3692(15)60785-1/fulltext
7. Kahn SR. The Clinical Diagnosis of Deep Venous Thrombosis: Integrating Incidence, Risk Factors, and Symptoms and Signs. Archives of Internal Medicine. 1998 [access: 23/10/1998]; 158(21):2315-23. Available at: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/210568
8. Schouten HJ, Koek HL, Oudega R, Geersing GJ, Janssen KJ, van Delden JJ, et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ. 2012 [access: 22/03/2012]; 344:e2985. Available at: https://www.bmj.com/content/344/bmj.e2985.short
9. Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003 [access: 25/09/2003]; 349(13):1227-35. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa023153
10. Desjardins L, Bara L, Boutitie F, Michel SM, Cohen AT, Combe S, et al. Correlation of Plasma Coagulation Parameters with Thromboprophylaxis, Patient Characteristics, and Outcome in the MEDENOX Study. Archives of Pathology & Laboratory Medicine. 2004 [access: 01/05/2004]; 128(5):519-26. Available at: https://meridian.allenpress.com/aplm/article/128/5/519/458737/Correlation-of-Plasma-Coagulation-Parameters-With
11. Qaseem A, Snow V, Barry P, Hornbake ER, Rodnick JE, Tobolic T, et al. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med. 2007; 5(1):57-62. DOI: 10.7326/0003-4819-146-6-200703200-00013
12. Carrier M, Le Gal G, Bates SM, Anderson DR, Wells P. D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatients. J Thromb Haemost. 2008; 6(7):1072-76. DOI: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1538-7836.2008.03007.x
13. Harper PL, Theakston E, Ahmed J, Ockelford P. D‐dimer concentration increases with age reducing the clinical value of the D‐dimer assay in the elderly. Internal medicine journal. 2007; 37(9):607-13. DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1445-5994.2007.01388.x
14. Prochaska JH, Frank B, Nagler M, Lamparter H, Weißer G, Schulz A, et al. Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Sci Rep. 2017 [access: 04/07/2007]; 7(1):4591. Available at: https://www.nature.com/articles/s41598-017-04843-x
2. Hien NT, Phuong TT, Quynh PT, Thu NNP, Yen TTM. Diagnosis of deep vein thrombosis. Ho Chi Minh City: University of Medicine and Pharmacy; 2018. [access: 29/11/2018]. Available at: https://thaythuocvietnam.vn/thuvien/wp-content/uploads/2018/11/37-1.pdf
3. Phuoc DV, Tri NV. Evaluation of the role of D-Dimer in the diagnosis of deep vein thrombosis. Medical Journal of Ho Chi Minh City. 2010 [access: 22/06/2010]; 14(2):178-183. Available at: https://timmachhoc.vn/anh-gia-vai-tro-ca-d-dimer-trong-chn-oan-huyt-khi-tnh-mch-sau
4. Owaidah T, AlGhasham N, AlGhamdi S, AlKhafaji D, ALAmro B, Zeitouni M, et al. Evaluation of the usefulness of a D dimer test in combination with clinical pretest probability score in the prediction and exclusion of Venous Thromboembolism by medical residents. Thrombosis journal. 2014 [access: 16/12/2014]; 12(1):8-28. Available at: https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-014-0028-7
5. Kassim NA, Farid TM, Pessar SA, Shawkat SA. Performance Evaluation of Different d-Dimer Cutoffs in Bedridden Hospitalized Elderly Patients. Clin Appl Thromb Hemost. 2017 [access: 06/10/2017]; 23(8):998-1004. Available at: https://journals.sagepub.com/doi/full/10.1177/1076029616665165
6. Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA, et al. Prevention of venous thromboembolism. Chest. 2001 [access: 01/01/2001]; 119(Suppl 1):132s-175s. Available at: https://journal.chestnet.org/article/S0012-3692(15)60785-1/fulltext
7. Kahn SR. The Clinical Diagnosis of Deep Venous Thrombosis: Integrating Incidence, Risk Factors, and Symptoms and Signs. Archives of Internal Medicine. 1998 [access: 23/10/1998]; 158(21):2315-23. Available at: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/210568
8. Schouten HJ, Koek HL, Oudega R, Geersing GJ, Janssen KJ, van Delden JJ, et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis. BMJ. 2012 [access: 22/03/2012]; 344:e2985. Available at: https://www.bmj.com/content/344/bmj.e2985.short
9. Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003 [access: 25/09/2003]; 349(13):1227-35. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa023153
10. Desjardins L, Bara L, Boutitie F, Michel SM, Cohen AT, Combe S, et al. Correlation of Plasma Coagulation Parameters with Thromboprophylaxis, Patient Characteristics, and Outcome in the MEDENOX Study. Archives of Pathology & Laboratory Medicine. 2004 [access: 01/05/2004]; 128(5):519-26. Available at: https://meridian.allenpress.com/aplm/article/128/5/519/458737/Correlation-of-Plasma-Coagulation-Parameters-With
11. Qaseem A, Snow V, Barry P, Hornbake ER, Rodnick JE, Tobolic T, et al. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med. 2007; 5(1):57-62. DOI: 10.7326/0003-4819-146-6-200703200-00013
12. Carrier M, Le Gal G, Bates SM, Anderson DR, Wells P. D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatients. J Thromb Haemost. 2008; 6(7):1072-76. DOI: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1538-7836.2008.03007.x
13. Harper PL, Theakston E, Ahmed J, Ockelford P. D‐dimer concentration increases with age reducing the clinical value of the D‐dimer assay in the elderly. Internal medicine journal. 2007; 37(9):607-13. DOI: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1445-5994.2007.01388.x
14. Prochaska JH, Frank B, Nagler M, Lamparter H, Weißer G, Schulz A, et al. Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Sci Rep. 2017 [access: 04/07/2007]; 7(1):4591. Available at: https://www.nature.com/articles/s41598-017-04843-x
Published
2023-05-11
How to Cite
1.
Phan VN-T, Nguyen DN, Bui TD-M, Tong MD, Nguyen TH, Nguyen DT-N. Concentration and the value of D-dimer in the diagnosis of deep vein thrombosis. Rev Cubana Med Milit [Internet]. 2023 May 11 [cited 2025 Jan. 8];52(2):e02302728. Available from: https://revmedmilitar.sld.cu/index.php/mil/article/view/2728
Issue
Section
Research Article
License
Authors who have publications with this Journal accept the following terms:
- The authors will retain their copyright and guarantee the Journal the right of first publication of their work, which will simultaneously be subject to the Creative Commons Attribution License. The content presented here can be shared, copied and redistributed in any medium or format; Can be adapted, remixed, transformed or created from the material, using the following terms: Attribution (giving appropriate credit to the work, providing a link to the license, and indicating if changes have been made); non-commercial (you cannot use the material for commercial purposes) and share-alike (if you remix, transform or create new material from this work, you can distribute your contribution as long as you use the same license as the original work).
- The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (for example: depositing it in an institutional electronic archive or publishing it in a monographic volume) as long as the initial publication in this Journal is indicated.
- Authors are allowed and recommended to disseminate their work through the Internet (e.g., in institutional electronic archives or on their website) before and during the submission process, which can produce interesting exchanges and increase citations. of the published work.
