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Concentración de cadenas ligeras libres en el suero y relación con algunas caracterÃsticas de pacientes con mieloma múltiple
Resumen
Objetivo: Determinar las caracterÃsticas de la concentración de cadenas ligeras libres en el suero y su relación con algunas caracterÃsticas clÃnicas y subclÃnicas en pacientes con mieloma múltiple.
Métodos: Se realizó un estudio descriptivo, retrospectivo, no controlado, en 74 pacientes con mieloma múltiple. Todos los pacientes completaron pruebas cuantitativas de cadena ligera libre en el suero κ y cadena ligera libre en suero λ.
Resultados: El mieloma múltiple de inmunoglobulina intacta representó a la mayorÃa de los pacientes (81 %). La mayorÃa de los pacientes tenÃan cadenas ligeras libres séricas anormales en el momento del diagnóstico (98,6 %). La concentración elevada de cadenas ligeras libres en el suero correlacionó con concentración de proteÃna M > 3 g/dL (p< 0,05) y no hubo correlación estadÃsticamente significativa entre cadenas ligeras libres en el suero elevadas y otras caracterÃsticas clÃnicas y subclÃnicas.
Conclusión: La mayorÃa de los pacientes con mieloma múltiple tienen cadenas ligeras libres séricas elevadas en el momento del ingreso. Se observa correlación de cadenas ligeras libres séricas altas, con la proteÃna M sérica aumentada.
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Referencias
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